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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE306433 The IL-10/IL-10Ra axis in fibroblasts limits large intestinal pathology by suppressing type I interferon signaling [RNA-Seq] May 17, 2026Contributors : Takayoshi Ito ; Daisuke Motooka ; Hisako KayamaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the intestines, stromal cells are essential for epithelial homeostasis, supplying both stem cell niche signals and differentiation factors. Recent studies have shown that they play crucial roles not only in e […]
- GSE306432 The IL-10/IL-10Ra axis in fibroblasts limits large intestinal pathology by suppressing type I interferon signaling [scRNA-Seq] May 17, 2026Contributors : Bo Li ; Daisuke Okuzaki ; Hisako KayamaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the intestines, stromal cells are essential for epithelial homeostasis, supplying both stem cell niche signals and differentiation factors. Recent studies have shown that they play crucial roles not only in epithelia […]
- GSE306443 The IL-10/IL-10Ra axis in fibroblasts limits large intestinal pathology by suppressing type I interferon signaling [RNA-Seq, part2] May 17, 2026Contributors : Bo Li ; Daisuke Motooka ; Hisako KayamaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the intestines, stromal cells are essential for epithelial homeostasis, supplying both stem cell niche signals and differentiation factors. Recent studies have shown that they play crucial roles not only in epithelia […]
- GSE306442 The IL-10/IL-10Ra axis in fibroblasts limits large intestinal pathology by suppressing type I interferon signaling [scRNA-Seq, part2] May 17, 2026Contributors : Takayoshi Ito ; Daisuke Okuzaki ; Hisako KayamaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the intestines, stromal cells are essential for epithelial homeostasis, supplying both stem cell niche signals and differentiation factors. Recent studies have shown that they play crucial roles not only in e […]
- GSE260675 Next Generation Sequencing Facilitates Quantitative Analysis of WT and edf1 mutant Transcriptomes in W22 Background May 17, 2026Contributors : Hongtao Liu ; Zhiwei Zhao ; Huafeng Liang ; Jianbing Yan ; Chengxiu WuSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysAnalysis of all gene expression in WT and edf1 in W22 background.The hypothesis tested in the present study was genes were regulated by EDF1.
- GSE330859 Differential recognition of C. neoformans by male and female human macrophages elicits contrasting immune responses May 17, 2026Contributor : Erin E McClellandSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformans ; Homo sapiensCryptococcus neoformans (Cn) is a pathogenic yeast and the cause of cryptococcosis, a life-threatening fungal disease. Strikingly, ~70% of patients that develop cryptococcosis are male. Here, we investigated decrease […]
- GSE329993 IRF1 rs2057656 Polymorphism Regulates IRF1-AS1 Transcription and Immune Dysfunction in ARDS via Allele-Specific Epigenetic Repression [ChIP-seq] May 17, 2026Contributors : Shi Zhang ; Yuanyuan ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAcute respiratory distress syndrome (ARDS) is a severe and life-threatening variant of respiratory failure. Effective targeted therapies are lacking, and patient heterogeneity is substantial. Interferon regulat […]
- GSE297199 The landscape of gain and loss of function mutations in melanoma [RNA-seq] May 17, 2026Contributors : Noam Auslander ; Meenhard Herlyn ; Jayamanna Wickramasinghe ; Bryant Duong ; Konstantinos TsingasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMelanoma is a common and aggressive cancer, with a rising incidence in most developed countries. Major discoveries in melanoma biology have been rapidly translat […]
- GSE330687 PD-L1 drives metabolic reprogramming and mitochondrial remodeling in NSCLC cells May 17, 2026Contributors : Xiangjun Shi ; Chenglong Liu ; Siqi Mou ; Junsheng Li ; Peicong Ge ; Xuebin LiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor metabolism is governed by a complex network of processes that can influence immune evasion. Metabolic dysregulation in tumor cells often result in the accumulation of bypro […]
- GSE330529 Transcriptomic Profiling Identifies GPNMB as a Key Driver of Gastric Cancer Aggressiveness May 17, 2026Contributors : Long Cheng ; Daiyuan MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe aimed to define the role of GPNMB in gastric cancer (GC) progression and its underlying mechanisms. Stable GPNMB-knockdown/overexpression GC cell models were established, and transcriptomic profiling identified the cAMP signaling pa […]
- GSE330741 In Vivo Massively Parallel Reporter Assay Reveals Sequence Determinants of mRNA Localization in Astrocytes May 17, 2026Contributors : Sarah K Koester ; Kristina Sakers ; Gareth M Rurak ; Stephen P Plassmeyer ; Kelli McFarland White ; Sebastian Alves Ferreira Dias ; Peter Baird ; Dina J Kornbluth ; Joseph D DoughertySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSubcellular mRNA localization and local translation are essential mechanism […]
- GSE330761 CD25 expression marks an activated mast cell population in human nasal polyposis May 17, 2026Contributors : Daniel F Dwyer ; Rizza U SantosSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground- Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a Th2 disease characterized by heterogeneous mast cell hyperplasia. We previously used transcriptomics to identify discrete gene expression linked with intr […]
- GSE330780 Dissection of innate-immune-ligand- and interferon-protein-mediated transcriptional responses in human THP1 cell states May 17, 2026Contributors : Lama Lodoe ; Morozov PavelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInterferon regulatory factors (IRFs) are essential for transcription of interferons (IFNs), interferon-stimulated genes (ISGs), and pro-inflammatory cytokines. We profile the transcriptome of human monocyte THP1 cells challenged wit […]
- GSE298502 The landscape of gain and loss of function mutations in melanoma May 17, 2026Contributors : Noam Auslander ; Meenhard Herlyn ; Jayamanna Wickramasinghe ; Bryant Duong ; Konstantinos TsingasSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensMelanoma is a common and aggressive cancer, with a rising incidence in most developed countries. Major discoveries in melanoma biology have been rapidly translated, allowing cur […]
- GSE328092 Next Generation Sequencing Facilitates Quantitative Analysis of WT and apl mutant Transcriptomes in Zheng58 Background May 17, 2026Contributors : Hongtao Liu ; Zhiwei Zhao ; Huafeng Liang ; Jianbing Yan ; Chengxiu WuSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysAnalysis of all gene expression in WT and apl in Zheng58 background.The hypothesis tested in the present study was genes were regulated by APL.