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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE280266 Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory circuits During Response to MAPK Inhibition in BRAF-mutant colorectal cancer. April 24, 2026Contributors : Hey Min Lee ; Kunal Rai ; Scott KopetzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Aberrant enhancer dynamics play a critical role in the initiation and progression of colorectal cancer (CRC). BRAFV600E-mutated metastatic CRC may be a unique subtype, exhibiting a strong epigenetic phenotype […]
- GSE272586 Transcription factor binding in early pancreatic progenitors (PP1) April 24, 2026Contributors : Xian Zhang ; Dapeng Yang ; Wilfred Wong ; Christina Leslie ; Danwei HuangfuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe established a human pluripotent stem cell (hPSC)-derived pancreatic progenitor organoid (PO) culture that provides the cellular plasticity for PDAC modeling and suppo […]
- GSE295555 Numb-Ifi204 inhibits microglial activation and the hippocampal inflammation induced by LPS. April 24, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aimed to identify the mechanisms regulating microglial activation and to explore potential therapeutic targets for neuroinflammation-related cognitive dysfunction disorders. We uncover a novel role for Numb in regulating microglial activation and highlight its i […]
- GSE289312 Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium April 24, 2026Contributors : Elise Bornet ; Gianluca Prezza ; Laura Cecchino ; Laura Jenniches ; Jochen Behrends ; Caroline Tawk ; Kerwyn Casey Huang ; Till Strowig ; Jorg Vogel ; Lars Barquist ; Antoine-Emmanuel Saliba ; Alexander J WestermannSeries Type : Expression profiling by high throughput sequencingOrganism : Bacteroides thetaiotaomicronIsogenic bacteria can be ph […]
- GSE296424 Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer [Hi-C] April 24, 2026Contributors : Liliana Garcia-Martinez ; Mengsheng Zha ; Rodrigo L Borges ; Tong Liu ; Gretter González-Blanco ; Hao Zhu ; Zheng Wang ; Lluis MoreySeries Type : OtherOrganism : Homo sapiensChromatin architecture plays a key role in development and cancer, yet most studies lack mechanistic depth due to widespread epigenomic remodeling. To address this, we tra […]
- GSE296037 Fragile nucleosomes are coupled with transcription activation of RNA Polymerase II [RNA-seq] April 24, 2026Contributors : Li Lingbo ; Hunter Samuel ; Leach Sonia ; Zhuang Yonghua ; Liu Haolin ; Gao Junfeng ; Zhang Qianqian ; Stasevich Timothy ; Kimura Hiroshi ; Dowell Robin ; Zhang GongyiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eu […]
- GSE328517 Compare the differences in gene expression of TAMs in mouse tumor tissues treated with AdV-Fe3O4@PACM and AdV-iCD47-Fe3O4@PACM. April 24, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOncolytic adenoviruses (AdVs) represent a promising immunotherapeutic approach against cancer, yet their clinical translation is hindered by rapid systemic clearance, poor tumor accumulation, limited extravasation across the endothelial barrier, and an immunosuppressive tu […]
- GSE308184 Stress granule phase separation in stress-responsive cytosolic extract-in-oil droplets April 24, 2026Contributors : Aline Reuter ; Nathan Mikhaylenko ; Oskar Staufer ; Alessia RuggieriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensStress granules (SGs) are biomolecular condensates that form transiently in the cytosol of mammalian cells in response to stress. Dysregulation of their assembly or disassembly is implicated […]
- GSE328593 Multiomic studies of a murine model of human mixed phenotype acute leukemia April 24, 2026Contributors : Alessia Bortoluzzi ; Chunxiao Zhang ; Hyejin Cho ; Arthur Li ; Xiwei Wu ; Jinhui Wang ; WenYong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMixed phenotype acute leukemia (MPAL) is a rare and highly aggressive leukemia with poorly understood pathobiology. We previously developed a spontaneous mous […]
- GSE328550 Macrophage-fibroblast crosstalk shapes wound repair signaling in vitro April 24, 2026Contributors : Wendy F Liu ; Maksim V Plikus ; Daniela Enriquez-Ochoa ; Raji R Nagalla ; Yingzi Liu ; Christian F Guerrero-JuarezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWound healing requires coordinated interactions between macrophages and fibroblasts, yet how contact-dependent signaling integrates with paracri […]
- GSE328657 circRNA_013145–miR-185-5p–RhoA Axis: A Novel Mechanism in the Pathophysiology of Diabetes-induced Erectile Dysfunction April 24, 2026Contributors : Wenhan Huang ; Jianxiong MaSeries Type : Non-coding RNA profiling by arrayOrganism : Rattus norvegicusThis study investigated circRNA expression profiles in penile tissues of DMED rats using high-throughput microarray
- GSE328669 A spatial in situ hybridization platform for T cell receptor variable gene-based clonotype analysis in tissue April 24, 2026Contributors : Cedric Ly ; Darius P Schaub ; Robin Khatri ; Zeba Sultana ; Annika Boxnick ; Zheng Song ; Tobias Huber ; Thorsten Wiech ; Eva Tolosa ; Ulf Panze ; Stefan Bonn ; Christian Krebs ; Immo PrinzSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensResolving T cell clonality at single-cell spatial resolution […]
- GSE328711 Multiomic studies of a murine model of human mixed phenotype acute leukemia [RRBS] April 24, 2026Contributors : Alessia Bortoluzzi ; Chunxiao Zhang ; Hyejin Cho ; Arthur Li ; Xiwei Wu ; Jinhui Wang ; WenYong ChenSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusMixed phenotype acute leukemia (MPAL) is a rare and highly aggressive leukemia with poorly understood pathobiology. We previously developed a spontaneous mou […]
- GSE272460 Transcriptome analysis of pancreatic progenitor organoids (POs) carrying PDAC related mutations, treated with ERK inhibitors and depleted of AP-1 factors April 24, 2026Contributors : Xian Zhang ; Wilfred Wong ; Christina Leslie ; Danwei HuangfuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe established a human pluripotent stem cell (hPSC)-derived pancreatic progenitor organoid (PO) culture that provides the cellular plasticity for PDAC modeling and supports robust gene editing. Thr […]
- GSE328514 Chronic Reduction of Topoisomerase IIβ Alters Neural Circuit Function and Behavior in Mice April 24, 2026Contributors : Xianghe Song ; Tomohiro Iguchi ; Soichiro Ide ; Shintaro Yamada ; Ngo Thi To Trinh ; Yumiko Hatanaka ; Midori Yamaguchi ; Hiroshi Shitara ; Masato T Kanemaki ; Hideya Kawaji ; Kimiko Fukuda ; Chiaki Ohtaka-Maruyama ; Hiroyuki SasanumaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe purpose of this stud […]