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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE309822 Filamin–ETV4/5 acts as mechanosensor–mechanotransducer axis that drives cell competition-mediated elimination of transformed cells April 20, 2026Contributors : Jiaying Wen ; Kazuhito Sai ; Suzuka Masutani ; Yuki Aoshima ; Kotaro Yumi ; Tomoki Kyo ; Junya Hasegawa ; Toshiki Itoh ; Ken Mizuta ; Tomonori Nakamura ; Yukihiro Yabuta ; Mitinori Saitou ; Satoshi Toda ; Yasuyuki FujitaSeries Type : Expression profiling by high throughput sequencingOrganism : Cell competition is a fundamental surveillance mec […]
- GSE307028 DNA-PK Mediated CRTC2 Phosphorylation Promotes CRTC2 Relocation from Transcription to Repair Complexes Enhancing NHEJ and Suppressing Abscopal Effect April 20, 2026Contributor : Fangdi ZouSeries Type : Expression profiling by high throughput sequencingOrganism : DNA damage repair and transcription are antagonistic cellular processes that require precise spatiotemporal coordination to maintain genomic integrity. Transcriptional silencing at DSB sites is essential for efficient repair, mediated through localized histone […]
- GSE275308 Single cell RNA sequencing (scRNA-seq) of embryonic zebrafish and human aortic endothelial cells following flow modulation April 20, 2026Contributors : Aryan Kaveh ; Antonio G Salazar-Martin ; Wei Dai ; Aaron P Kithcart ; Emily Pan ; Ashmita KC ; Tyler R Reinoso ; Franki Vetrano-Olsen ; Kusumika Saha ; Manu Beerens ; Peter Libby ; Elazer R Edelman ; Calum A MacRaeSeries Type : Expression profiling by high throughput sequencingOrganism : The earliest vascular manifestations during atherosclero […]
- GSE328484 LASER couples damage sensing to ESCRT assembly for lysosome repair April 20, 2026Contributors : Claire Goul ; Aakriti Jain ; Samira Yitiz ; Elly Z Soltani ; Serim Yang ; Simon Rapp ; Martina Spacci ; Scot Federman ; James Sacco ; Huinan Li ; Lauren D Enriquez ; Nalan Liv ; Laralynne Przybyla ; Roberto ZoncuSeries Type : OtherOrganism : Lysosomal membrane integrity is essential for cell survival, but how damage sensing is spatiotemporally […]
- GSE288427 Translational changes upon aging and dietary restriction in progeroid DNA-repair-deficient mice April 20, 2026Contributors : Ivar van Galen ; Rutger A Ozinga ; Sebastiaan van Heesch ; Jan H Hoeijmakers ; Wilbert P VermeijSeries Type : Expression profiling by high throughput sequencingOrganism : Aging is a complex multifactorial phenomenon largely driven by damaged macromolecules. We showed recently that with aging time- and exposure-dependent accumulation of DNA dam […]
- GSE279841 Transcripts identified by microarray analysis that were deregulated in E15.5 Pax2-cre/+;Trp63(dN-flox/dN-flox) (ΔNp63-cKO) ureters April 20, 2026Contributors : Andreas Kispert ; Fairouz QasrawiSeries Type : Expression profiling by arrayOrganism : Evaluation of the transcriptional changes in E15.5 ureters upon loss of ΔNp63 in the ureteric epithelium.
- GSE327675 Using Chip-seq to analyze the distribution of XRCC5/6 on HBV DNA April 20, 2026Contributors : Jiangpeng Feng ; Wuxiang GuanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : In this study, we found that XRCC5/6, as DNA-binding proteins, can bind to HBV DNA and regulate HBV transcription. To directly analyze the binding regions of XRCC5/6 on HBV DNA, ChIP-seq was performed in HepG2.2.15 cells using […]
- GSE294511 Gene expression profiling of tumor organoids of colorectal liver metastases. April 20, 2026Contributors : Anita Sveen ; Kushtrim Kryeziu ; Ragnhild A LotheSeries Type : Expression profiling by arrayOrganism : We have performed gene expression profiling of patient-derived tumor organoids (PDOs) and tissue samples of resected liver metastases from patients with metastatic colorectal cancer.
- GSE328112 RNA-seq profiling of non-muscle invasive bladder cancer (NMIBC) tumors April 20, 2026Contributors : Robert T Lawrence ; Joseph D DekkerSeries Type : Expression profiling by high throughput sequencingOrganism : Bulk RNA-seq was performed on fresh-frozen non-muscle invasive bladder cancer (NMIBC) tumor biopsies obtained from commercial biobanks (BioIVT and Proteogenex). These data were generated to characterize the transcriptomic landscape of […]
- GSE327677 Using iCLIP-seq to analyze the distribution of XRCC5/6 on HBV RNA April 20, 2026Contributors : Jiangpeng Feng ; Wuxiang GuanSeries Type : OtherOrganism : In this study, we found that XRCC5/6, as pseudourindine reader proteins, can bind Ψ on HBV RNA and regulate HBV expresion. To directly analyze the binding sites of XRCC5/6 on HBV RNA, iCLIP-seq was performed in HepG2.2.15 cells using antibodies against XRCC5 and XRCC6, PUS1. The result […]
- GSE328169 CRISP enables comparisons of image-based spatial transcriptomic segmentation quality across ten organs April 20, 2026Contributors : Rose James Richard ; Vanover Daryll ; Santangelo PhilipSeries Type : OtherOrganism : This dataset comprises 10x Xenium image-based spatial transcriptomics data from a mouse tissue microarray (TMA) containing ten organs (brain, female reproductive tract, heart, kidney, large intestine, liver, lung, small intestine, spleen, and stomach) collecte […]
- GSE328250 scRNA-seq of cardiac neural crest cells following left atrial ligation April 20, 2026Contributors : Stephanie E Lindsey ; Robert Porter ; Aining FanSeries Type : Expression profiling by high throughput sequencingOrganism : We have employed a single cell sequencing approach using 10x Genomics scRNAseq to study the affect of altered hemodynamic patterning on cardac neural crest cells (CNCCs). CNCCs play an important role in tunica media format […]
- GSE328464 Targeting CCR1-Mediated Macrophage Phenotypic Switching to Alleviate Bladder Pain and Urinary Dysfunction in Interstitial Cystitis April 20, 2026Contributors : Ruixiang Luo ; Wenshuang Li ; Bolong Liu ; Junlong Huang ; Honglu Ding ; Chi Zhang ; Xiaoyang Li ; Ziqiao Wang ; Zheng Liu ; Xiangfu Zhou ; Jialiang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory condition with limited treatments. Alt […]
- GSE306488 DNA-PK Mediated CRTC2 Phosphorylation Promotes CRTC2 Relocation from Transcription to Repair Complexes Enhancing NHEJ and Suppressing Abscopal Effect [CUT&Tag] April 20, 2026Contributor : Fangdi ZouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : DNA damage repair and transcription are antagonistic cellular processes that require precise spatiotemporal coordination to maintain genomic integrity. Transcriptional silencing at DSB sites is essential for efficient repair, mediated through loca […]
- GSE327651 An SPFH Protein Couples Membrane Stress to Differentiation in Bacillus subtilis April 20, 2026Contributors : Sarah S Baur ; Urška Repnik ; Tobias Busche ; Louisa Rau ; Alisa Mondry ; Marc BramkampSeries Type : Expression profiling by high throughput sequencingOrganism : Bacillus subtilis adapts to fluctuating environmental stress, such as membrane perturbation or alkaline conditions, using membrane-associated regulatory complexes. Here, we rename the […]