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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE305827 Cystine import and oxidative catabolism fuel nutrient-responsive histone acetylation to unlock chromatin at endothelial cell loci and ensure vascular growth and repair [HUVEC_Ribo_ext553] April 16, 2026Contributor : Sofia-Iris BibliSeries Type : OtherOrganism : Homo sapiensEndothelial metabolic reprogramming is essential for vascular growth and critical for organ (re)generation, health and life span. Here, we identify a nuclear oxidative catabolic pathway that links cystine metabolism to endothelial gene regulation and angiogenesis. Endothelial cells prepa […]
- GSE305824 Cystine import and oxidative catabolism fuel nutrient-responsive histone acetylation to unlock chromatin at endothelial cell loci and ensure vascular growth and repair [MLEC_WT_CSE-KO_ACT] April 16, 2026Contributor : Sofia-Iris BibliSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEndothelial metabolic reprogramming is essential for vascular growth and critical for organ (re)generation, health and life span. Here, we identify a nuclear oxidative catabolic pathway that links cystine metabolism to endothelia […]
- GSE270548 Perception of a quorum sensing signal by cell surface immune receptors increases plant disease resistance April 16, 2026Contributors : Danxia He ; Yang Zhou ; Wenjia Yu ; Huiming ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosaBacterial quorum sensing (QS) during pathogenesis is an indicator of increasing danger. How sessile plants perceive QS for defense is unclear. Here, we show that Arabidopsis thaliana perceives 2
- GSE172276 Ovarian transcriptomic profiling of fitness-related genes in F4 inbred mice and to validate differentially expressed genes using qRT-PCR April 16, 2026Contributors : Pushpendra Kumar ; Amit Kumar ; B L SainiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: To investigate the differentially expressed genes in high litter size samples v/s low litter size samples of F4 inbred Swiss albino mice using RNA-Seq and to validate some identified differentially expressed […]
- GSE294356 Dual function of DOT1L suppresses tumor intrinsic immunogenicity in Hepatocellular carcinoma [ChIP-seq] April 16, 2026Contributors : Siyuan Xu ; Xianjiang LanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCheckpoint inhibitor therapy for Hepatocellular carcinoma (HCC) remains limited in patients’ overall response rate. Discovery and development of more effective combinatorial approaches in HCC checkpoint immunotherapy is […]
- GSE292550 ov_IRF9 vs WT April 16, 2026Contributor : Yin yuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNOT PROVIDED; REQUESTED
- GSE327773 Soy Isoflavone Improves Reproductive Performance and Antioxidant Capacity of Sows and Reshapes Colostrum-Derived Exosomal microRNA Profiles April 16, 2026Contributors : Qiming Duan ; Jun HeSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Sus scrofaBackground: This study investigated the effects of dietary soy isoflavone supplementation on reproductive performance, antioxidant capacity, and colostrum-derived exosomal microRNA profiles in sows, with the aim of exploring the molecul […]
- GSE302322 Neurotranscriptomics of mutualistic cleaning in Ladridae wrasses April 16, 2026Contributors : Hans A Hofmann ; Redouan Bshary ; Chelsea A Weitekamp ; Zegni Triki ; Yiheng Su ; Abigail G Beman ; Matthew A PetershackSeries Type : Expression profiling by high throughput sequencingOrganism : Coris batuensis ; Halichoeres melanurus ; Hemigymnus melapterus ; Labrichthys unilineatus ; Thalassoma lunareDespite the astonishing diversity of life […]
- GSE327797 Prolonged duration induces divergent transcriptomic responses to manganese, distinct from concentration effects, in an SH-SY5Y neurotoxicity model April 16, 2026Contributors : Xueqi Tang ; Priyanka Baloni ; Michael Aschner ; Aaron B BowmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUnderstanding manganese (Mn) neurotoxicity requires experimental models that realistically reflect human exposure scenarios. A key limitation of current in vitro paradigms is the reliance on acut […]
- GSE327779 miR-151-5p Regulates Neural Stem Cell Fate by Targeting Aph1a to Modulate Notch Signaling Gradients April 16, 2026Contributor : Xinrun WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the role of miR-151-5p in regulating neural stem cell (NSC) fate during neocortical development, we performed RNA-seq profiling of NSCs isolated from the developing mouse cerebral cortex. Conditional knockout of miR-151-5p led to inc […]
- GSE328076 LHX2 drives neuroendocrine transformation in TP53/RB1-deficient prostate cancer April 16, 2026Contributors : Shouyi Zhang ; Yu Zeng ; Guangyi Shan ; Chang Liu ; Yuyan ZhuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNeuroendocrine prostate cancer (NEPC) is an aggressive subtype that progresses after androgen deprivation therapy (ADT) resistance and has extremely poor prognosis. Its underlying reg […]
- GSE328077 Cultured ex vivo human brain tissue maintains cell-type transcriptional identities April 16, 2026Contributors : J P McGinnis ; Sai Mallannagari ; Daniel Curry ; Benjamin R ArenkielSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThere is growing recognition of the need for human-based models of the nervous system and its diseases. We used single-nucleus RNA sequencing of six patient samples to determine how well var […]
- GSE328176 Single-Cell RNA Sequencing Reveals Yiqi Huayu Jiedu Formula Alleviates Acute Respiratory Distress Syndrome Through Regulation of Macrophage Chemotaxis April 16, 2026Contributor : Boyue WangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusIntegrated network pharmacology, single-cell RNA sequencing, and experimental analyses revealed that Yiqi Huayu Jiedu Formula (YQHYJDF) protects lung tissue by inhibiting macrophage chemotaxis and neutrophil recruitment through suppression of p […]
- GSE305822 Cystine import and oxidative catabolism fuel nutrient-responsive histone acetylation to unlock chromatin at endothelial cell loci and ensure vascular growth and repair [MLEC_WT_CSE-KO_ATAC_ext251] April 16, 2026Contributor : Sofia-Iris BibliSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEndothelial metabolic reprogramming is essential for vascular growth and critical for organ (re)generation, health and life span. Here, we identify a nuclear oxidative catabolic pathway that links cystine metabolism to endothelia […]
- GSE327761 mRNA sequencing analysis of diquat herbicide-exposed (1/5 LC50) Aedes albopictus mosquito larvae at 72hours April 16, 2026Contributor : Anusruthi RamakrishnanSeries Type : Expression profiling by high throughput sequencingOrganism : Aedes albopictusDiquat, a bipyridinium aquatic herbicide, targets freshwater weeds but may also affect non-target species, such as the mosquito Aedes albopictus, in shared habitats. These results provide the first molecular insights into the effects […]