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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE275827 Deletion of immune regulatory factor Fgl2 affects the mouse spleen immune profile April 8, 2026Contributors : Jiang Chang ; Jingzhi YangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusTranscription profiles identified 18 cell types, including 9 B cell subsets, 5 T cell subsets, pc cells, monocytes, natural killer (NK) cells, and dc cells. Compared with WT group, the proportion of naive B cells, transition […]
- GSE291449 TCR Signaling Induced Kdm6b Antagonizes Ezh2 to Sustain Tissue Regulatory T Cells April 8, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE288405 Metabolic reprogramming driven by impaired trophoblasts and decidual XCR1+PMN-MDSCs crosstalk controls adverse outcomes in advanced maternal age [CUT&Tag] April 8, 2026Contributors : Meiqi Chen ; Yuxiong Guo ; Jingping Liu ; Shuyi Kuang ; Qing Zhao ; Zhengcong Huang ; Chenlin Lv ; Shuxiu Xu ; Zekai Zhuang ; Jing Li ; Yumei HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDecidual polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are crucial for maternal–fet […]
- GSE298617 Multiplex organoid mutagenesis reveals gene combinations driving transformation, pathology and chemosensitivity in ovarian carcinoma April 8, 2026Contributors : Daryl J Phuong ; Coulter R Ralston ; Alexander Y Nikitin ; John C SchimentiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHigh-grade serous ovarian carcinoma (HGSC) is the sixth leading cause of cancer-related death among women. Many cases arise from the Fallopian tubal epithelium (TE), exhibit numerous […]
- GSE295407 Polycomb Chromatin Topology Enables Long-Range Enhancer Recruitment during Craniofacial Development [Hi-C] April 8, 2026Contributors : Yousra Ben Zouari ; Onkar Joshi ; Adwait Salvi ; Sandra Kessler ; Sebastien Ducret ; Fiona Ross ; Sojoerd J Holwerda ; Nathalie Vilain ; Soujanya Mamilla-Sanivaram ; Sebastien Smallwood ; Hubertus Kohler ; Michael B Stadler ; Maryline Minoux ; Filippo M RijliSeries Type : OtherOrganism : Mus musculusLittle is known about how three-dimensional […]
- GSE307596 NAT10-Dependent N4-acetylcytidine (ac4C) on R-loops Drive Glioblastoma Tumorigenesis and Stemness [ac4C-RIP-seq] April 8, 2026Contributors : Xujia Wu ; Donghai Wang ; Jeremy RichSeries Type : OtherOrganism : Homo sapiensR-loop remodelling dynamically regulates chromatin states and gene expression; however, its exploitation by cancer stem cells to sustain self-renewal and malignancy remains poorly understood. In this study, we found that glioblastoma stem cells (GSCs) maintain a hig […]
- GSE303974 Global Gene Expression profiling of Whole Blood RNA of Type 2 Diabetes (T2D) and Azlzheimr's Disease (AD) Patient April 8, 2026Contributors : Tanmoy Mondal ; Somiranjan GhoshSeries Type : Expression profiling by arrayOrganism : Homo sapiensType 2 diabetes mellitus (T2D) and Alzheimer’s disease (AD) are a growing concern in low- and middle-income countries, including Pakistan. The relationship between T2DM and AD is complex and concerning, as more older adults with T2DM are experienc […]
- GSE327124 Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells [CRISPR KO] April 8, 2026Contributors : Pascal Devant ; Hyuncheol Jung ; Alexander Marson ; Julia CarnevaleSeries Type : OtherOrganism : Homo sapiensPrimary human myeloid cells are promising candidates for immunotherapy, yet efficient and scalable technologies for genetic engineering and screening in these cells are limited. Here we present a virus-like particle (VLP)-based toolkit […]
- GSE327102 Transcriptomic profiling of peripheral blood from myasthenia gravis patients before and after efgartigimod treatment April 8, 2026Contributors : Lei Jin ; Sushan LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeonatal Fc receptor (FcRn) blockade with efgartigimod is an effective therapy for myasthenia gravis (MG), yet the molecular changes beyond IgG clearance remain incompletely understood. In this study, paired peripheral blood samples colle […]
- GSE327347 Targeted spatial transcriptomic profiling of pleural mesothelioma using 10x Genomics Xenium April 8, 2026Contributors : David T Severson ; Sam Freyaldenhoven ; Ben Wadowski ; William G Richards ; Raphael Bueno ; Matthew B CougarSeries Type : OtherOrganism : Homo sapiensTargeted spatial transcriptomic profiling was performed on seven formalin-fixed paraffin-embedded pleural mesothelioma tumor samples from four cases using the 10x Genomics Xenium platform. The Xe […]
- GSE327133 Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells [CRISPRoff] April 8, 2026Contributors : Pascal Devant ; Hyuncheol Jung ; Alexander Marson ; Julia CarnevaleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrimary human myeloid cells are promising candidates for immunotherapy, yet efficient and scalable technologies for genetic engineering and screening in these cells are limited. Here we prese […]
- GSE327352 Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells [RNA-seq Exp2] April 8, 2026Contributors : Pascal Devant ; Hyuncheol Jung ; Alexander Marson ; Julia CarnevaleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrimary human myeloid cells are promising candidates for immunotherapy, yet efficient and scalable technologies for genetic engineering and screening in these cells are limited. Here we prese […]
- GSE327354 Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells [RNA-seq Exp3] April 8, 2026Contributors : Pascal Devant ; Hyuncheol Jung ; Alexander Marson ; Julia CarnevaleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrimary human myeloid cells are promising candidates for immunotherapy, yet efficient and scalable technologies for genetic engineering and screening in these cells are limited. Here we prese […]
- GSE327357 Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells [RNA-Seq Exp1] April 8, 2026Contributors : Pascal Devant ; Hyuncheol Jung ; Alexander Marson ; Julia CarnevaleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrimary human myeloid cells are promising candidates for immunotherapy, yet efficient and scalable technologies for genetic engineering and screening in these cells are limited. Here we prese […]
- GSE261506 Single-cell transcriptional profiling of lung epithelial cells after naphthalene club cell injury in adult C57 Bl/6 mice with temporal resolution April 8, 2026Contributors : Irene G Wong ; Carla F Kim ; Margherita PaschiniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe aim of this study was to study tissue-wide responses to club cell airway injury.Keywords: Expression profiling by high throughput sequencing