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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE300115 The Ly6Ghigh neutrophil subset occupying the early metastatic niche dictates breast cancer lung metastasis via cathelicidin-induced CD8+ T cell death_neutrophil March 12, 2026Contributor : Rui WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung metastasis is a leading cause of breast cancer (BC)-related mortality, driven by the immunosuppressive traits of the metastatic tumor microenvironment. However, the mechanisms underlying cell-cell crosstalk in shaping immune evasion within the me […]
- GSE296421 Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer [ATAC-seq] March 12, 2026Contributors : Liliana Garcia-Martinez ; Mengsheng Zha ; Rodrigo L Borges ; Tong Liu ; Gretter González-Blanco ; Hao Zhu ; Zheng Wang ; Lluis MoreySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChromatin architecture plays a key role in development and cancer, yet most studies lack mechanistic depth due t […]
- GSE303457 TET3-mediated DNA demethylation contributes to the formation of stable epialleles in tomato March 12, 2026Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Solanum lycopersicumThis SuperSeries is composed of the SubSeries listed below.
- GSE302056 5’tRNA-derived fragments modulate 𝛽-cell homeostasis and islet macrophage activation in type 2 diabetes [iMAC] March 12, 2026Series Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusDuring obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of transfer RNAs (tRNAs) generates tRNA-deriv […]
- GSE261438 TERT expression attenuates metabolic disorders in obese mice by promoting adipocyte formation and remodeling macrophage landscape [RNA-Seq] March 12, 2026Contributors : Laura Braud ; Manuel Bernabe ; Julien Vernerey ; Dmitri Churikov ; Manon Richaud ; Antonio M Miranda ; Liam Mc Allan ; Christophe Lachaud ; Jesus Gil ; William Scott ; Vincent GeliSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity is linked to limited adipose tissue (AT) remodeling capacity, leading […]
- GSE304300 RNA sequencing of aortic valves from dialysis and non-dialysis patients with aortic stenosis March 12, 2026Contributors : Satoru Shiraiwa ; Tran Nguyen ; Yosuke Watanabe ; Tsuyoshi Kobayashi ; Atsuhito Nakao ; Akira Sato ; Hiroyuki NakajimaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPatients with aortic stenosis (AS) undergoing hemodialysis (HD) often experience faster disease progression and poorer prognosis than non-di […]
- GSE323395 A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination [END-seq] March 12, 2026Contributors : Jansirani Srinivasan ; Jianbin WangSeries Type : OtherOrganism : Oscheius tipulaeProgrammed DNA Elimination (PDE) is an exception to the paradigm of genome integrity, removing selected DNA sequences during development. PDE is observed in hundreds of metazoan species from diverse phyla, but its molecular mechanisms and biological significance i […]
- GSE279616 The effect of intrauterine growth restriction on the developing pancreatic immune system March 12, 2026Contributors : Thea Golden ; James P Garifallou ; Colin C Conine ; George S Worthen ; Rebecca A SimmonsSeries Type : Expression profiling by high throughput sequencingOrganism : RattusImmune cells in the pancreas are known to participate in organ development and homeostasis. However, the resident pancreatic immune system has yet to be fully defined. Immune c […]
- GSE323397 A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination [CRISPR] March 12, 2026Contributors : Jansirani Srinivasan ; Jianbin WangSeries Type : OtherOrganism : Oscheius tipulaeProgrammed DNA Elimination (PDE) is an exception to the paradigm of genome integrity, removing selected DNA sequences during development. PDE is observed in hundreds of metazoan species from diverse phyla, but its molecular mechanisms and biological significance i […]
- GSE323396 A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination [Hi-C] March 12, 2026Contributors : Jansirani Srinivasan ; Jianbin WangSeries Type : OtherOrganism : Oscheius tipulaeProgrammed DNA Elimination (PDE) is an exception to the paradigm of genome integrity, removing selected DNA sequences during development. PDE is observed in hundreds of metazoan species from diverse phyla, but its molecular mechanisms and biological significance i […]
- GSE324226 Gut–brain axis disruption sustains low intake syndrome in weanling pigs March 12, 2026Contributors : Laia Ferreres-Serafini ; Hubèrt Van Hees ; Susana M Martín-Orúe ; José F Pérez ; Tetske G Hulshof ; Laura M Payling ; Lluís FabàSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaAbrupt weaning imposes highly variable physiological stress on pigs, yet the mechanisms underlying this variability remain poorly un […]
- GSE324266 Transcriptomic profiling of plants in response to CLE9 treatment March 12, 2026Contributors : Yuanyuan Zhou ; Jiaojiao Bai ; Dongping LuSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianawe performed RNA sequencing (RNA-seq) to analyze genes that were differentially expressed upon CLE9 treatment.A total amount of 3 µg RNA per sample was used as input material for the RNA sample preparations. […]
- GSE324285 Total RNA Sequencing analysis of total RNA and RNA isolated from mitochondrial pellets in CSDE1-knockdown sensory neurons March 12, 2026Contributors : Ho-Yong Jin ; Yong-Cheol ChoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCSDE1 is an RNA-binding protein that associates with a subset of mitochondria-related transcripts. We previously observed that RNAs encoding mitochondrial proteins localized to the mitochondrial inner membrane (MIM), intermembrane […]
- GSE292514 Mechanisms and mouse modeling of tumor dormancy through distinct immune niche formation [D2A1] March 12, 2026Contributors : Abdul Ahad ; Vishal Koparde ; Jae Young So ; Li YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInvestigate molecular mechanisms of tumor dormancy with myeloid-specific TGFBR2-KO mouse model.
- GSE323393 A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination [CUT&Run] March 12, 2026Contributors : Jansirani Srinivasan ; Jianbin WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Oscheius tipulaeProgrammed DNA Elimination (PDE) is an exception to the paradigm of genome integrity, removing selected DNA sequences during development. PDE is observed in hundreds of metazoan species from diverse phyla, […]