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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE294821 The study investigates the function of the nphp4 gene in the testes of medaka fish (Oryzias latipes) March 10, 2026Contributors : Tiansheng Chen ; Jingjie Liang ; Jiangling LiSeries Type : Expression profiling by high throughput sequencingOrganism : Oryzias latipesIn this study, we employed CRISPR-Cas9 genome editing to generate nphp4 knockout medaka fish. By comparing the transcriptomic profiles of the testes from wild-type (WT) and nphp4-/- mutants, we conducted a comp […]
- GSE291596 Co-targeting CDK2 and CDK9 inhibits MYC oncogenic programs and has anti-tumor effects in CIC-rearranged sarcoma March 10, 2026Contributor : Schaefer Inga-MarieSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCIC-rearranged sarcoma is an aggressive mesenchymal neoplasm characterized by capicua (CIC) gene rearrangement and molecular dependence on the CDK2-cyclin E complex. Given its high metastatic potential and poor clinical outcomes, there is a […]
- GSE300408 Motor learning drives region-specific transcriptomic remodeling in the motor cortex and dorsal striatum March 10, 2026Contributors : Sun Yue ; Ding JunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMotor learning depends on coordinated activity across the motor cortex (M1) and dorsal striatum (dSTR), yet the molecular mechanisms driving learning-related synaptic and circuit remodeling remain unclear. Here, we combine activity-dependen […]
- GSE296640 Blood vessel-resident macrophages safeguard blood and vessel integrity in zebrafish March 10, 2026Contributors : Catherine Robin ; Bart WeijtsSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioMacrophages are essential in immune defence, tissue development and maintenance, and are involved in disease onset and progression. Their function is influenced by their microenvironment and origin. While tissue-resident macrophag […]
- GSE308015 Cooperation between architectural C2H2 proteins in CP190 recruitment to Drosophila regulatory elements [RNA-Seq] March 10, 2026Contributors : Oksana Maksimenko ; Natalia KlimenkoSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterCTCF is the best-studied architectural protein that is highly conserved among animals, including Drosophila and mammals. In Drosophila, CTCF is involved in the organization of functional promoters and insulators […]
- GSE304781 Detection of statistically robust interactions from diverse RNA-DNA ligation data March 10, 2026Contributors : Simonida Zehr ; Sandra Seredinski ; Katalin Pálfi ; James A Oo ; Emma C Walsh ; Alessandro Bonetti ; Matthias S Leisegang ; Ralf P Brandes ; Marcel H Schulz ; Timothy WarwickSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChromatin-localized RNAs play diverse roles in gene regulation and nuclear architect […]
- GSE324069 Transcriptomics and experiments verified that astaxanthin reduces the apoptosis of nerve cells in ischemic stroke by inhibiting the toll-like receptor signaling pathway March 10, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBackground and Objective. Inflammation is an important pathological process in ischemic stroke (IS). Astaxanthin (ATX) is a natural product with neuroprotection effects. However, the mechanism of ATX on anti-inflammatory after IS is not clear. The aim of this study wa […]
- GSE324430 Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects [RNA-seq] March 10, 2026Contributors : Rebecca M Hauser ; Nicholas CochranSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTau neurofibrillary tangles are a hallmark of several neurodegenerative diseases called tauopathies, including frontotemporal dementia and Alzheimer's Disease. Ongoing clinical trials for tauopathies seek to reduce Tau […]
- GSE324265 Contribution of cytotoxic CD8 T cells, neutrophils and type 1 interferon signaling to hyperinflammatory pathology in HIV associated TB meningitis [RNA-Seq] March 10, 2026Contributors : James Barnacle ; Nonzakazi Bangani ; Hubert Slawinski ; Christopher Barrington ; Katalin Wilkinson ; Cari Stek ; Rachel Lai ; Graeme Meintjes ; Brian Robertson ; Martin Gengenbacher ; Angharad Davis ; Daniel Barber ; Anne O'Garra ; Robert J WilkinsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImm […]
- GSE324247 Effects of Rg3@PACVs with NIR in a Rat Model of Pulmonary Ischemia–Reperfusion Injury March 10, 2026Contributors : Haoxiang Yuan ; Bo Zeng ; Pu Shen ; Jiancheng Deng ; Ying Chen ; Meiyu Huang ; Wentao Wu ; Xin Xu ; Xuanlin Zhang ; Xue Liu ; Xudong Zhang ; Zhijin Fan ; Jianxing HeSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPulmonary ischemia–reperfusion injury (IRI) is characterized by excessive inflammation, […]
- GSE324288 Genetic deletion of cytoglobin exacerbates cardiac hypertrophy and inhibits cardiac fibroblast activation independent of changes in blood pressure March 10, 2026Contributors : Le Gia Cat Pham ; Kurrim Gilliard ; Frances Jourd'heuil ; Sarahann Mistretta ; John J Schwarz ; Harold A Singer ; David Jourd'heuilSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHypertension-mediated left ventricular hypertrophy and cardiac fibrosis often precede heart failure. Recent studies i […]
- GSE324337 Adenosine-specific transcriptional programs in murine connective tissue type mast cells March 10, 2026Contributors : Qihua Liang ; Volodymyr Tsvilovskyy ; Anouar Belkacemi ; Merima Bukva ; Christin Richter ; Nicole Ludwig ; Andreas Keller ; Marc FreichelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMast cells are tissue-resident immune cells that are critical for the pathogenesis of allergic and inflammatory disorders […]
- GSE324361 Distribution of big tau isoforms in the human central and peripheral nervous system March 10, 2026Contributors : Joshua Orrick ; Chiara Pedicone ; Alison GoateSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis project aims to characterize the distribution of “big tau,” a longer tau isoform expressed in the peripheral nervous system (PNS) and select central nervous system (CNS) regions, and to examine its relations […]
- GSE286616 Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling [RNA-Seq] March 10, 2026Contributors : Ellen Foxman ; Bao WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Human rhinovirus 1ARhinovirus (RV) is the most frequent cause of common colds, but also a major cause of serious respiratory illness in high-risk groups (e.g. smokers and asthmatics). The molecular mechanisms leading to disparate ou […]
- GSE324044 Contribution of cytotoxic CD8 T cells, neutrophils and type 1 interferon signaling to hyperinflammatory pathology in HIV associated TB meningitis March 10, 2026Contributors : Barnacle James ; Bangani Nonzakazi ; Slawinski Hubert ; Barrington Christopher ; Wilkinson Katalin ; Stek Cari ; Lai Rachel ; Meintjes Graeme ; Robertson Brian ; Gengenbacher Martin ; Davis Angharad ; Barber Daniel ; O'Garra Anne ; Wilkinson Robert JSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImm […]