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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE274289 Single cell analysis of a iPSC-derived glial-neurons triculture model of mitochondrial unfolded protein response (UPRmt) activation. March 9, 2026Contributors : Maria Jose Perez J. ; Michela DeleidiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMitochondria have developed a specialized unfolded protein response (UPRmt) to maintain proteostasis and promote recovery under stress conditions. Research in simpler organisms has demonstrated that UPRmt activation in gl […]
- GSE291780 YAP Induces a Pro-Renewal Metabolic State in Cardiomyocytes: Cardiomyocyte-enriched Datasets March 9, 2026Contributors : Jeffrey D Steimle ; Lin Liu ; James F MartinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCardiomyocyte (CM) maturation is characterized by a change in energy metabolism from glucose to fatty acid catabolism, which poses a barrier to CM proliferation and cardiac regenerative repair. YAP, a transcription […]
- GSE285762 Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility (Bulk-RNAseq) March 9, 2026Contributors : Jeremie Rispal ; Dedeepya Vaka ; Dario Boffelli ; Ophir KleinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe gut epithelium exhibits regional specialization critical for its function and susceptibility to disease, as gut diseases localize to specific regions of the organ. However, how regionalization […]
- GSE299051 Immune Dynamics in Palmoplantar Pustulosis Unveiled by Single-Cell and High-Resolution Spatial Transcriptomics [Spatial Transcriptomics] March 9, 2026Series Type : OtherOrganism : Homo sapiensPalmoplantar pustulosis (PPP) is a chronic and relapsing inflammatory skin disorder marked by the appearance of sterile pustules on the palms and/or soles, with an underlying pathogenesis that remains only partially understood. In this study, we mapped the immune landscape underlying PPP progression using single-cell […]
- GSE295698 Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins March 9, 2026Contributors : Roberta Carloni ; Tadhg Devlin ; Pin Tong ; Tania Auchynnikava ; Christos R Spanos ; Juri Rappsilber ; Keith R Matthews ; Robin C AllshireSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Trypanosoma brucei bruceiKinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main […]
- GSE310446 Exposed phosphatidylserine is a non-classical inhibitory molecule during CD8 T cell exhaustion [scRAN-seq] March 9, 2026Contributors : Christopher B Medina ; Rafi AhmedSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn cancer and chronic infection CD8 T cell exhaustion is hallmarked by expression of inhibitory surface receptors such as PD-1, TIM-3, CTLA-4, LAG-3, and TIGIT. Thus, inhibitory receptor focus has been limited to surface expr […]
- GSE307710 Two LEAFY homologues regulate floral patterning and development without affecting flowering time in kiwifruit March 9, 2026Contributors : Yongyan Peng ; Charlotte Voogd ; Cecilia Deng ; Mikaela Douglas ; Bo Yang ; Tianchi Wang ; Andrew Allan ; Erika Varkonyi-Gasic ; Joanna PutterillSeries Type : Expression profiling by high throughput sequencingOrganism : Actinidia chinensisActinidia chinensis (kiwifruit) are economically important fruit-bearing woody perennial vines, but with a […]
- GSE322526 PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress March 9, 2026Contributors : Richard D Kelly ; Claire Wilson ; Aditi Kanhere ; Eva PetermannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE322525 PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq] March 9, 2026Contributors : Richard D Kelly ; Claire Wilson ; Aditi Kanhere ; Eva PetermannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOncogenic RAS activation, hypertranscription and transcription-replication conflicts (TRCs) are frequent features of cancer cells that are under investigation for therapeutic targeting. RAS oncog […]
- GSE322807 Mild cold exposure mitigates ischemic heart injury through indole-3-acetamide–AHR-mediated SMAD2 proteolysis March 9, 2026Contributors : Lei Li ; Ying WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAmbient temperature profoundly influences organismal metabolism, physiology, and disease. While cold exposure is a well-recognized risk factor for the onset of myocardial infarction (MI), its impact on the injured heart after MI remains une […]
- GSE322743 Expression data from WT and Hela S3 cells March 9, 2026Contributors : Gongjie Wu ; Ferdinand KappesSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe goal of this study was to define how loss of full-length DEK reshapes global transcriptional programs in HeLa S3 cells by comparing gene-expression profiles of wild-type (WT) HeLa S3 and the 1E7 DEK-knockout cells generated by TALEN-mediated geno […]
- GSE322964 Single cell and spatial sequencing analysis of cancer associated fibroblasts in the brain metastasis tumor microenvironment [Multiome] March 9, 2026Contributors : Thomas Simon ; David N Buckley ; Zeyi Yang ; Chikako Matsuba ; Ben Y Tew ; Gerald C Gooden ; Kyle Hurth ; Steven A Toms ; David D Tran ; Gabriel Zada ; Matthew P Salomon ; Bodour SalhiaSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensBrain […]
- GSE323317 Pseudomonas isolates reconfigure gene expression in walnut seedlings exposed to salt stress March 9, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Juglans regiaTo understand the potential mechanisms underlying the effects of the four Pseudomonas strains P1, P2, P3, and P4 on the growth and salt tolerance of walnut trees, the transcriptomic responses of walnut seedlings inoculated with these isolates under conditions of salt stre […]
- GSE323362 Phage-encoded CasPRs transcriptionally silence diverse CRISPR-Cas systems [ChIP-seq] March 9, 2026Contributors : Edith M Sanderson ; Julieta Peralta ; Sam Nouwens ; Luke Oriolt ; Victoria M Hayes ; Brett K Kaiser ; Alexander J MeeskeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Listeria seeligeriAnti-CRISPRs (Acrs) are diverse proteins or RNAs that protect invading phages and plasmids from host CRISPR-Cas immuni […]
- GSE271500 Small RNA sequencing of serum identifies circulatory microRNAs as biomarkers of coronary artery disease March 9, 2026Contributors : Raj Rajeshwar Choudhury ; Harshi Gupta ; Sudha Bhushan ; Archna Singh ; Ambuj Roy ; Neeru SainiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensCoronary artery disease (CAD) remains the leading cause of morbidity in developing countries like India. It is crucial to identify reliable biomarkers for earl […]