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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE291333 The iPSC-derived pulmonary epithelial cells in micro-patterned culture plate February 18, 2026Contributors : Yusuke Tsutsui ; Taro Tsujimura ; Shimpei Gotoh ; Takuya YamamotoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe established a system of generating alveolar or airway organoids in a micro-patterned culture plate. In this system, various lung cell types were identified, depending on the cu […]
- GSE289679 Modeling of spontaneous pulmonary fibrosis via cellular senescence in type 2 alveolar epithelial cells derived from human iPSCs [epithelial] February 18, 2026Contributors : Yusuke Tsutsui ; Shimpei Gotoh ; Takuya YamamotoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTelomere dysfunction in type II alveolar epithelial (AT2) cells causes pulmonary fibrosis in a subset of patients. TRF2 is a key component of the shelterin complex (SC) which prevents abnormally shortened and u […]
- GSE299761 METTL5 Blockade Enhances Anti-Tumor Immune Response via Inducing Neoantigen Generation February 18, 2026Contributors : Yangyi Zhang ; Xiaoyan Shi ; Hao ChenSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusTumor neoantigens play a pivotal role in immunotherapy through eliciting tumor-specific immune responses. However, their clinical application is limited by the restricted repertoire of naturally occurring neoantig […]
- GSE294803 Effect of cardiomyocyte-specific activation of nuclear receptor subfamily 4 group A member 2 (NR4A2) on the regulation of gene expression in the mouse heart [ChIP-Seq] February 18, 2026Contributors : Harmancey Romain ; Ashraf SadiaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusNuclear receptor subfamily 4 group A member 2 (NR4A2) is a widely expressed immediate early gene induced by a host of physiological signals such as growth factors, cytokines, and neurotransmitters. In the adult ma […]
- GSE222243 Extruding transcription elongation loops observed in high-resolution single-cell 3D genomes [Smart-seq2, GM12878] February 18, 2026Contributors : Honggui Wu ; Jiankun Zhang ; Longzhi Tan ; Sunney XieSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInside human nuclei, genes are transcribed within a highly packed genome, whose organization is facilitated by cohesin-mediated loop extrusion. However, how cohesin folds transcribed genes and affects tran […]
- GSE303929 Comparative Transcriptomic Analysis of Embryonic Hearts in Atf4 Exon 2 and Exon 2–3 Conditional Knockout Mice February 18, 2026Contributors : Zengming Zhang ; Tongbin Wu ; Zeyu Chen ; Ju ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis dataset comprises RNA sequencing (RNA-seq) profiles of E11.5 embryonic hearts from two Atf4 conditional knockout (cKO) mouse models, targeting different exons of the gene. In one model, exons 2 and 3 were […]
- GSE319724 The alarmone pGpp inhibits translation through GTP depletion I February 18, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Bacillus subtilis subsp. subtilis str. 168Bacteria produce the alarmone nucleotides ppGpp and pppGpp during stress to affect replication, transcription, and metabolism. ppGpp and pppGpp also attenuate translation by competitively binding translational GTPases to conserve resources dur […]
- GSE260530 Distinct Roles for SETα and SETβ in Early Cell Fate Decisions [RNA-Seq] February 18, 2026Contributors : Patrick S Lim ; Eran MeshorerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSET, the nuclear proto-oncogene, is primarily expressed as SETα in embryonic stem cells. Upon pluripotency exit, a transcriptional switch driven by alternative promoters causes SETβ to largely replace SETα expression. Functional […]
- GSE319736 Early-Life Odor Exposure Rewrites Innate Aversion through a Frizzled1-Regulated Critical Period February 18, 2026Contributors : Yunming Wu ; Limei Ma ; Qiang Qi ; Davin Marro ; Ai Fang ; Wenjing Xu ; Aviral Misra ; Jillian Blanck ; Allison Scott ; Shiyuan Chen ; Huzaifa Hassan ; Timothy Corbin ; Andrea Moran ; Kate Hall ; Hua Li ; Anoja Perera ; C R YuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAnimals are born with innate mec […]
- GSE319727 The alarmone pGpp inhibits translation through GTP depletion II February 18, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Bacillus subtilis subsp. subtilis str. 168Bacteria produce the alarmone nucleotides ppGpp and pppGpp during stress to affect replication, transcription, and metabolism. ppGpp and pppGpp also attenuate translation by competitively binding translational GTPases to conserve resources dur […]
- GSE319751 An ancient monoaminergic signaling system coordinates contractility in a nerveless sponge February 18, 2026Contributors : Rong Xuan Zang ; Jamie D Maziarz ; Jacob M MusserSeries Type : Expression profiling by high throughput sequencingOrganism : Spongilla lacustrisChemical neurotransmission was a key animal innovation, enabling multicellular coordination of physiology and locomotion. Sponges are early-diverging animals that lack neurons and muscles, yet still coo […]
- GSE319829 Asymmetry and redundancy of STAT5 paralogs across CD8+ T cell differentiation states February 18, 2026Contributors : Svetlana Ristin ; Molly Dalzell ; Christopher Armstrong ; Nisa Ilsin ; Antonio M Fontanella ; Luis Nivelo ; Lothar Hennighausen ; John J O’Shea ; Alejandro V VillarinoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFostering STAT5 signaling is key to immunotherapies that leverage CD8+ T cell biology. Usin […]
- GSE319840 Patient-derived cell lines unveil COL1A2 as a predictor of docetaxel resistance in breast cancer February 18, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBreast cancer is the most common type of malignant tumour among women globally, with a major cause of cancer-related mortality worldwide. Chemoresistance presents a significant challenge in breast cancer therapy and serves as the primary factor contributing to tumour recur […]
- GSE283571 Circadian reprogramming of protein homeostasis and glycolipid metabolism in diabetic nephropathy February 18, 2026Contributors : Xiao-Qian Li ; Lei Cheng ; Tian-Fen Chen ; Lu-Yao Wang ; Yi-Nuo Ma ; Xiao-Hui Li ; Ting-Yu Fu ; Jing Xiao ; Zhan-Zheng ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground Dysfunction of the circadian clock has been implicated in the pathogenesis of a variety of diseases, including metabolic dis […]
- GSE319683 A novel Adnp frameshift variant disrupts Wnt signaling leading to chromatocytoskeletal defects and autism-related behavior in mice February 18, 2026Contributors : Claudio Peter D’Incal ; Elisa Cappuyns ; Flora Paldi ; Mathijs B van der Lei ; Dale John Annear ; Clara Milián Alastruey ; Frank KooySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Heterozygous de novo variants in the transcription factor Activity-Dependent Neuroprotective Protein (ADNP) cause […]