Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE264319 Profiling Immune-Independent Response to Immune Checkpoint Inhibitors on Stem Cell-derived Cardiac Organoids [scRNA-seq] February 9, 2026Contributors : Dilip Thomas ; Yu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe use of antibody based immune-checkpoint inhibitors (ICIs) have been highly successful in clinical treatment of several cancers. Despite the compelling efficacy of these drugs with their high binding affinity, there is incomplete unde […]
- GSE318797 CosMX spatial transcriptomics of mouse subcutaneous EO771 tumors to study synergistic effects of NEDD8 depletion and anti-PD-1 therapy February 9, 2026Contributors : Papakyriacou Irineos ; Lu Yonglin ; Bedos Marta Rubies ; Jarvius Malin ; Lapins Maris ; Puigvert Jordi Carreras ; Mao YuMaoSeries Type : OtherOrganism : Mus musculusWe have established the phenotype that depletion of NEDD8 in tumor cell has synergestic effect with anti-PD1 therapy in mouse EO771 subcutaneous tumor model. In this study we perfo […]
- GSE288812 Epi-transcriptome analysis reveals the absence of m6A modifications in two watermelon-infected RNA viruses [m6ARIPseq] February 9, 2026Contributors : Fuan Pan ; Jiaxian Jing ; Xueping Zhou ; Shaofang LiSeries Type : OtherOrganism : Citrullus lanatusWe carried m6ARIP-seq with ribo-minus RNAs extracted from virus-infected watermelon leaves and the corresponding IVT RNAs to evaluate m6A enrichment on viral RNAs.
- GSE281614 RNA-mediated MYC multimerization suppresses innate immune signaling [mRNA] February 9, 2026Contributors : Sinah Löbbert ; Toshitha Kannan ; Martin EilersSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn response to perturbed transcription elongation or splicing, MYC proteins multimerize and undergo a phase transition; the underlying mechanisms and the biological function of this transition are poorly underst […]
- GSE292272 EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology February 9, 2026Contributors : Alan Monziani ; Igor UlitskySeries Type : Other ; Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMammalian genomes are pervasively transcribed into long noncoding RNAs (lncRNAs), whose functions and modes of action remain poorly understood. EPB41L4A-AS […]
- GSE289097 IRF7 Modulates Inflammatory Pain through upregulating IFNβ in mice February 9, 2026Contributors : Shilin Jia ; Lijia Mai ; Fang Huang ; Wenguo FanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInterferon regulatory factors (IRFs) are a family of transcription factors and function primarily in the immune system, which also play critical roles in other biological processes, such as pain. To date little […]
- GSE318326 Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation. February 9, 2026Contributors : Deepta Bhattacharya ; Colin FieldsSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensUpon activation, B cells undergo profound transcriptional, epigenetic, and metabolic reprogramming to form antibody secreting plasma cells bearing little res […]
- GSE297980 Transcriptional and cellular maturation of the chick spinal cord in the context of distinct neuromuscular circuits February 9, 2026Contributors : Fabio Sacher ; Bianka Berki ; Antoine Fages ; Maëva Luxey ; Patrick TschoppSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusThe chicken spinal cord is a classic model system to study the early specification of neuronal cell types along its anterior-posterior axis. Here, we follow the ensuing maturation dy […]
- GSE318418 Immunosuppressive monocytes are enriched in hepatocellular carcinoma patients with liver dysfunction in a phase II trial of combination sorafenib and nivolumab [scRNA-Seq] February 9, 2026Contributors : Bridget P Keenan ; Zenghua Fan ; Bryan Khuong Le ; Quincy Harris ; Jocelin Chen ; Matthew Clark ; Averey Lea ; Li Zhang ; Alexander Cheung ; Frances Lara ; John D Gordan ; Paige Bracci ; Spencer C Behr ; Lawrence Fong ; Alan P Venook ; Edward J Kim ; Robin K KelleySeries Type : Expression profiling by high throughput sequencingOrganism : Homo […]
- GSE318377 Effects of Short-Wavelength Light on Retinal Cell Development February 9, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChanges in the light environment exert a profound impact on vision; however, the specific mechanisms underlying their effects on retinal development remain poorly understood. In this study, we exposed mice to short-wavelength light from eye opening and performed single-cel […]
- GSE318493 Sialylated CD43 forms a glyco-immune barrier that restrains anti-leukemic immunity February 9, 2026Contributors : Jooho Chung ; Mounica Vallurupalli ; Ashwin V Kammula ; Todd R Golub ; Robert T MangusoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMacrophages exert anti-tumorigenic activity through phagocytosis, but phagocytosis-enhancing therapeutics have not improved acute myeloid leukemia (AML) outcomes. To ident […]
- GSE318550 Early events in transcription and genome organization after STAG2 reconstitution in human cancer cells [Hi-C] February 9, 2026Contributors : Tianyi Yang ; Jung-Sik Kim ; Clara Mellows ; Wanying Xu ; Alvin Ya ; Lisa Sadzewicz ; Luke Tallon ; Jann Sarkaria ; Fulai Jin ; Todd WaldmanSeries Type : OtherOrganism : Homo sapiensTruncating mutations of the tumor suppressor gene STAG2, encoding a component of the chromatin-bound cohesin complex, are present in many human cancer types. Here […]
- GSE318552 Early events in transcription and genome organization after STAG2 reconstitution in human cancer cells [RNA-Seq] February 9, 2026Contributors : Tianyi Yang ; Jung-Sik Kim ; Clara Mellows ; Wanying Xu ; Alvin Ya ; Lisa Sadzewicz ; Luke Tallon ; Jann Sarkaria ; Fulai Jin ; Todd WaldmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTruncating mutations of the tumor suppressor gene STAG2, encoding a component of the chromatin-bound cohesin complex, […]
- GSE301035 SETD2 methyltransferase activity aids gene definition by promoting correct transcription initiation and efficient pre-mRNA 3’ cleavage [RCC_3mRNAseq] February 9, 2026Contributors : Magda Kopczyńska ; Chihiro Nakayama ; Agata Stępień ; Shoko Ito ; Koshi Imami ; Michal R Gdula ; Takayuki Nojima ; Kinga Kamieniarz-GdulaSeries Type : OtherOrganism : Homo sapiensSETD2 is a key histone methyltransferase responsible for depositing histone H3 lysine 36 trimethylation (H3K36me3). Loss of its enzymatic activity has been implicated […]
- GSE318289 Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency February 9, 2026Contributors : Melissa Vos ; Philip Seibler ; Christine KleinSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterBackground: X-linked dystonia-parkinsonism (XDP), an adult-onset neurodegenerative disorder, is caused by an SVA insertion in the TAF1 gene, containing a hexanucleotide, the length of which is correlat […]