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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE302249 Association of Tumour-Associated Macrophage States with Non-conserved lncRNAs in Lung Cancer January 26, 2026Contributors : Yvessa Verheyden ; Sonia Cinque ; Daliya Kancheva ; Jo Van Ginderachter ; Eleonora LeucciSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumour-associated macrophages (TAMs) are central players in the tumour microenvironment, driving cancer progression and modulating immune responses. Renowned for their a […]
- GSE255514 Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators [Bulk RNA-seq] January 26, 2026Contributors : Feifei Zhang ; Ryan D Chow ; Chuanpeng Dong ; Emily He ; Lvyun Zhu ; Shan Xin ; Daniyal Mirza ; Yanzhi Feng ; Xinyu Ling ; Qin Han ; Sidi Chen ; Guangchuan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe hostile tumor microenvironment (TME) is major challenge for cancer immunotherapies. Here, we d […]
- GSE208743 Trans-acting long non-coding RNA modulates long-range chromatin interactions associated with oncogenic MYC signaling [Iso-Seq] January 26, 2026Contributors : Tingyou Wang ; Yanan Ren ; Rendong YangSeries Type : OtherOrganism : Homo sapiensTo investigate the function and affected pathways of novel lncRNA IGF1R-AS1 in the prostate cancer, we established VCaP cell lines in which IGF1R-AS1 has been knocked down by siRNA.
- GSE277797 Multi-omic profiling unveils molecular landscapes and heterogeneous tumor microenvironment in sinonasal squamous cell carcinoma [snMultiome-seq] January 26, 2026Contributors : Chaelin You ; Jihwan Park ; Keunsoo Kang ; Jaewoo Park ; Jungyeon Jang ; Myeongsang Yu ; Yoosam Chung ; Jiheui Kim ; Kyuho KangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSinonasal squamous cell carcinoma (SNSCC) is a rare and aggressi […]
- GSE266909 Transcriptome data (mRNA-seq) for Chlamydomonas reinhardtii wild type. January 26, 2026Contributors : Jiachen Wang ; Jiabing Wu ; Kangxi Du ; Wenhao Xie ; Xiang Li ; Xiaolong Wu ; Aiwu DongSeries Type : Expression profiling by high throughput sequencingOrganism : Chlamydomonas reinhardtiiGene expression profiling analysis of RNA-seq data for Chlamydomonas reinhardtii.
- GSE295351 Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets [bulk_islet] January 26, 2026Contributors : Maria S Hansen ; Christopher J Hill ; Lori Sussel ; Kristen L WellsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goal of this study was to optimize single-cell long-read RNA sequencing in pancreatic islets to enable accurate isoform-level gene expression analysis. We aimed to overcome key technical […]
- GSE291427 Nucleoli-localized KANSL2 as an epigenetic regulator of ribosome biogenesis in glioblastoma cells. January 26, 2026Contributors : Nicolás Budnik ; Carolina Perez-CastroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKANSL2 is a subunit of the non-specific lethal (NSL) chromatin-modifying complex involved in epigenetic reprogramming and plays a critical role in tumorigenesis of glioblastoma (GBM), by enriching the GBM stem-like cell […]
- GSE317110 Microbiome analysis of control, radiation enteritis model, and treatment groups in rat stool samples using 16S rRNA sequencing January 26, 2026Contributors : Lingzhang Meng ; Donglin ZhengSeries Type : OtherOrganism : Rattus norvegicusThis study investigates the gut microbiome composition and diversity in three groups of rats: control, radiation enteritis model, and treatment (TG) groups. Total DNA was extracted from stool samples, PCR-amplified targeting 16S rRNA gene variable regions, and sequenc […]
- GSE317084 Transcriptome analysis of Arabidopsis thaliana seedlings after combined isoxaben and PEP3 treatment January 26, 2026Contributors : Richard N Morton ; Timo EngelsdorfSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaCell wall damage causes the induction of plant signaling. Here, we used isoxaben treatment to inhibit cellulose biosynthesis and cause cell wall damage. PEP3 is detected by PEPR receptors and contributes to both plan […]
- GSE317222 The effect of lncRNA GAS5 on lens epithelial cells January 26, 2026Contributor : Deqian KongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThrough transcriptome sequencing screening, it was found that knocking down GAS5 significantly disrupted the mRNA expression of key factors related to aging secretion phenotype, cell cycle inhibitory proteins, and antioxidant enzymes.
- GSE317178 Nanoluciferase-CD63 labeling reveals extracellular vesicle kinetics in a mouse intraductal model of ductal carcinoma in situ January 26, 2026Contributors : Hladik Cole ; Hannafon BethanySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground. Ductal carcinoma in situ (DCIS) is a non-invasive precursor to breast cancer that increases lifetime risk for invasive disease and, in rare cases, causes distant metastases without local recurrence. Tumor-derived sma […]
- GSE317223 Exercise-Derived Exosomal miR-151-3p: An Innovative Anti-inflammatory and Antioxidant Exerkine for Spinal Cord Injury January 26, 2026Contributors : Xinwang Ying ; Jiamen Shen ; Yanfang Zhao ; Tiantaixi Tu ; Yi Jiang ; Zhiyang Huang ; Qingfeng XieSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Rattus norvegicusExercise (Exe) training serves as the hub of the multimodal treatment system for spinal cord (SC) injury (SCI), with well-established efficacy. However […]
- GSE317235 SAGA/ATAC complexes sustain aberrant chromatin regulation and metabolic programs in diffuse midline glioma January 26, 2026Contributors : Rosemary Richard ; Akdes Serin-Harmanci ; Jamie N. AnastasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDiffuse midline gliomas (DMG) are aggressive pediatric brain tumors characterized by chromatin and transcriptional dysregulation induced by H3K27M mutations. Strategies for overcoming epigenetic dysfu […]
- GSE317377 S-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1 January 26, 2026Contributors : Xinhao Qiao ; Ting Xie ; Chang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAge-related obesity is a growing public health concern linked to various metabolic disorders, yet its underlying mechanisms remain incompletely understood. Here we report that S-nitrosoglutathione reductase (GSNOR), a pivot […]
- GSE298482 Induction of a renal developmental cell state is associated with chemotherapy resistance in favorable-histology Wilms tumor [HiC] January 26, 2026Contributors : Andrew J Murphy ; Hongjian Jin ; Beisi Xu ; Carolyn JablonowskiSeries Type : OtherOrganism : Homo sapiensChildren with favorable histology Wilms tumor (FHWT) who experience disease relapse or whose tumors exhibit blastemal predominance after chemotherapy often have poor outcomes. We established a FHWT patient-derived xenograft model, KT-47, th […]