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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE281142 Cocaine, via ΔFosB, remodels gene expression and excitability in ventral hippocampus January 10, 2026Contributors : Andrew L. Eagle ; Marie A. Doyle ; Chiho Sugimoto ; Megan Dykstra ; Hayley M. Kuhn ; Ian Maze ; Michelle S. Mazei-Robison ; Alfred J. RobisonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusVentral hippocampus (vHPC) CA1 pyramidal neurons send glutamatergic projections to nucleus accumbens (NAc), and this […]
- GSE294787 Effect of recombinant human CD26/DPPIV protein or Sitagliptin (DPPIV enzyme inhibitor) on CD3 T cells at day 2 after in vitro cell culture January 10, 2026Contributors : Yue Wu ; Yiwen Hou ; Liang Wang ; Xiaoyu Zhu ; Cheng ZhanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo examine the impacts of recombinant human CD26/DPPIV protein and Sitagliptin on donor T-cell activation
- GSE286327 SOX4 regulates STAT6 to modulate MTHFD2 Expression and Impacts Drug Resistance in Hepatocellular Carcinoma January 10, 2026Contributors : Chia-Lung Tsai ; Ming-Chin Yu ; Chi-Neu TsaiSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensSOX4 overexpression in hepatocellular carcinoma (HCC) is linked to poor prognosis, modulating gene expression via epigenetic mechanisms. This study reveals SOX4 interacts with DNA demethylases to reduce STAT6 prom […]
- GSE164608 Post-transcriptional regulation of proliferation and quiescence (total_RNAseq) January 10, 2026Contributor : Holly HallSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensmRNA profiles of proliferating and quiescent human fibroblasts
- GSE315650 Spatial genome organization is associated with nematode programmed DNA elimination [Hi-C Parascaris univalens] January 10, 2026Contributors : James R Simmons ; Jianbin WangSeries Type : OtherOrganism : Parascaris univalensProgrammed DNA elimination (PDE) is a notable exception to genome integrity, characterized by significant DNA loss during development. In many nematodes, PDE is initiated by DNA double-strand breaks (DSBs), which lead to chromosome fragmentation and subsequent DNA […]
- GSE223337 Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double strand break repair and augments efficacy of temozolomide in glioblastoma II January 10, 2026Contributors : Salvador Alejo ; Yidong Chen ; Gangadhara R SareddySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPatient-derived primary GSCs were established from discarded specimens obtained from glioblastoma (GBM) patients undergoing surgery at UT Health San Antonio. We examined global transcriptional changes by RNA […]
- GSE178652 Post-transcriptional regulation of proliferation and quiescence January 10, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE314711 Sensory nerve-derived CGRP controls osteoclastogenesis by limiting macrophage bioenergetics in bone repair January 10, 2026Contributors : Jiaying Liu ; Ting Zhang ; Lili Li ; Kevin J DudleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculus ; Rattus norvegicusBone healing is a tightly orchestrated, multiphase process that requires coordinated interactions between immune cells and skeletal cells. Sensory nerves act as intrinsic effectors of the […]
- GSE313297 The hedgehog co-receptors cdon and boc function synergistically to regulate zebrafish craniofacial development January 10, 2026Contributors : Ryan Nickens ; Sophia Guitar ; Bryan Zepeda ; Julaine Roffers-Agarwal ; Kristin B. Artinger ; Ezra LencerSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioCraniofacial development is a complex developmental process that involves formation of the skeleton, muscle, and tendons. Defects in craniofacial developm […]
- GSE315564 Comprehensive multi-omics analyses elucidate the mechanism of male sexual dysfunction induced by chronic prostatitis/chronic pelvic pain syndrome in the experimental autoimmune prostatitis rat model January 10, 2026Contributor : Jiaochen LuanSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a condition characterized by persistent pain in the genitourinary tract. Men with CP/CPPS are significantly more susceptible to sexual dysfunction compared to the general populati […]
- GSE315275 Effect of FADS2 overexpression on gene expression of adipose stem cells January 10, 2026Contributors : Sen Ren ; Yu YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn the current investigation, an RNA-seq analysis was conducted to examine the differentially expressed genes in aged ASCs (O-ASCs) following the overexpression of FADS2. The analysis revealed that 84 genes were significantly upregulated, whi […]
- GSE315581 Wnt/β-catenin signaling restrains developmental beige adipocyte thermogenesis and its inhibition imprints long-term energy expenditure_Inguinal white adipose tissue (iWAT) from 4-week-old male mice January 10, 2026Contributor : Ganran XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBeige adipocytes that emerge during the peri-weaning period support sympathetic nervous system (SNS)-independent thermogenesis, yet the mechanisms governing this spontaneous beiging remain unclear.
- GSE315582 Wnt/β-catenin signaling restrains developmental beige adipocyte thermogenesis and its inhibition imprints long-term energy expenditure_Inguinal white adipose tissue from 4- and 8-week-old male mice January 10, 2026Contributor : Ganran XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBeige adipocytes that emerge during the peri-weaning period support sympathetic nervous system (SNS)-independent thermogenesis, yet the mechanisms governing this spontaneous beiging remain unclear.
- GSE315583 Wnt/β-catenin signaling restrains developmental beige adipocyte thermogenesis and its inhibition imprints long-term energy expenditure_Primary adipocytes differentiated in vitro, 4- and 8-week-old male mice January 10, 2026Contributor : Ganran XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBeige adipocytes that emerge during the peri-weaning period support sympathetic nervous system (SNS)-independent thermogenesis, yet the mechanisms governing this spontaneous beiging remain unclear.
- GSE278068 Nanobody-tethered transposition for dual profiling of chromatin accessibility and DNA methylation January 10, 2026Contributors : Jizhou Liu ; Guorun Tang ; Ziang Lu ; Zhiying Wang ; Yelin Lan ; Guanzheng Luo ; Xiaocheng Weng ; Yafen Wang ; Xiang Zhou ; Jindi ZhouSeries Type : Methylation profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus musculusDNA methylation and histone modifications are critical epigenetic regulators that orchestrate gene e […]