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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE236762 Single nucleus transcriptomic analysis of osimertinib-induced cardiac dysfunction in the mouse heart January 9, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed single nuclei RNA sequencing (snRNA-seq) analysis of mouse left ventricular tissues to investigate transcriptomic changes caused by osimertinib treatment.
- GSE306783 EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity January 9, 2026Contributors : Jeffrey Granat ; Sanxiong Liu ; Danny ReinbergSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe Polycomb repressive complex 2 (PRC2) establishes transcriptionally silent chromatin by catalyzing histone H3 lysine 27 trimethylation (H3K27me3). Although cofactors such as MTF2 and JARID2 are k […]
- GSE280480 Gene expression profiling reveals two overarching types of anaplastic large cell lymphoma with distinct targetable biology: an LLMPP study January 9, 2026Contributors : Andrew Feldman ; Surendra DasariSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnaplastic large cell lymphomas (ALCLs) are CD30+ T-cell lymphomas that share pathologic features but differ in presentation, outcome, and genetics. Current classification incorporates clinical presentation and ALK status, but […]
- GSE270817 Regulation of the type I interferon response by chromatin organization (RNA-seq of HoxB8-FL pDC activation) January 9, 2026Contributors : N Adams ; I Tiniakou ; E Esteva ; A Khodadadi-Jamayran ; B ReizisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAntiviral type I interferons (IFN-I) including IFN-β and multiple subtypes of IFN-α are encoded within a single locus. Whereas most cell types produce primarily IFN-β, plasmacytoid dendritic ce […]
- GSE298094 EZH2 PROTACs are unable to abolish EZH2 activator function but inhibit certain prostate cancer by rapid senescence induction January 9, 2026Contributors : Wanqing Xie ; Qi Chu ; Xiaodong Lu ; Jonathan C. Zhao ; Jindan YuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEnhancer of Zeste Homolog 2 (EZH2) is the enzymatic subunit of the Polycomb Repressive Complex 2 (PRC2) that catalyzes H3K27 methylation for epigenetic silencing. EZH2 up-regulation or mutation […]
- GSE292101 Silencing mitochondrial gene expression in living cells January 9, 2026Contributors : Luis Daniel Cruz-Zaragoza ; Drishan Dahal ; Mats Koschel ; Angela Boshnakovska ; Aiturgan Zheenbekova ; Mehmet Yilmaz ; Marcel Morgenstern ; Jan-Niklas Dohrke ; Julian Bender ; Anusha Valpadashi ; Kristine A Henningfeld ; Silke Oeljeklaus ; Laura S Kremer ; Mirjam Breuer ; Oliver Urbach ; Michael Lidschreiber ; Stefan Jakobs ; Bettina Warschei […]
- GSE315686 Heterogeneity and plasticity of the naive CD4+ T cell compartment January 9, 2026Contributors : Alia Sajani ; Evelien Schaafsma ; Walburga Croteau ; Mohamed ElTanbouly ; Elizabeth C Nowak ; Chao Cheng ; Christopher M Burns ; Mary Jo Turk ; Randolph J Noelle ; Louise J LinesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhile naive CD4+ T cells have historically been considered a homogenous populati […]
- GSE300601 Single-cell RNA-sequenceing analysis of mouse intestinal organoids cultured in Matriel or type I collagen January 9, 2026Contributors : Sakura Kirino ; Kensuke Miyake ; Fumiya Uefune ; Shiro YuiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntestinal epithelial regeneration depends on cellular plasticity under inflammatory conditions. Two major forms of plasticity have been described: spatial plasticity, in which mature cells dedifferen […]
- GSE315892 RNA-binding proteins Zfp36l1 and Zfp36l2 protect against premature thymic involution. January 9, 2026Contributors : Jianxun Han ; Vinothkumar Rajan ; Juan Carlos Zúñiga-PflückerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe thymus is a primary lymphoid organ that undergoes progressive age-associated involution, leading to reduced T cell output and impaired adaptive immunity. In this study, we employed scRNA-Seq as […]
- GSE315877 Metabolic surgery mitigates early kidney injury in obese youth with diabetes by suppressing mTORC1/JAK–STAT signaling January 9, 2026Contributors : Phillip J McCown ; Rajasree Menon ; Abhijit S Naik ; Fadhl Alakwaa ; Matthias Kretzler ; Petter BjornstadSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Youth with type 2 diabetes (T2D) and severe obesity face high risk of diabetic kidney disease, which metabolic bariatric surgery (MBS) can mit […]
- GSE315972 TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons in iPSC derived neurons and ALS/FTD patient tissues [brain isoseq] January 9, 2026Contributors : Isobel Bolger ; Regina Shaw ; Oliver H Tam ; Claudio Roque ; Chris Jackson ; Hemali Phatnani ; Molly Gale HammellSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTDP-43 is an RNA and DNA binding protein that plays major roles in regulating RNA processing. In particular, TDP-43 dysfunction leads to the accu […]
- GSE315982 DAXX governs the silencing of LINE1 during spermatogenesis in mice [RNA-seq] January 9, 2026Contributors : Zejia Li ; Chaoyang Xiong ; Jin Shen ; Chen Tan ; Dupeng Ma ; Jun Chen ; Rong Liu ; Qi Sun ; Weihao Gong ; Wenming Yuan ; Mengya Huang ; Li Huang ; Yueqiu Tan ; Guohong Li ; Mengcheng LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe suppression of transposable elements in germline is critical for sa […]
- GSE315983 LONP-1 deficiency causes dysregulated protein synthesis within mitochondria that is restored by mitoribosomal mutations January 9, 2026Contributors : Levi D Ali ; Avijit Mallick ; Cole M HaynesSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansMitochondrial homeostasis is maintained by multiple molecular chaperones and proteases located within the organelle. The mitochondrial matrix-localized protease LONP-1 degrades oxidatively damaged or misfo […]
- GSE302146 scRNA-seq of induced pluripotent stem cell derived decidual natural killer cells January 9, 2026Contributors : Virginia C Cheung ; Mana ParastSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDecidual natural killer (dNK) cells are the most abundant immune cells at the maternal-placental interface in early gestation. The exploration of dNK cell heterogeneity and function is currently an active area of research, part […]
- GSE315610 Heterogeneity and plasticity of the naive CD4+ T cell compartment [mouse CITEseq] January 9, 2026Contributors : Alia Sajani ; Evelien Schaafsma ; Walburga Croteau ; Mohamed ElTanbouly ; Elizabeth C Nowak ; Chao Cheng ; Christopher M Burns ; Mary Jo Turk ; Randolph J Noelle ; Louise J LinesSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWhile naive CD4+ T cells have historically been considered a homogenous […]