NCBI Insights

NCBI Insights

• Coming Soon: Updated PubMed Central (PMC) E-Utilities January 6, 2026
  PubMed Central (PMC) is moving to an updated version of the E-utilities API in early February 2026. This version of E-utilities will use the same technology as the updated PMC website search, which was released in September 2025. This change means search results returned by the updated ESearch E-utility will now match those of the … Continue reading Coming S […]
  NCBI Staff
• Top Posts of 2025: A Look at the NCBI Insights Blog January 5, 2026
  As we begin a new year, let’s look back at the top viewed NCBI Insights Blog posts of 2025!    In case you missed any of these, check them out: Learn more  The NCBI Insights Blog is intended to help you better understand NCBI and our resources, explore issues of scientific interest that drive our resource … Continue reading Top Posts of 2025: A Look at the N […]
  NCBI Staff
• GenBank Release 269.0 December 22, 2025
  GenBank release 269.0 (12/16/2025) is now available on the NCBI FTP site. This release has 49.73 trillion bases and 6.03 billion records. The current release has:  259,677,058 traditional records containing 6,651,459,875,408 base pairs of sequence data 4,540,323,299 WGS records containing 42,125,323,988,215 base pairs of sequence data 1,033,885,396 bulk-orie […]
  NCBI Staff
• Upcoming Change in My Bibliography September 8, 2025
  Use of earliest publication date for determining NIH Public Access compliance As shared in the July National Center for Biotechnology Information (NCBI) Insights post, NCBI at the National Library of Medicine (NLM) is making ongoing improvements to several offerings to support implementation of the 2024 NIH Public Access Policy. Effective October 1, 2025, My […]
  NCBI Staff
• An Updated Bacterial and Archaeal Reference Genome Collection is Available! September 2, 2025
  Download the updated bacterial and archaeal reference genome collection! We built this collection of 22,082 genomes by selecting the “best” genome assembly for each species among the 440,000+ prokaryotic genomes in RefSeq.  What’s new?  28 species are represented in this collection for the first time  228 species are represented by a better assembly  Six spe […]
  NCBI Staff
• GenBank Release 268.0 is Available! August 26, 2025
  GenBank release 268.0 (8/18/2025) is now available on the NCBI FTP site. This release has 47.01 trillion bases and 5.90 billion records. The current release has:  258,320,620 traditional records containing 5,676,067,778,413 base pairs of sequence data 4,441,331,387 WGS records containing 40,390,433,406,298 base pairs of sequence data 1,010,159,820 bulk-orien […]
  NCBI Staff
• Upcoming Changes to GenBank Project Lists and Symlinks August 20, 2025
  The volume of GenBank WGS, TSA, and TLS data sets is large and continues to grow rapidly. To help you identify and retrieve newly released data, we began providing symlinks and project list files in the Index of /genbank/daily-nc area approximately 12 years ago.  What’s new?  As the number of projects and files increases, the … Continue reading Upcoming Chan […]
  NCBI Staff
• PubMed Central (PMC) Beta Search to Replace Current Search August 19, 2025
  Coming the week of September 7th   The new PubMed Central (PMC) Beta search will replace the current PMC search the week of September 7, 2025.   As previously announced, the National Library of Medicine (NLM) National Center for Biotechnology Information (NCBI) is working on an update to PMC full-text search functionality and user experience. To … Continue r […]
  NCBI Staff
• Now Live: Improved Representation of Functional Data in ClinVar! August 18, 2025
  ClinVar is pleased to announce that our improved representation of functional data is live on the website, in file submissions, and in downloadable XML files. The following documentation is provided to facilitate future submissions and downloads: Instructions for submitting functional data in our Excel submission templates Updated submission templates Update […]
  NCBI Staff
• Now Available! NCBI Hidden Markov Models (HMM) Release 18.0 August 14, 2025
  Download release 18.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP). Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package.  What’s new?  Release 18.0 contains:  18,057 HMMs maintained by NCBI  631 new HMMs sinc […]
  NCBI Staff