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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE287510 Gene expression analysis of HepG2 cells overexpressing TAF2 December 12, 2025Contributors : Devanand Sarkar ; Mikhail DozmorovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTaf2 is a transcription co-factor and a member of TFIID complex. To better understand gene regulation of Taf2 we generated stable clones of HepG2 cells overexpressing either eGFP or TAF2-V5. The analysis shows that overexpre […]
- GSE287188 Effects of active-state RAS inhibition on the colorectal cancer cell transcriptome December 12, 2025Contributors : Oleksandra Aust ; Alexandra Trinks ; Viola Hollek ; Nils Blüthgen ; Markus MorkelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere, we identified and categorized mechanisms of resistance to broad-spectrum active-state RAS inhibition in colorectal cancer cell lines. Emerging resistant cell populations a […]
- GSE295225 Transcriptomic changes in human SCC-25 Parental and RARG knockout cells in response to 6h and 48h treatments with RARγ agonists CD1530 or all-trans retinoic acid (RA). December 12, 2025Contributors : Helen R Hoxie ; Xiao-Han Tang ; Lorraine J GudasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVitamin A (retinol) metabolism and signaling through nuclear retinoic acid receptors (RARs α,β,γ) regulate embryonic development, immune functions, and cell differentiation in most cell types. RAR gamma (RARγ) […]
- GSE293632 The hegemonic EWSR1::ETS oncogene overrules core regulatory circuitry mechanisms in Ewing sarcoma. December 12, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE220752 Transcriptome of the liver tissue from Hyal1-knock out mice December 12, 2025Contributors : Xi Chen ; Michelle Dias ; Hari Yalamanchili ; Yi ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHyaluronidase-1 (Hyal1) is a lysosomal hyaluronidase that intracellularly hydrolyzes hyaluronan. The analysis of Hyal1's roles in hepatic gluconeogenesis from standard and obese conditions benefits fro […]
- GSE203312 The role of Yin Yang 1 in mouse KMWT1 glioma cells December 12, 2025Contributors : Karli Mockenhaupt ; Alexandra Gonsievski ; Mikhail Dozmorov ; Tomasz KordulaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe effects s of YY1 were evaluated on proliferation, migration, and gene expression of KMWT1 mouse glioma cells.
- GSE312934 Mycobacterial Metallophosphatase MmpE Functions as a Nucleomodulin to Regulate Host Gene Expression and Promote Intracellular Survival December 12, 2025Contributors : Chen Liu ; Baojie Duan ; Qiang Jiang ; Yifan Wang ; Yingyu Chen ; Lei Zhang ; Aizhen GuoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNucleomodulins are bacterial effectors that target host cell nuclei and play crucial roles as virulence factors in mycobacterial pathogenesis. Mycobacterium […]
- GSE271245 Airway epithelial hyperactivation of JAK-STAT signaling impairs type-III IFN responses during RSV infection in Down Syndrome [Bulk RNA-seq] December 12, 2025Contributors : Elizabeth Chorvinsky ; Surajit Bhattacharya ; Betelehem Solomon Bera ; Allison Welham ; Claire M Lawlor ; Diego Preciado ; Jose L Gomez ; Maria J Gutierrez ; Hiroki Morizono ; Jyoti Jaiswal ; Gustavo NinoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTrisomy 21 (TS21), commonly known as Down syndrome (DS […]
- GSE313376 Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells [ATAC-seq] December 12, 2025Contributors : Julian Pulecio ; Danwei HuangfuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIt remains unclear how ESCs rapidly establish enhancer regulatory elements to activate lineage-specific genes at the earliest differentiation stages. Previous studies suggest that some tissue-specific enhancers ar […]
- GSE312946 Metabolic adaptation of stromal cells to fatty acid drives metastasis of oral squamous cell carcinoma December 12, 2025Contributors : Yiling Duan ; Yitong Li ; Yufei Wu ; Rui Li ; Xiao Yang ; Hui Zhao ; Zhengjun ShangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMetabolic adaptation enables cancer cell survival under nutrient stress, but how stromal cells in tumor microenvironment (TME) withstand similar metabolic change […]
- GSE313377 HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of Irgm1 December 12, 2025Contributors : Morgan J Chapman ; Jessie B Huskey ; Kaitlyn S Armijo ; Jaylen T Spellman-Reliford ; Aja K Coleman ; Cory J Mabry ; Stacy Hahn ; Robert O Watson ; Kristin L PatrickSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlternative splicing (AS) has been implicated in host responses to diverse pathogens, but our […]
- GSE313379 Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells [ChIP-Seq 2] December 12, 2025Contributors : Julian Pulecio ; Danwei HuangfuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIt remains unclear how ESCs rapidly establish enhancer regulatory elements to activate lineage-specific genes at the earliest differentiation stages. Previous studies suggest that some tissue-specific enhancers ar […]
- GSE313499 Identification of Novel Regulators of LINE-1 Expression via CRISPR/Cas9 Screening December 12, 2025Contributors : Ozgur Oksuz ; Chong Chu ; Cedric Arisdakessian ; Liyang Diao ; Dennis Zaller ; Kimberly K Long ; Heike Keilhack ; Sarah KnutsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Long Interspersed Nuclear Elements-1 (LINE-1, L1) are transposable elements that make up roughly 17% of the human genome […]
- GSE285564 Single-cell transcriptome comparison of myeloid cells’ in the retina in response to transplantation of human stem-cell derived neurons and to ocular damage reveals the reversibility of the microglia activation. December 12, 2025Contributors : Emil Kriukov ; Anthony Mukwaya ; Milica Margeta ; Petr BaranovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusRetinal ganglion cells (RGCs) play a critical role in the transmission of visual signals from the retina to the brain required for proper vision. The optic neuropathies, including g […]
- GSE312855 Transcriptomic profiling of brown adipose tissue in high-fat diet-induced obese mice following Pu-erh tea extract intervention December 12, 2025Contributors : Jiang Xiujuan ; Zeng LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Obesity driven by high-fat diet (HFD) is a global public health concern, and Pu-erh tea extract (PTE) exhibits anti-obesity potential, but its regulatory mechanism on brown adipose tissue (BAT) metabolism remains unclear […]