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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE290907 ZDHHC12 palmitoylates HDAC8 and promotes the development of hepatocellular carcinoma associated with a diet high in saturated fatty acids December 3, 2025Contributors : Xin Jin ; Yvlong HongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExcessive intake of saturated fatty acids (SFAs), which are prevalent in diets high in fried foods and red meat, poses a significant threat for hepatocellular carcinoma (HCC). Herein, we found via Mendelian randomization (MR) analysis th […]
- GSE289190 Unraveling the Molecular Mechanisms of Total Fertilization Failure: Insights into Transcriptional Dysregulation December 3, 2025Contributors : Manar Ata ; Fadi Choucair ; Mohamed Nadhir Djekidel ; Maria Esteves ; Fatima Al Ali ; Shoaib Nawaz ; Lina El Taha ; Oleksandr Soloviov ; Abbirami Sathappan ; Elbay Aliyev ; Khalid Fakhro ; Johnny Awwad ; Matteo A AvellaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Fertilization involves inter […]
- GSE242102 Transcription Factor 4 Maintains Endothelial Cell Identity by Inhibiting Endothelial to Mesenchymal Transition December 3, 2025Contributors : Min Chen ; Jie LvSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this study is to understand the role of TCF4 and its underlying mechanism in safeguarding the endothelial identity. Methods: In this study, by integrating ChIP-Seq, DNase-Seq, RNA-Seq, single-cell RNA sequencing (scRNA-seq), and […]
- GSE294687 Müller glia-mediated protection of retinal ganglion cells from ethambutol-induced neurotoxicity through brain-derived neurotrophic factor December 3, 2025Contributors : Hui-Chen Cheng ; Yu-Hui Wong ; An-Guor Wang ; Shih-Wei Chen ; Yong-Lin Yang ; Hsien-Chia Juan ; Roxanne Hsiang-Chi Liou ; Jenn-Yah YuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEthambutol (EMB)-associated optic neuropathy is the most common toxic optic neuropathy and poses a significant visual threat […]
- GSE279320 Single cell RNA sequencing data of CD45+ colonic cells derived from wild-type and VISTA-KO mice after oral treatment of dextran sulfate sodium. December 3, 2025Contributor : Binfeng ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo evaluate VISTA's function upon immune response in colitic mice, colonic immune cells from wild-type and VISTA-KO mice with dextran sulfate sodium induced colitis were used for single cell RNA sequencing.
- GSE267091 Ageing-induced cell type-specific transcriptomic changes in the skin are associated with abnormal early healing responses to injury December 3, 2025Contributors : Gokce Oguz ; Christabel Dube ; Yasmin Ong Hui Bin ; Samydurai Sudhagar ; Shyam Prabhakar ; Matthew Ronshaugen ; Adaikalavan Ramasamy ; Lim C Yan ; Kimberly MaceSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe progression of wound healing is delayed in aged skin. Previous studies have demonstrated that […]
- GSE312135 High-resolution in vivo binding data show that TBP initiates transcription at TATA promoters with and without TFIID [ChIP-nexus] December 3, 2025Contributors : Sergio G-M Alcantara ; Simon Bourdareau ; Melanie Weilert ; Julia ZeitlingerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterThis study investigates how the general transcription factor TFIID binds to different core promoter types in vivo. We performed high-resolution ChIP-nexus fo […]
- GSE282363 Urinary Extrecellular Vesicles miRNA Expression in Patients with Gitelman Syndrome: The Role of Hsa-let-7d-3p December 3, 2025Contributors : Chih-Chien Sung ; Chao-Ting Chen ; Min-Hsiu Chen ; Shih-Hua Lin ; Hsin-Yi Chang ; Yi-Jwo Lo ; Kuan-Chieh Peng ; Che-Chung HuangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensGitelman syndrome (GS) is a hereditary renal disorder caused by SLC12A3 mutations, resulting in salt-wasting and electrolyte im […]
- GSE312238 Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity with CHANGE-seq-BE [Digenome-seq] December 3, 2025Contributors : Rachael K Wood ; Varun Katta ; Jacqueline Chyr ; Shengdar Tsai ; Yichao LiSeries Type : OtherOrganism : Homo sapiensTo compare the sensitivity of CHANGE-seq-BE to another leading off-target discovery method, we performed Digenome-seq on the same ABE and CBE targets and evaluated them with matching analysis parameters. Many low-frequency off-ta […]
- GSE312136 High-resolution in vivo binding data show that TBP initiates transcription at TATA promoters with and without TFIID [RNA-seq] December 3, 2025Contributors : Sergio G-M Alcantara ; Simon Bourdareau ; Melanie Weilert ; Julia ZeitlingerSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThis study investigates how the general transcription factor TFIID binds to different core promoter types in vivo. We performed high-resolution ChIP-nexus for all 14 subun […]
- GSE312272 KDM6B inhibition modulates monocyte activation and alleviates IMQ-psoriasis skin inflammation December 3, 2025Contributors : Aman Damara ; Najla Abassi ; Delia Mihoc ; Mahsa Nastaranpour ; Pauline Kraft ; Tina Sarkar ; Michael Delacher ; Federico Marini ; Fatemeh ShahnehSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory monocytes are increasingly recognized as key amplifiers of psoriasis, yet the epigenetic drivers of […]
- GSE312284 Transcriptomic Profiling of Wild-Type C. elegans Exhibiting High and Low Exopher Production December 3, 2025Contributors : Michał Turek ; Wojciech PokrzywaSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansWe performed RNA sequencing on age-synchronized wild-type C. elegans that produced either high numbers of exophers (>20 per animal) or low numbers of exophers (
- GSE312287 KMT5A-Mediated Methylation of IRF3 Promotes Tumor Progression through Immune Suppression December 3, 2025Contributor : Pengcheng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLysine methylation is a critical post-translational modification (PTM) involved in diverse physiological and pathological processes. Interferon regulatory factor 3 (IRF3) plays a pivotal role in antitumor immunity; however, the regulatory mechanis […]
- GSE288297 Coincident evolution and functional adaptation of the Caenorhabditis-restricted genes ivph-3 and gon-14 December 3, 2025Contributors : Nikita S Jhaveri ; Bhagwati P Gupta ; Helen M ChamberlinSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis briggsaePoorly conserved or taxonomically-restricted genes represent a sizable portion of most genomes. Many of these genes participate in essential processes and can contribute to evolutionary innov […]
- GSE312051 Transcriptome and phenotype-based epistasis analysis in Caenorhabditis elegans reveal daf-16/FoxO-dependent and independent effects of daf-2/InsR in L1 arrest and recovery December 3, 2025Contributors : Kinsey C Fisher ; Rojin Chitrakar ; Ryan BaughSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansReduced insulin/IGF signaling (IIS) in C. elegans increases starvation resistance in daf-16/FoxO-dependent fashion, but it is unclear whether the effects of reduced IIS are entirely dependent on daf-16/ […]