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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE269164 Single-cell analysis reveals the epigenetic remodeling and key effectors of non-cardiomyocytes during heart regeneration. November 7, 2025Contributors : Zihao Chen ; Yage Nie ; Liying HuangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe restricted regenerative potential of adult hearts poses a significant barrier to effective repair following injury. In contrast to numerous vertebrates, mammalian hearts exhibit only transient neonatal re […]
- GSE271647 Aerial root growth mechanism of Prunus subgenus Cerasus × Incisa 'Gotenba zakura' and its waterlogging tolerance November 7, 2025Contributor : Xiaoxuan FengSeries Type : Expression profiling by high throughput sequencingOrganism : Prunus incisaPrunus subgenus Ceresus is a renowned ornamental wooden plant for its landscape applications and economic value in gardens. However, waterlogging during the rainy season in some areas cause deaths and heavy losses. Fortunately, we have found tha […]
- GSE270486 Convergent evolution of scavenger cell development at vertebrate brain borders November 7, 2025Contributors : Andrea U Gaudi ; Michelle Meier ; Oguzhan F Baltaci ; Sayali Chowdhary ; Frank J Tulenko ; Stefanie Dudczig ; Sebastian-Alexander Stamatis ; Scott Paterson ; Hujun Yu ; Maria Cristina Rondon Galeano ; Elizabeth Mason ; Lee B Miles ; Robert J Bryson-Richardson ; Andrew J Pask ; Jana Vukovic ; Anne K Lagendijk ; Kelly A Smith ; Jan Kaslin ; Mich […]
- GSE281226 Small RNA-seq of exosomes derived from fetal (55d) skin epithelial cells of Inner Mongolia cashmere goats November 7, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Capra hircusSmall RNA-seq of exosomes derived from epithelial cells of skin tissue on the side of the body of Inner Mongolia cashmere goats at 55 days of fetal development
- GSE280802 Endogenous production of nitric oxide by iNOS in human cells restricts inflammatory activation and cholesterol/fatty acid biosynthesis November 7, 2025Contributors : Franklin F Tam ; Jenice M Dumlao ; Amy H Lee ; Jonathan C ChoySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNitric oxide (NO) is a bioactive gas that is known to control many physiological processes. In human parenchymal cells, the function of iNOS-derived NO is incompletely understood. Here, we used RN […]
- GSE281346 IL-17A stimulates erythropoiesis by tuning the Erythropoietin-feedback circuit November 7, 2025Contributors : Qiu Chang Wu ; Aishwarya Swaminathan ; Ashley Winward ; Logan Lalonde ; Yung Hwang ; Noah Littman ; Merav Socolovsky ; Allon M KleinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFeedback control of erythropoiesis exemplifies conflicting goals in tissue homeostasis: maintaining fast reactivity to stress […]
- GSE281321 Alteration of Autophagy and Glial Activity in Nilotinib-Treated Huntington’s Disease Patients November 7, 2025Contributors : Max Stevenson ; Rency Varghese ; Charbel MoussaSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe explored the effects of a low dose of nilotinib (150 mg) on behavioral changes and motor symptoms in manifest HD patients and examined the effects of nilotinib on several brain mechanisms, including dopam […]
- GSE281450 LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment November 7, 2025Contributors : Jeffrey Reina ; Queralt Vallmajo-Martin ; Jia Ning ; Aubrey Michi ; Kay Yeung ; Geoffrey M Wahl ; Tony HunterSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTriple-negative breast cancer (TNBC) is a highly aggressive and metastatic form of breast cancer that lacks an effective targeted therapy. To identif […]
- GSE285294 Cannabis Use and Cannabidiol Modulate HIV-Induced Alterations in TREM2 Expression: Implications for Age-Related Neuropathogenesis November 7, 2025Contributors : Jerel A Fields ; Bryant AvalosSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe study investigates the modulation of TREM2 and related gene expression in HIV- and HIV+ individuals with varying cannabis use patterns. RNA-seq data were obtained from monocyte-derived macrophages exposed to CBD, IL1B, and C […]
- GSE294161 PLAMseq enables the simultaneous proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single workflow. November 7, 2025Contributors : Lourdes González-Vinceiro ; Carmen Espejo-Serrano ; María Eugenia Soler-Oliva ; María Luisa Mateos-Martín ; Daniel Rico ; Cristina González-Aguilera ; Román González-PrietoSeries Type : OtherOrganism : Homo sapiensChromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the ge […]
- GSE297594 MeCP2 regulates telencephalic development in human cerebral organoids November 7, 2025Contributors : Miguel F Tenreiro ; Alysson R MuotriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman cerebral organoids and telencephalic assembloids derived from iPSC lines: isogenic control and harboring MeCP2 variants associated with Rett Syndrome.
- GSE302718 Highly functional prolonged GC-TFH responses are associated with enhanced neutralizing antibody development November 7, 2025Contributors : Ester Marina-Zarate ; Shane CrottySeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaT follicular helper (TFH) cells are pivotal in generating high-affinity antibodies by supporting B cell survival, proliferation, affinity maturation, and differentiation into memory B cells and plasma cells. Here, we chara […]