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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE217296 RNA Binding Patterns of Ischemic Heart Failure Prognosis Indicator Eukaryotic Translation Initiation Factor 3m Reveal its Unique Role in Regulation of Nitrative Damage after Myocardial Ischemia-Reperfusion November 4, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Rattus norvegicusThis SuperSeries is composed of the SubSeries listed below.
- GSE248865 Glucocorticoid Receptor cistromic reprogramming by caloric restriction and corticosterone treatments. November 4, 2025Contributors : Konstantinos Makris ; Fania Feby Ramadhani ; Fabiana Quagliarini ; Nina H UhlenhautSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIn order to examine the impact of two separate corticosterone surges on liver physiology, we conducted genome-wide mapping of GR binding profiles at 6 pm (ZT12) […]
- GSE217623 Comparison of proteogenomic strategies for the generation of zebrafish fit-for-purpose protein databases November 4, 2025Contributors : Charlotte Macron ; James Holzwarth ; Corentin Beaumal ; Matthieu Porchet ; Jens Stolte ; Joy Richard ; Philipp Gut ; Sylviane Metairon ; Patrick Descombes ; Michael Affolter ; Loïc DayonSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Danio rerioHigh-quality protein databases (DBs) are essential for optimal an […]
- GSE281062 Methylation Array Signals are Predictive of Chronological Age Without Bisulfite Conversion November 4, 2025Contributors : Hunter L Porter ; Victor A Ansere ; Ram Babu Undi ; Walker Hoolehan ; Cory B Giles ; Chase A Brown ; David Stanford ; Mark M Huycke ; Willard M Freeman ; Jonathan D WrenSeries Type : Methylation profiling by arrayOrganism : Mus musculusDNA methylation data has been used to make “epigenetic clocks” which attempt to measure chronological and bio […]
- GSE249285 Ex vivo lung-organoid model for aberrant basaloid cell induction and activation November 4, 2025Contributors : Bin Wu ; Shigeyuki Shichino ; Satoshi Ueha ; Rina Matsukiyo ; Tatsuro Ogawa ; Kouji MatsushimaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung epithelial cell injury contributes to various lung diseases, impacting lung function and overall human health. Bleomycin (BLM)-induced murine models of pulmona […]
- GSE217257 Glucose metabolism influences the adaptive response of osteocytes to mechanical stimuli via CCN1 November 4, 2025Contributor : Mari SatoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBone loss is a diabetic-related complication. Chronic hyperglycemia affects bone quality, quantity and function1. Recently, reduced bone response to mechanical loading in diabetic mice have been reported2. However, it remains unclear whether hypergly […]
- GSE306285 Disparate Leukemia Mutations Converge on Nuclear Phase-Separated Condensates November 4, 2025Contributors : Gandhar K Datar ; Elmira Khabusheva ; Archish Anand ; Joshua Beale ; Marwa Sadek ; Chun-Wei Chen ; Evdokiia Potolitsyna ; Nayara Alcantara-Contessoto ; Guangyuan Liu ; Josephine De La Fuente ; Christina Dollinger ; Anna Guzman ; Alejandra Martell ; Katharina Wohlan ; Abhishek Maiti ; Nicholas J Short ; S. Stephen Yi ; Vibeke Andresen ; Bjørn T […]
- GSE297939 Charting the Multi-Level Molecular Response to Palbociclib in ER-Positive Breast Cancer November 4, 2025Contributors : Daniel Dominguez ; Michael J EmanueleSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe addition of CDK4/6 inhibitors to endocrine therapy has significantly improved outcomes in HR+/HER2- breast cancer. However, variable patient responses […]
- GSE294466 Xenium spatial transcriptomics of human carotid artery plaques November 4, 2025Contributors : Lars Maegdefessel ; Daniel Garger ; Jessica PauliSeries Type : OtherOrganism : Homo sapiensWe performed Xenium single cell transcriptomics on 4 plaques with matched controls (8 samples in total) and 8 additional plaques. A total of 16 samples was sequenced with two panels each.
- GSE305251 Lactyl-HDAC1-Mediated Epigenetic Gating of Angiogenic Transcription via Metabolic Reprogramming [RNA-seq] November 4, 2025Contributors : Chunbo Zhang ; Jianing ZhongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWhile angiogenesis serves as a cornerstone of embryogenesis and a defining feature of pathological progression, a critical gap persists in understanding how metabolic signaling precisely converges with nuclear reprogramming to ign […]
- GSE298149 The outcomes of caloric restriction are driven by enhanced glucocorticoid rhythms. November 4, 2025Contributors : Konstantinos Makris ; Ioannis K Deligiannis ; Liwei Zhang ; Fania Feby Ramadhani ; Celia P Martinez-Jimenez ; Fabiana Quagliarini ; Nina Henriette UhlenhautSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusCaloric restriction extends lifespa […]
- GSE305252 Lactyl-HDAC1-Mediated Epigenetic Gating of Angiogenic Transcription via Metabolic Reprogramming [ChIP-seq] November 4, 2025Contributors : Chunbo Zhang ; Jianing ZhongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWhile angiogenesis serves as a cornerstone of embryogenesis and a defining feature of pathological progression, a critical gap persists in understanding how metabolic signaling precisely converges with nuclear reprog […]
- GSE305657 Chronic stress disrupts hepatic kynurenine pathway to subvert hepatic CD8+ T cell immunity and promote liver cancer November 4, 2025Contributor : Renhui SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic psychological stress is associated with liver disease mortality, yet the reasons are unclear. Here we describe a stress-responsive brain-liver regulatory circuit that impairs CD8+T cell immunity and promotes the progression of liver cancer. […]
- GSE305686 Single-cell transcriptomics reveals significant differences in the developmental stage and quantity of adipose progenitor cells between bovine intramuscular and subcutaneous fat November 4, 2025Contributors : Zhendong Tan ; Pengcheng Lyu ; Honglin JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusBackground: Intramuscular fat (IMF), the white adipose tissue deposited between skeletal muscle fibers, is a key determinant of beef quality due to its contribution to meat, flavor, juiciness and tenderness. However, […]
- GSE217293 RNA Binding Patterns of Ischemic Heart Failure Prognosis Indicator Eukaryotic Translation Initiation Factor 3m Reveal its Unique Role in Regulation of Nitrative Damage after Myocardial Ischemia-Reperfusion [RNA-Seq] November 4, 2025Contributors : Zilun Wei ; Yongchao Zhao ; Aijun Sun ; Junbo GeSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusRNA undergoes various modifications in a manner similar to DNA, thereby opening up the research field of epitranscriptomics. Regulators of mRNA modifications play a role in many molecular processes, biolog […]