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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE152864 RNAseq of mRNA from hepatic CD8 T cell populations after low dose and during high dose AdV infection November 3, 2025Contributors : Verena König ; Miriam Bosch ; Nina Kallin ; Sainitin Donakonda ; Rupert Oellinger ; Thomas Engleitner ; Percy A KnolleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe aimed at dissecting phenotype, functionality and regulation of antigen-specific hepatic CD8 T cells after low dose or during high dose in […]
- GSE140320 FUNCTIONAL AND TRANSCRIPTOMIC ANALYSIS OF EXTRACELLULAR VESICLES IDENTIFIES CALPROTECTIN AS A NEW PROGNOSTIC MARKER IN PERIPHERAL ARTERIAL DISEASE (PAD) November 3, 2025Contributors : Goren Saenz-Pipaon ; Patxi San Martín ; Núria Planell ; Alberto Maillo ; Susana Ravassa ; Amaia Vilas-Zornoza ; Esther Martínez-Aguilar ; José A Rodriguez ; Daniel Alameda ; David Lara-Astiaso ; Felipe Prosper ; José A Paramo ; Josune Orbe ; David Gomez-Cabrero ; Carmen RoncalSeries Type : Expression profiling by high throughput sequencingOrga […]
- GSE261266 TPO stimulation midulates gene expression of iKMT2A-MLLT3 HSPC November 3, 2025Contributors : Hugues-Etienne Chatel-Soulet ; Jürg Schwaller ; Athimed El TaherSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInvestigate the immediate impact of in vivo exposure to exogenous TPO on gene expression,
- GSE246906 Therapeutic selective targeting of MMP-12 in B lymphocyte for the treatment of severe allergic airway disease November 3, 2025Contributors : Xijie Zhang ; Xinyu Jia ; Min Jia ; Manni Zhu ; Zhengxia Wang ; Zhongqi Chen ; Ningfei Ji ; Mao Huang ; Mingshun ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInducible Bronchus-Associated Lymphoid Tissue (iBALTs), the tertiary immune organs in the lungs, have been implicated in various pulmonary d […]
- GSE275332 MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription (RNA-Seq) November 3, 2025Contributors : Jun Y Sonn ; Marta Iwanaszko ; Ali Shilatifard ; Huda Y ZoghbiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss-of-function mutations in methyl-CpG binding protein 2 (MECP2) cause the neurodevelopmental disorder, Rett syndrome (RTT). The molecular mechanisms underlying MeCP2 function remain poorly unde […]
- GSE275329 MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription (ChIP-Seq) November 3, 2025Contributors : Jun Y Sonn ; Marta Iwanaszko ; Huda Y Zoghbi ; Ali ShilatifardSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusLoss-of-function mutations in methyl-CpG binding protein 2 (MECP2) cause the neurodevelopmental disorder, Rett syndrome (RTT). The molecular mechanisms underlying MeCP2 function rema […]
- GSE281010 PRC1 Mediates the Transcriptional Repressive Function of POGZ in Neurodevelopmental Gene Regulation November 3, 2025Contributors : Jessenia Chavez ; Zhonghua Gao ; James StaffordSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPolycomb Repressive Complex 1 (PRC1) is a family of fundamental epigenetic regulators crucial for gene silencing and mammalian development. Elucidating the PRC1 composition and function in context- and stage-spe […]
- GSE275333 MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription November 3, 2025Contributors : Jun Y Sonn ; Marta Iwanaszko ; Ali Shilatifard ; Huda Y ZoghbiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE285919 Piezo1 deficiency induces transcriptomic changes in HSCs [RNA-seq] November 3, 2025Contributors : Xinjiang Lu ; Tongyao Shang ; Li Zhao ; Shibo YingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe found that haematopoietic cell-specific Piezo1 knockout (KO) inhibits HSC proliferation and myeloid differentiation. To identify the underlying mechanism, we analysed the gene expression profiles of long-t […]
- GSE281154 mRNA transcriptome sequencing of tumor cells, TRMs, MDMs, Monocytes and CD8+ T cells from tumor lungs of KrasLSL-G12D/+Lkb1fl/fl (KL), KrasLSL-G12D/+Lkb1fl/flGpx4m/m(KLG4) after Ad-cre injection and tamoxifen treatment November 3, 2025Contributors : Peng Wang ; Shengdan Zhang ; Xin Chen ; Dandan Lin ; Bo ZhongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe transcriptional profiling of tumor cells, TRMs, MDMs, Monocytes and CD8+ T cells from tumor lungs of KL and KLG4 mice
- GSE285920 Activation of Piezo1 induces heterogeneity in LSK cells leading to HSC proliferation and myelopoiesis [scRNA-seq] November 3, 2025Contributors : Xinjiang Lu ; Tongyao Shang ; Li Zhao ; Shibo YingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBone marrow haematopoietic stem cells (HSCs) are mobilised into blood under various stresses. Although they are exposed to shear stress during circulation, the role of mechanical stimulation in regulating HSC […]
- GSE294561 YTHDF3 Promotes the Translation of m6A-Enriched Mitosis-Associated Genes to Attenuate the Responsiveness to Neoadjuvant Chemotherapy in Esophageal Cancer [RIP-seq] November 3, 2025Contributors : Xiang Y Wang ; Ting wang ; Si M Zhao ; Zi G DongSeries Type : OtherOrganism : Homo sapiensNeoadjuvant chemotherapy (NACT) is a pivotal treatment strategy for esophageal cancer, significantly improving patient prognosis and 5-year survival rates. However, a substantial proportion of patients exhibit resistance to NACT and consequently fail to b […]
- GSE300606 MNX1 prevents somatostatin expression in human beta cells by repressing PERCC1 November 3, 2025Contributors : Farah Kobaisi ; Alicia Maugein ; Alexis Fouque ; Olivier Albagli-Curiel ; Philippe Ravassard ; Raphael ScharfmannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA highly specific mosaic transcriptional environment guides the fate of pancreatic progenitors during development and next maintains the identity […]
- GSE305309 Human Placenta–Derived Mesenchymal Stem Cells Attenuate Hippocampal Aging-Associated Transcriptomic Profiles in Aged Mice November 3, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground Intravenous human placenta–derived mesenchymal stem cells (hpMSCs) can improve tissue function through paracrine effects, but their impact on normal brain aging is not well defined. Methods Aged female mice (18–19 months) received three intravenous infusions of […]
- GSE305310 miRNA-Seq of Extracellular Vesicles from Human Placenta–Derived Mesenchymal Stem Cells November 3, 2025Series Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensExtracellular vesicles (EVs) released by human placenta–derived mesenchymal stem cells (hpMSCs) are thought to mediate paracrine effects. To characterize their small-RNA cargo, we isolated hpMSC-derived EVs (hpEVs) from conditioned media using size-exclusion chromatogr […]