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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE279839 IG_Sickle_ExRNA1 October 27, 2025Contributors : Ionita Ghiran ; Moua Yang ; Vivian TranSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusTo investigate changes in small RNA quantity in Sickle cell disease in mice versus non-diseased mice with or without carbon monoxide treatment.
- GSE279500 Fruit derived superoxide dismutase nanozyme for sepsis-induced acute lung injury therapy October 27, 2025Contributor : Zhongyao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAs a life-threatening infectious disease in clinics, sepsis is characterized by uncontrolled systemic inflammatory response and multi-organ damage due to the excessive production of reactive oxygen species (ROS). The lung is the most frequently aff […]
- GSE286919 Nutrient stress diverts RRN3 from rRNA transcription to alternative polyadenylation of autophagy mRNAs in ovarian cancer [PAR-CLIP] October 27, 2025Contributor : Jianying LvSeries Type : OtherOrganism : Homo sapiensStress-induced alternative processing of mRNA is emerging as an essential mechanism to drive almost every hallmark of cancer. Through a genome-wide screening based on an abnormal transcriptional readthrough event favoring the malignant progression of ovarian carcinoma (OC), we identified nove […]
- GSE286558 Nutrient stress diverts RRN3 from rRNA transcription to alternative polyadenylation of autophagy mRNAs in ovarian cancer October 27, 2025Contributor : Jianying LvSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensStress-induced alternative processing of mRNA is emerging as an essential mechanism to drive almost every hallmark of cancer. Through a genome-wide screening based on an abnormal transcriptional readthrough event favoring the malignan […]
- GSE309440 Probing the structure of the lncRNA DAMER and its interaction with ATF4 mRNA using SHAPE-MaP October 27, 2025Contributors : Tianyu Tao ; Yi Yang ; Xianming Feng ; Bangdong Liu ; Junchao Cai ; Mengfeng LiSeries Type : OtherOrganism : Homo sapiensThis experiment was conducted to obtain direct structural evidence for the base-pairing interaction between DAMER and ATF4 mRNA. In vitro transcribed RNAs (DAMER-WT, ATF4 mRNA, DAMER mutants) were folded either alone or toge […]
- GSE286920 Nutrient stress diverts RRN3 from rRNA transcription to alternative polyadenylation of autophagy mRNAs in ovarian cancer [CRISPR Screen] October 27, 2025Contributor : Jianying LvSeries Type : OtherOrganism : Homo sapiensStress-induced alternative processing of mRNA is emerging as an essential mechanism to drive almost every hallmark of cancer. Through a genome-wide screening based on an abnormal transcriptional readthrough event favoring the malignant progression of ovarian carcinoma (OC), we identified nove […]
- GSE293198 Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication [LD-OK-seq] October 27, 2025Series Type : OtherOrganism : Homo sapiensReplication origins in human cells form clusters ranging from tens to hundreds of kilobases called initiation zones (IZs), typically located in intergenic regions between active genes. On a larger megabase scale, chromosomes replicate in a temporally defined replication timing (RT) pattern, where euchromatic regions […]
- GSE216726 Gene expression profile at single cell level of Normal Colonic Epithelial Stem Cells (NCE-SC) October 27, 2025Contributors : Fumihiko Kakizaki ; Hiroyuki Miyoshi ; M M TaketoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNCE-SC are inferred as a homogeneous population cultured in the eL-WRN medium (Miyoshi H, Oncotarget 2018;9(31):21950-64.). We used single-cell RNA sequencing (scRNA-seq) to confirm the homogeneity of NCE-SCs. […]
- GSE295033 Transcriptional profiling of sensory cells of the murine gut and vagus nerve October 27, 2025Contributors : Robert J Lovelett ; Maja Engelstoft ; John Whang ; Maximilian G Lombardo ; Adrian Heilbut ; Shirly PintoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusSensory cells of the gut epithelium and vagus nerve are key regulators of various physiological processes including satiety and metabolism. In thi […]
- GSE293200 Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication [RNA-Seq] October 27, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensReplication origins in human cells form clusters ranging from tens to hundreds of kilobases called initiation zones (IZs), typically located in intergenic regions between active genes. On a larger megabase scale, chromosomes replicate in a temporally defined replication ti […]
- GSE306900 C44H9.4/HZL-1 AMPK mutant dauer transcriptome October 27, 2025Contributors : Rashid Sabih ; Roy RichardSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansC. elegans lacking AMPK do not exhibit reproductive defects during normal growth, but when passaged through dauer, exhibit germline hyperplasia and premature spermatogenesis, followed by complete sterility post-dauer (Narb […]
- GSE309436 Identification of ALKBH5-interacting RNAs in lung cancer cells by RNA immunoprecipitation sequencing (RIP-Seq) October 27, 2025Contributors : Tianyu Tao ; Yi Yang ; Xianming Feng ; Bangdong Liu ; Junchao Cai ; Mengfeng LiSeries Type : OtherOrganism : Homo sapiensThis experiment was performed to identify the RNAs, particularly lncRNAs, that bind to the m6A demethylase ALKBH5 under nutrient stress. Lysates from 95D cells cultured under glucose- or glutamine-deficient conditions were s […]
- GSE309437 Identification of DAMER-interacting RNAs by RNA-RNA pulldown assay and sequencing [RNA-Seq] October 27, 2025Contributors : Tianyu Tao ; Yi Yang ; Xianming Feng ; Bangdong Liu ; Junchao Cai ; Mengfeng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis experiment aimed to identify all transcripts that directly interact with the lncRNA DAMER. Full-length DAMER was transcribed in vitro and biotinylated at the 3' end. The […]
- GSE270723 Effect of single essential amino acids deprivation on drosophila melanogaster head transcriptome October 27, 2025Contributors : Gili Ezra-Nevo ; Silvia Henriques ; Daniel Münch ; Francisco A Patricia ; Celia Baltazar ; Ana-Paula Elias ; Bart Deplancke ; Carlos RibeiroSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterMaintaining sufficient levels of Amino acids (AAs) from the diet is essential for the organism to maintain […]
- GSE293196 Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication [IP-seq] October 27, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensReplication origins in human cells form clusters ranging from tens to hundreds of kilobases called initiation zones (IZs), typically located in intergenic regions between active genes. On a larger megabase scale, chromosomes replicate in a temporally defined […]