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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE279403 Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 October 22, 2025Contributors : Qiming Zhang ; Fangtao Chi ; Omer H YilmazSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA critical question in physiology is to understand how tissuesadaptand alter their composition in responsetodietary cues.The mammalian small intestine, avitaldigestive organ thatabsorbs nutrients, is maintainedby rap […]
- GSE282931 Chemotherapy-driven intestinal dysbiosis and microbial indole-3-propionic acid rewire bone marrow myelopoiesis to promote anti-metastatic immunity October 22, 2025Contributors : Ludivine Bersier ; Tatiana V Petrova ; Tania WyssSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe investigated how microbial derived product influence myeloid cell differentiation in vitro.
- GSE280123 Circadian Reprogramming by Timed Sodium Intake Reveals Transcriptional Pathways of Daily Salt Handling in the Colon. October 22, 2025Contributors : Takuto Torimitsu ; Kenichiro Kinouchi ; Kousha Changizi Ashtiani ; Sherif Abdelkarim ; Pierre Baldi ; Hiroshi ItohSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe circadian gene expression in peripheral tissue displays rhythmicity which is reprogrammed by feeding rhythms and dietary composition in mamm […]
- GSE289281 Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse Atherosclerosis October 22, 2025Contributors : Lauren E Fries ; Allen Chung ; Hyun K Chang ; Timothy L Yuan ; Robert C BauerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in the western world despite the success of lipid lowering therapies, highlighting […]
- GSE287952 Transcriptional profile of B16-OVA cells with PUM1 knockout October 22, 2025Contributors : Xue Zhang ; Chenchen Pan ; Shuo Song ; Yaqi Li ; Defen Zhou ; Hanwei Cui ; Jiangan XieSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPUM1 is a highly conserved RNA-binding protein that plays a key role in regulating mRNA stability. B16-OVA knockout PUM1 cell lines were constructed using CRISPR/CAS9 gene […]
- GSE261171 High-Resolution Single-Cell RNA Sequencing Uncovers Disparate Neutrophil Populations within Metastatic Cancer Lesions Linked to Progression Free Survival in Multiple Myeloma Patients October 22, 2025Contributors : Hillengass Jens ; Mohammadpour Hemn ; McCarthy Philip ; Samur MehmetSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUnderstanding the myeloid cell biology of the tumor microenvironment (TME) will allow discovery of novel strategies to disrupt the local immunosuppressive milieu and to develop effective imm […]
- GSE230171 SELEX-seq of AP1 homodimer October 22, 2025Contributors : Peilin Chen ; Jose M Muino ; Cezary Smaczniak ; Kerstin KaufmannSeries Type : OtherOrganism : synthetic constructThese datasets represent the results of a SELEX-seq experiment to identify the DNA binding specificity of Arabidopsis thaliana AP1-AP1 dimers
- GSE300712 RAS(ON) multi-selective inhibition drives anti-tumor immunity in preclinical models of NRAS-mutant melanoma October 22, 2025Contributors : Larissa A Da Costa Carvalho ; Nataliya T Shifrin ; Michael F Emmons ; Ximo Pechuan-Jorge ; Felix Mbuga ; Oscar Espinosa ; Christopher Chow ; Lillian Seu ; Manali S Phadke ; Olivia L Rose ; Aparna Hegde ; Nikhil I Khushalani ; Elsa Quintana ; Keiran SmalleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTa […]
- GSE299453 Perturbation of multi-molecular complexes in skeletal muscle induces protective proteases in the CNS that degrade pathogenic proteins October 22, 2025Contributors : Mamta Rai ; Helen Baddeley ; Chia-Lung Chuang ; Anna Platt ; Michelle Curley ; David Finkelstein ; Fabio DemontisSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterABSTRACT. Many cellular functions are ensured by the activity of multimolecular complexes and homeostatic mechanisms ensure their stoi […]
- GSE304356 Silencing of S100A11 Attenuates Murine Metabolic Dysfunction-associated Steatohepatitis October 22, 2025Contributors : P. Vineeth Daniel ; Gyanendra Puri ; Yixing Luo ; Naresh Golla ; Takahito Nishihara ; Hanna Erickson ; George Marek ; Davide Povero ; Amy Mauer ; Jun Liu ; Harmeet MalhiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusS100A11 is an alarmin known to be upregulated in MASH; however, its role in MASH pathophy […]
- GSE302225 Dermal fibroblast cultures recapitulate differences between deermice and mice in their responses to Toll-like receptor agonists October 22, 2025Contributors : Jonathan Duong ; Aqsa Motiwala ; William Hotz ; Landen Gozashti ; Anthony Long ; Alan BarbourSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculus ; Peromyscus leucopusThe white-footed deermouse Peromyscus leucopus is a primary reservoir for the agents of Lyme disease and other zoonoses in North America. These […]
- GSE306422 Contribution of macrophage subsets to scarless skin regeneration in Xenopus laevis frogs October 22, 2025Contributors : Christina Garvey Griffith ; Kelsey Hauser ; Bradley Abramson ; Katharine Jennings ; Elissa R Chapkin ; Elizabeth Jones ; Anju Duttargi ; Leon GrayferSeries Type : Expression profiling by high throughput sequencingOrganism : Xenopus laevisXenopus laevis juvenile frogs are uniquely capable of scarless skin regeneration, but the cellular and mole […]
- GSE307250 Gestational Feed Restriction Induces Differential Expression of Novel Long Non-Coding RNAs in Offspring Skeletal Muscle October 22, 2025Contributors : Maria Muniz ; Thais Costa ; Nicola Serão ; Mateus Gionbelli ; Marcio DuarteSeries Type : Expression profiling by high throughput sequencingOrganism : Capra hircusFetal programming via maternal nutrition during gestation plays a key role in shaping skeletal muscle development, directly affecting meat quality and production efficiency. This stud […]
- GSE307696 Epigenomic analysis of human advanced heart failure October 22, 2025Contributors : Esther Roselló-Lletí ; Estefanía TarazónSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThe goal of this study is to compare the epigenome of advanced heart failure patients (with idiopathic dilated cardiomyopathy) undergoing heart transplantation compared with healthy controls.
- GSE271980 Deletion of KLHDC3, an E3 ubiquitin ligase complex substrate receptor, leads to obesity in mice October 22, 2025Contributors : M F Smeets ; P A Buco ; Z Liang ; A M Chalk ; S Taylor ; A Gupte ; J E Heraud-Farlow ; C R WalkleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusProtein ubiquitination is a critical post-translational modification that regulates protein stability and cellular homeostasis. KLHDC3 is a substrate recognitio […]