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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE287952 Transcriptional profile of B16-OVA cells with PUM1 knockout October 22, 2025Contributors : Xue Zhang ; Chenchen Pan ; Shuo Song ; Yaqi Li ; Defen Zhou ; Hanwei Cui ; Jiangan XieSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPUM1 is a highly conserved RNA-binding protein that plays a key role in regulating mRNA stability. B16-OVA knockout PUM1 cell lines were constructed using CRISPR/CAS9 gene […]
- GSE237154 Monitoring the complexity and dynamics of mitochondrial translation October 22, 2025Contributors : Taisei Wakigawa ; Mari Mito ; Haruna Yamashiro ; Kotaro Tomuro ; Fan-Yan Wei ; Kazuhito Tomizawa ; Takeshi Chujo ; Asuteka Nagao ; Takeo Suzuki ; Yuichi Shichino ; Tsutomu Suzuki ; Shintaro IwasakiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus ; Mus musculusEukaryotes house the additional […]
- GSE309085 Methylome-driven regulation of miRNA expression and its relationship to cardiac dysfunction in idiopathic dilated cardiomyopathy October 22, 2025Contributors : Esther Roselló-Lletí ; Estefanía TarazónSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensIdiopathic dilated cardiomyopathy (iDCM) is a multifactorial disease with a complex pathogenesis involving diverse molecular mechanisms. Among these, epigenetic mechanisms, including both DNA methylation and microR […]
- GSE265817 Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing October 22, 2025Contributors : Mingxin Xu ; Zhao Li ; Masnsen Cherief ; Aaron W JamesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA central feature of bone injury is the sensation of pain, transmitted by nociceptive sensory nerves that innervate the skeleton. Indeed skeletal-innervating peripheral neurons are known to regulate skele […]
- GSE249206 Piezo1 balances the osteogenic-tenogenic plasticity of periosteal progenitor cells through the YAP pathway October 22, 2025Contributors : Weiguo Zou ; Lijun Wang ; Qian Ren ; Shuqin Chen ; Lixiang Lou ; Wenhui Xing ; Jun Sun ; Xuye Hu ; Miaomiao Wang ; Heng Feng ; Matthew B GreenblattSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe extremity tendons and bones are derived from limb bud mesenchyme, which eventually become cells of differen […]
- GSE280123 Circadian Reprogramming by Timed Sodium Intake Reveals Transcriptional Pathways of Daily Salt Handling in the Colon. October 22, 2025Contributors : Takuto Torimitsu ; Kenichiro Kinouchi ; Kousha Changizi Ashtiani ; Sherif Abdelkarim ; Pierre Baldi ; Hiroshi ItohSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe circadian gene expression in peripheral tissue displays rhythmicity which is reprogrammed by feeding rhythms and dietary composition in mamm […]
- GSE279403 Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 October 22, 2025Contributors : Qiming Zhang ; Fangtao Chi ; Omer H YilmazSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA critical question in physiology is to understand how tissuesadaptand alter their composition in responsetodietary cues.The mammalian small intestine, avitaldigestive organ thatabsorbs nutrients, is maintainedby rap […]
- GSE297649 umami experiment-Analysis of the effect of amino-acids and humic substances on the transcriptome of Arabidopsis October 22, 2025Contributors : Stéphanie Pateyron ; Christine Paysant-LeRoux ; Christian MeyerSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thaliana2022_13_qs_umami- umami experiment-Analysis of the effects of biostimulants (amino-acids and humic substances) on plants-Analysis of transcriptomic variations in Arabidopsis seedlings gro […]
- GSE297140 Metformin inhibits IFN-g-mediated activation of macrophages in necrobiotic xanthogranuloma October 22, 2025Contributors : Kerstin Becker ; Ahlem Aloui ; Muhammad Sajid Hussain ; Henning Klapproth ; Manuel Huerta Arana ; Mario FabriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study included lesional and non-lesional skin samples of patients diagnosed with NXG as well as control skin (non-involved, discarded skin obtai […]
- GSE300712 RAS(ON) multi-selective inhibition drives anti-tumor immunity in preclinical models of NRAS-mutant melanoma October 22, 2025Contributors : Larissa A Da Costa Carvalho ; Nataliya T Shifrin ; Michael F Emmons ; Ximo Pechuan-Jorge ; Felix Mbuga ; Oscar Espinosa ; Christopher Chow ; Lillian Seu ; Manali S Phadke ; Olivia L Rose ; Aparna Hegde ; Nikhil I Khushalani ; Elsa Quintana ; Keiran SmalleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTa […]
- GSE299453 Perturbation of multi-molecular complexes in skeletal muscle induces protective proteases in the CNS that degrade pathogenic proteins October 22, 2025Contributors : Mamta Rai ; Helen Baddeley ; Chia-Lung Chuang ; Anna Platt ; Michelle Curley ; David Finkelstein ; Fabio DemontisSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterABSTRACT. Many cellular functions are ensured by the activity of multimolecular complexes and homeostatic mechanisms ensure their stoi […]
- GSE304356 Silencing of S100A11 Attenuates Murine Metabolic Dysfunction-associated Steatohepatitis October 22, 2025Contributors : P. Vineeth Daniel ; Gyanendra Puri ; Yixing Luo ; Naresh Golla ; Takahito Nishihara ; Hanna Erickson ; George Marek ; Davide Povero ; Amy Mauer ; Jun Liu ; Harmeet MalhiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusS100A11 is an alarmin known to be upregulated in MASH; however, its role in MASH pathophy […]
- GSE307250 Gestational Feed Restriction Induces Differential Expression of Novel Long Non-Coding RNAs in Offspring Skeletal Muscle October 22, 2025Contributors : Maria Muniz ; Thais Costa ; Nicola Serão ; Mateus Gionbelli ; Marcio DuarteSeries Type : Expression profiling by high throughput sequencingOrganism : Capra hircusFetal programming via maternal nutrition during gestation plays a key role in shaping skeletal muscle development, directly affecting meat quality and production efficiency. This stud […]
- GSE307696 Epigenomic analysis of human advanced heart failure October 22, 2025Contributors : Esther Roselló-Lletí ; Estefanía TarazónSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThe goal of this study is to compare the epigenome of advanced heart failure patients (with idiopathic dilated cardiomyopathy) undergoing heart transplantation compared with healthy controls.
- GSE282931 Chemotherapy-driven intestinal dysbiosis and microbial indole-3-propionic acid rewire bone marrow myelopoiesis to promote anti-metastatic immunity October 22, 2025Contributors : Ludivine Bersier ; Tatiana V Petrova ; Tania WyssSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe investigated how microbial derived product influence myeloid cell differentiation in vitro.