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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE265808 Single-nucleus RNA/ATAC-seq in early-stage hypertrophic-cardiomyopathy models predicts SWI/SNF-activation in mutant-myocytes and allele-specific differences in fibroblasts October 20, 2025Contributors : Tilo Thottakara ; Arun Padmanabhan ; Talha Tanriverdi ; Tharika Thambidurai ; Jose A Diaz-RG ; Sanika R Amonkar ; Jeffrey E Olgin ; Carlin S Long ; M R AbrahamSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusHypertrophic cardiomyopathy (HCM) is associated with phenotypic variability. To gain insigh […]
- GSE277715 The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia October 20, 2025Contributors : Kentson Lam ; Yoon Joon Kim ; Robert SignerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOncogenic growth typically places great strain and dependence on protein homeostasis (proteostasis) pathways. This has made proteostasis pathways attractive therapeutic targets in cancer, but efforts to drug compone […]
- GSE274703 Smug1 DNA glycosylase modulates the perception of smell in mouse brain through downregulation of olfactory receptor genes October 20, 2025Contributors : Diana Bordin ; Yohan Lefol ; Garry Wong ; Nurye Tekin ; Junbai WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe SMUG1-DNA glycosylase is the primary enzyme responsible for excising 5-hydroxymethyluracil (5hmU) from genomic DNA. SMUG1 activity is high in the brain and is therefore proposed to be par […]
- GSE216151 Gene expression of ISG15-treated immortalized fibroblasts October 20, 2025Contributors : Ssu-Han Wang ; Yu-Lin Chen ; Ya-Wen ChenSeries Type : Expression profiling by arrayOrganism : Homo sapiensImmortalized fibroblasts (S1F and R2 cells) were tretaed with or without 300 ng/ml ISG15 for 2 days
- GSE308951 A platelet transcriptomic signature of thromboinflammation predicts cardiovascular risk October 20, 2025Contributors : Jeffrey S Berger ; Matthew Muller ; Antonia Beitzen-HeinekeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe CHOlesterol Reduction and Residual Risk in type 2 Diabetes (CHORD) study was a prospective study that investigated the effect of lipid lowering therapieis in participants with LDL-C >100 mg/dL […]
- GSE242275 Human oligodendrocyte progenitor cells mediate synapse elimination through TAM receptor activation October 20, 2025Contributors : Susmita Malwade ; Carl M Sellgren ; S SamudyataSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent work in animal models suggests that oligodendrocyte progenitor cells (OPCs) contribute to elimination of synapses in the developing brain. However, a mechanistic understanding of this process is still mis […]
- GSE216422 Thyroid Stimulating Hormone (TSH) Protects Against Osteoporosis through AMPK Signaling Pathway in Osteoclasts II October 20, 2025Contributors : Wenwen Zhang ; Yu Chen ; Yan Wang ; Yanman Zhou ; Honglin Guo ; Jin XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIt has been believed that osteoporosis associated with hyperthyroidism due to elevated thyroxine level. But patients with subclinical hyperthyroidism, decline in the level of thyroid stimu […]
- GSE302628 Evaluation of the pharmacological effects of oridonin on hepatic ischemia/reperfusion injury in vivo October 20, 2025Contributors : Qiyuan Yang ; Zhikun Zhan ; Hang Wang ; Siyu Chen ; Lingyan Liu ; Qiaoling WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe study aims to explore the protective effects of oridonin against hepatic ischemia–reperfusion injury (IRI) and its underlying mechanisms. Hepatic IRI is a significant clinical i […]
- GSE302320 C9orf72 hexanucleotide repeat expansions impair microglial response in models of ALS October 20, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE303703 SOX2 confers tumour permissiveness in a specific skin progenitor population October 20, 2025Contributor : Centeno Patricia PSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe skin’s continuous renewal relies on stem and progenitor cells, yet their differential susceptibility to oncogenic mutations in cutaneous squamous cell carcinoma (cSCC) remains poorly understood. Rapid cSCC development occurs in melanoma […]
- GSE303415 RNA Sequencing of Liver and Skeletal Muscle from WT and Heterozygous IGF-1R Mutant Mice October 20, 2025Contributors : Alexander Tyshkovskiy ; Ulalume Hernández-Arciga ; Alibek Moldakozhayev ; Vadim N Gladyshev ; Andrey A ParkhitkoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis dataset includes gene expression profiles from liver and skeletal muscle samples of young female and male C57BL/6J mice with heterozygous IGF […]
- GSE304073 Effects of attenuating astrocytic Ca2+ activity in the medial prefrontal cortex with iβARK on transcriptional profiles in 5xFAD mice (snRNA-seq) October 20, 2025Contributors : Zhan Zhang ; You Zuo ; Wei-Jye Lin ; Yamei TangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe injected adeno-associated viruses (AAV2/5) carrying an inhibitory peptide derived from β-adrenergic receptor kinase 1 (iβARK), tagged with mCherry for identification, into the medial prefrontal cortex (mPFC) […]
- GSE307170 tert-Butylhydroquinone (TBHQ) suppresses LPS- and Poly (I: C)- induced RAW 264.7 macrophage activation through reduced NF-κB/type 1 interferon and enhanced antioxidant-related pathways October 20, 2025Contributors : Alyssa M Whisel ; Charles D RiceSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe global demand for processed foods has increased reliance on synthetic phenolic antioxidants (SPAs), including tert-butylhydroquinone (TBHQ), a widely additive used to prevent lipid oxidation and extend shelf life. TBHQ is […]
- GSE308303 3D Bioprinted Endometrial Patch Enhances Regeneration and Fertility through Organotypic Endometrial Architecture October 20, 2025Contributors : Danbi Lee ; Tugce Sen ; Yu-Gyeong Lee ; Sun-Young Hwang ; Jae Yun Kim ; Jongmin Kim ; Jinah Jang ; Youn-Jung Kang ; Dong-Woo ChoSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusIntrauterine adhesions (IUA), a severe condition of endometrial injury, remains a major cause of female infertility due to th […]
- GSE246043 The budding yeast heterochromatic protein Sir3 modulates genome-wide gene expression through transient direct contacts with euchromatin October 20, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeThis SuperSeries is composed of the SubSeries listed below.