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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE206506 RNAseq analysis of skeletal muscle transcriptomes from wild type and MLL4SETf/fHSA-Cre mice October 18, 2025Contributors : Chenyun Ding ; Zhenji GanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEnhancers play central role in controlling gene expression in time and space. Primed enhancers are marked by histone H3 lysine 4 (H3K4) mono/di-methylation (H3K4me1/2). Mixed-lineage leukemia 4 (MLL4/KMT2D) is an evolutionarily conse […]
- GSE206416 RNAseq analysis of liver transcriptomes from wild-type and MLL4SETf/fHSA-Cre mice October 18, 2025Contributors : Chenyun Ding ; Zhenji GanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEvidence is emerging that skeletal muscle metabolic reprogramming could be a modifier of hepatic steatosis. Skeletal muscle-specific Mll4-knockout (MLL4SETf/fHSA-Cre) and wild-type (WT) littermates were placed on HFD (60% kcal from f […]
- GSE245689 STAMBP is required for long-term maintenance of neural progenitor cells derived from hESCs October 18, 2025Contributors : Jitian ZHANG ; Yanqi ZHANG ; Yancai LIU ; Xiao D SHUSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMutations in STAMBP have been well-established to cause congenital human microcephaly-capillary malformation (MIC-CAP) syndrome, a rare genetic disorder characterized by global developmental delay, severe m […]
- GSE216001 TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs October 18, 2025Contributors : Xin Jin ; Huaiyuan LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFor patients with advanced or metastatic Hepatocellular carcinoma (HCC) who are not suitable for surgical resection, systemic therapy has been considered to be the standard treatment. In recent years, a small subset of patients with u […]
- GSE245809 Irinotecan activates anti-tumor immunity in HCT116 tumor cells October 18, 2025Contributors : Xinghua Gao ; Yong Yang ; Yanting LinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTopoisomerase I (Top1) is a classical drug target for anticancer therapy, but its role in immune signaling in cancer cells remain unclear. Here, we aimed to explore the possible role and mechanism of Irinotecan (CPT-11) i […]
- GSE245737 Gene expression in whole seedlings (wild-type, dof1.7-KO) October 18, 2025Contributors : Yasuhito Sakuraba ; Shuichi YanagisawaSeries Type : Expression profiling by arrayOrganism : Arabidopsis thalianaTo examine differential effect of the mutation of Arabidopsis dof1.7 on the gene expressions, we performed microarray analysis using whole seedlings of wild-type and dof1.7-KO mutant.
- GSE246124 A noncanonical cytoplasmic role for BUB1 in restraining DNA damage-induced dsRNA accumulation and viral mimicry within stress granules [cytoplasmic RNA-seq] October 18, 2025Contributors : Mengjie Hu ; Dong Pan ; Meng Jiao ; Xuhui Bao ; Xinjian Liu ; Fang Li ; Chuan-Yuan LiSeries Type : Expression profiling by high throughput sequencingOrganism : HomoBUB1 is a nuclear serine/threonine protein kinase and a vital spindle assembly checkpoint (SAC) complex member responsible for proper chromosome segregation before mitosis. Here we […]
- GSE246123 A noncanonical cytoplasmic role for BUB1 in restraining DNA damage-induced dsRNA accumulation and viral mimicry within stress granules [RNA-seq] October 18, 2025Contributors : Mengjie Hu ; Dong Pan ; Meng Jiao ; Xuhui Bao ; Xinjian Liu ; Fang Li ; Chuan-Yuan LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBUB1 is a nuclear serine/threonine protein kinase and a vital spindle assembly checkpoint (SAC) complex member responsible for proper chromosome segregation before mitosis. […]
- GSE279432 RNA-Seq profiling of nup50c mutants October 18, 2025Contributors : Yu Tang ; Xiangyun YangSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPurpose: To understand the molecular mechanism and severe phenotype caused by the mutation of Nup50c, we performed the whole genome transcriptome analysis on 9-day-old seedlings of WT and nup50c. Conclusions: Nup50c regulates s […]
- GSE279812 Intercellular crosstalk within human preimplantation lineages regulates Trophectoderm specification October 18, 2025Contributors : Yan Bi ; Zhifen Tu ; Yixuan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensour study reconstructs a comprehensive communication network for human preimplantation lineages and integrates it with downstream gene regulatory networks, thus offering vital insights into lineage specification and cell fate […]
- GSE281411 Effect of silencing of DEPDC1 on gene expression in MDA-MB 231 TNBC cell line October 18, 2025Contributors : Giannino Del Sal ; Manuel Caputo ; Silvano Piazza ; Alessandra RustighiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDEPDC1 supports tumor growth, migration and metastases formation. To investigate what is the gene expression network regulated by DEPDC1, we silenced its expression in MDA-MB-231 Triple N […]
- GSE306871 Cathepsin D-Mediated MHC-I Degradation Contributes to Immune Evasion in Microsatellite Stable Colorectal Cancer October 18, 2025Contributors : Weixiang Zhan ; Yang Fu ; Yina Liu ; Runkai Cai ; Fan Bai ; Chenxu Guo ; Yi Cheng ; Zehua Wu ; Ge Qin ; Yuqian Xie ; Jianwei Zhang ; Yanhong DengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicrosatellite stable (MSS) colorectal cancer (CRC) is often characterized as a "cold" tumor, exhibitin […]
- GSE309577 4-Vinylcyclohexene diepoxide induces ovarian toxicity and oocyte damage in mice: mechanisms involving m6A/IGF2BP3-mediated meiotic mRNA stability regulation October 18, 2025Contributors : Yang Li ; Yu L Zhou ; Jian Liu ; Hong Y Yang ; Guang N Nie ; Fang P ChengSeries Type : OtherOrganism : Rattus norvegicusThis study investigates the role of m6A RNA methylation and IGF2BP3 in VCD-induced ovarian toxicity in mice. VCD exposure caused follicular depletion, oxidative stress, DNA damage, and meiotic defects in oocytes. Mechanistica […]