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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE140841 Subtle changes in brain expression modules in Alzheimer’s disease TREM2 carriers compared to non-carriers October 4, 2025Contributor : Guillermo CarbajosaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Rare heterozygous coding variants with a large effect on the risk of developing late-onset Alzheimer's disease (similar to ApoE4, OR 2.90-5.05) have been identified in the Triggering Receptor Expressed on Myeloid cells 2 (T […]
- GSE281546 Integrated Transcriptomics and Metabolomics Analysis Promotes the Understanding of Adventitious Root Formation in Toxicodendron succedaneum (L.) Kuntze October 4, 2025Contributors : Dan Zong ; ChengZhong He ; Cai Wang ; Dongxiao MaSeries Type : Expression profiling by high throughput sequencingOrganism : Toxicodendron succedaneumToxicodendron succedaneum is an important economic tree species. In the process of establishing a regeneration system for the T. succedaneum, it was found that the axillary buds that are produced […]
- GSE214843 A small CRISPR/Cas-associated RNA regulates ferrous iron transport in Neisseria meningitidis October 4, 2025Contributors : Denise Müller ; Thorsten Bischler ; Christoph SchoenSeries Type : Expression profiling by high throughput sequencingOrganism : Neisseria meningitidisIn this study the RNA targetome of the endonuclease Cas9, the trans-activating crRNA (tracrRNA) and a CRISPR-associated small RNA (scaRNA/NMnc0040) was determined in Neisseria meninigitidis serogr […]
- GSE309442 Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory [RNA-seq] October 4, 2025Contributors : Eamon Coughlan ; Tony TiganisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCAR T cells have been ineffective against solid tumors, where the hostile tumor microenvironment limits CAR T cell function and persistence. Here we have used CRISPR/Cas9 gene-editing, or a small molecule inhibitor to target prot […]
- GSE309443 Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory [scRNA-Seq] October 4, 2025Contributors : Eamon Coughlan ; Tony TiganisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCAR T cells have been ineffective against solid tumors, where the hostile tumor microenvironment limits CAR T cell function and persistence. Here we have used CRISPR/Cas9 gene-editing, or a small molecule inhibitor to target prot […]
- GSE309489 SPARC Upregulation Mediates Podocyte Injury in Alport Syndrome Mice October 4, 2025Contributors : Dongxuan Chi ; Hongyuan Chu ; Fang Wang ; Jing NieSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlport syndrome (AS) is a hereditary kidney disease with no curative treatment, which characterized by hematuria, proteinuria, and progressive kidney failure. Podocyte injury has been observed in AS, wherease […]
- GSE309580 Transcriptome profiling of pitp-1 mutant and pitp-1(RNAi)-treated Caenorhabditis elegans October 4, 2025Contributors : Yen-Hung Lin ; Tsiu-Ting Ching ; Chiou-Hwa Yuh ; Horng-Dar WangSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansThis dataset contains the transcriptome profiling results of Caenorhabditis elegans under pitp−1 regulation. The experiment was designed to identify the transcriptional mechanisms under […]
- GSE309699 Interferons inhibit Ebola virus infection of human keratinocytes October 4, 2025Contributors : Jonah Elliff ; Hanora Van Ert ; Kristina Sevcik ; Marija Djurkovic ; Danielle Rudd ; Francoise Gourronc ; Aloysius Klingelhutz ; Olena Shtanko ; Wendy MaurySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOrthoebolavirus zairense, or Zaire Ebola virus (EBOV) is a species within the virus family Filoviridae […]