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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE214960 Targeting dendritic cells with a PD-L1 based bispecific antibody rejuvenates specific anti-tumor T cells October 1, 2025Contributors : Longchao Liu ; Jiahui ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBispecific T-cell engagers (BiTEs) that preferentially target tumor-associated antigens to engage CD3 signaling have been approved to treat acute B-cell lymphoblastic leukemia. However, their applications in solid tumors have been h […]
- GSE245141 Transcriptome-wide RNA structure probing with temporal resolution October 1, 2025Contributors : Danyang Wang ; Yongkang Tang ; Ang Li ; Lei Sun ; Ralph E KleinerSeries Type : OtherOrganism : Homo sapiensReactive small-molecule probes are widely used for RNA structure probing, however current approaches largely measure average RNA transcript dynamics and do not resolve structural differences that occur during folding or transcript maturat […]
- GSE240537 A bone regenerative strategy based on extracellular vesicles transporting citrate for promoting biomineralization [QH] October 1, 2025Contributors : Wenjin Cai ; Jinglun Zhang ; Yufen ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe mineralization of extracellular matrix (ECM) rich in collagen is a biological process in many bones. It is well known that organic molecules from the extracellular matrix of mineralized tissues are crucial for cons […]
- GSE274676 Combinatorial BMP4 and Activin direct choice between alternate routes to endoderm during human gastrulation [scRNA-seq] October 1, 2025Contributor : Silvia SantosSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCellular differentiation requires the proper interpretation of multiple signalling cues which vary in concentration. How exactly the combination and history of signals a cell is exposed to influences a fate decision remains poorly understood. In […]
- GSE248744 FACT-mediated depletion of macroH2A-nucleosome regulates the cell response of macrophage October 1, 2025Contributor : Ping ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe histone variant macroH2A has been shown to generally associate with transcriptionally silent chromatin states. However, how macroH2A regulates the chromatin structure and functions in transcriptional process still remains elusive at the molecular […]
- GSE279453 Bifidobacterium lactis Derived Vesicles Attenuates Hippocampal Neuroinflammation via Targeting IL-33 to Regulate FoxO6/P53 Signaling October 1, 2025Contributors : Xiaoyu Du ; Haina GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHippocampal Neuroinflammation (HNF) is a critical driver of cognitive impairment. The lipo-polysaccharide (LPS) accumulate amyloid beta (Aβ) and lead to HNF. The Bifidobacterium lactis (BL) 99 have anti-inflammatory ability. However, the […]
- GSE277876 Disrupted developmental signaling induces novel transcriptional states October 1, 2025Contributors : Aleena L Patel ; Maria AvdeevaSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioSingle cell RNA sequencing was used to measure the transcriptional profiles of 50% epiboly zebrafish embryos treated with constitutive ERK signaling pathway activation by the optogenetic tool photoswitchable MEK or left untreated […]
- GSE309378 Mobile-CRISPRi as a tool for genetic manipulation in the intracellular pathogen Piscirickettsia salmonis October 1, 2025Contributors : Javiera Ortiz-Severin ; Paulette Geoffroy ; Pamela Aravena ; Christian Hodar ; Daniel E. Palma ; Mauricio González ; Verónica CambiazoSeries Type : Expression profiling by high throughput sequencingOrganism : Piscirickettsia salmonisPiscirickettsia salmonis is the causative agent of Salmonid Rickettsial Septicemia (SRS), the main bacterial dis […]
- GSE309364 RNA-Seq analysis of cancer models with altered SLX4/XPF reveals links to migration, DNA damage response, EMT, and drug sensitivity October 1, 2025Contributors : kamel chettab ; Emeline Cros-Perrial ; Léa Figuet ; Michaël Duruisseaux ; Charles Dumontet ; Lars Petter JordheimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSLX4 and XPF are two proteins involved in DNA repair mechanisms, but for which other properties are possible. After a study on phenotypes of cell […]
- GSE309391 Influence of hsa-miR-1265 and hsa-miR-21-5p on meningioma cells October 1, 2025Contributors : Paulina Kober ; Szymon Baluszek ; Mateusz BujkoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMeningiomas are common intracranial tumors. Most of thenm benign WHO GI tumors, while approximately 20% are diagnosed as progressively more aggressive GII and GIII meningiomas. The study aimed to identify genes […]
- GSE309387 SIRT6 regulates Tryptophan catabolism preventing metabolite imbalance and neurodegeneration October 1, 2025Contributors : Shai Kaluski-Kopatch ; Daniel Stein ; Alfredo Garcia-Venzor ; Ana Margarida Ferreira Campos ; Melanie Planque ; Bareket Goldstein ; Estefanía De Allende-Becerra ; Dmitrii Smirnov ; Adam Zaretsky ; Ekaterina Eremenko ; Miguel Portillo ; Monica Einav ; Alena Bruce Krejci ; Uri Abdu ; Ekaterina Khrameeva ; Daniel Gitler ; Sarah-Maria Fendt ; Debr […]
- GSE309404 Antagonizing Il10 and Il4 signaling via intracerebral decoy receptor expression attenuates Aβ accumulation October 1, 2025Contributors : Karen N McFarland ; Paramita Chakrabarty ; Todd E GoldeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMultiple lines of evidence indicate that immune signaling can impact the pathological progression in Alzheimer’s disease (AD), including amyloid deposition, tau aggregation, synaptic pathology and neurod […]
- GSE309570 Cytomegalovirus latency exacerbates cardiac inflammation and tissue remodeling after myocardial infarction October 1, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, with immune-mediated processes increasingly recognized as important contributors to CVD onset and progression. Seropositivity rates indicate 60–90% of the population car […]
- GSE309572 MLL2 facilitates long-range gene regulation through LINE1 elements [ChIP-Seq] October 1, 2025Contributors : Lara Z Shahidian ; Lucio di Filippo ; Sarah M Robert ; Álvaro Rada-IglesiasSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTranscriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), […]
- GSE280392 N6-Methyladenosine reader YTHDF3 regulate Sindbis virus release by incomplete selective autophagy flux maintenance through SQSTM1 October 1, 2025Contributors : Wei Ye ; Yajing ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensN6-methyladenosine (m6A) is vital for RNA metabolism and function and is one of the most abundant internal RNA modifications. Recently, m6A has been indicated in regulating replication of multiple viruses; however, the role of m6A in typic […]