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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE279822 Eif1ad3 as a key regulator during zygotic genome activation September 29, 2025Contributors : Z Jiang ; H MingSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusEif1ad3 with its homologs, including Eif1ad4, Eif1ad6, Eif1ad7, etc., which are barely studied before, are found to be highly translated during ZGA and regulating the translational activity of critical genes, especially for ribosome a […]
- GSE277917 Conserved and dynamic ESR1 signaling in developing cortex mediates early postnatal social behavior [snATAC-seq] September 29, 2025Contributors : Yuejia Liu ; Xinhe Zheng ; Xin Jin ; Longzhi TanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo dissect the genomic function of Esr1 in neonatal cortical neurons, we performed estradiol benzoate or vehicle treatment on P1 Esr1-Cre;LSL-Sun1-GFP animals and harvested the neocortex to perfor […]
- GSE290452 Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes [RNA-Seq] September 29, 2025Contributors : Nargess Farhangdoost ; Alessia Pietrantonio ; Yumin Liu ; Calwing Liao ; Daniel Rochefort ; Alain Pacis ; Martin Alda ; Patrick A Dion ; Boris Chaumette ; Anouar Khayachi ; Guy A RouleauSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBipolar disorder (BD) is a complex psychiatric condition usually requiri […]
- GSE283978 Maf1 cooperates with progesterone receptors to repress RNA polymerase III transcription of select tRNAs September 29, 2025Contributors : Jessica Finlay-Schultz ; Kiran V Paul ; Peter Kabos ; Carol A SartoriusSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensProgesterone receptors (PR) can regulate transcription by RNA Polymerase III (Pol III), which transcribes small non-coding RNAs, including all transfer RNAs (tRNAs). Previou […]
- GSE232845 Effect of conditional triple-knockout of Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c or overexpression of KDM4C/JMJD2C mutants with different phase separation ability on gene expression in mouse embryonic stem cells. [ChIP-Seq] September 29, 2025Contributors : Shaoshuai Jiang ; Xinyi LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo investigate the functions of JMJD2/KDM4 family in mouse embryonic stem cells (mESCs), we treat the the conditional triple-knockout mESCs of Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c with 4-hydroxytamoxifen (4-OHT […]
- GSE292392 Spatial Transcriptomics of Controlled vs Uncontrolled Tuberculosis in a Mouse Model September 29, 2025Contributors : Lester Kobzik ; Igor KramnikSeries Type : OtherOrganism : Mus musculusTo further characterize gene expression in controlled vs uncontrolled tuberculosis lung lesions, we performed spatial transcriptomics analysis using the NanostringGeoMX Digital Spatial Profiler (DSP) system.
- GSE309457 Voluntary exercise alleviates neural functional deficits in Parkinson’s disease mice by inhibiting microglial ferroptosis via SLC7A11/ALOX12 axis September 29, 2025Contributors : Jinghui Xu ; Xiaofei He ; Lili LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia are more susceptible to ferroptosis compared to neurons and astrocytes, which may compromise their phagocytic and clearance capabilities of α-synuclein (α-syn) in Parkinson’s disease (PD). While the beneficial effec […]
- GSE253176 DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms September 29, 2025Contributors : Stephanie Roessler ; Reka TothSeries Type : Methylation profiling by arrayOrganism : Homo sapiensNeuroendocrine neoplasms (NEN) are thought to originate from diffuse endocrine networks and therefore most frequently occur in the gastrointestinal tract and lungs. The liver is a frequent site of metastasis of NEN but also the presence of primary […]
- GSE309527 Combinatorial interactions between viral proteins expand the potential functional landscape of the tomato yellow leaf curl virus proteome September 29, 2025Contributors : Liping Wang ; Huang Tan ; Laura Medina-Puche ; Mengshi Wu ; Borja Garnelo Gomez ; Man Gao ; Chaonan Shi ; Tamara Jimenez-Gogonra ; Pengfei Fan ; Xue Ding ; Dan Zhang ; Yi Ding ; Tábata Rosas-Díaz ; Yujing Liu ; Emmanuel Aguilar ; Xing Fu ; Rosa Lozano-DuránSeries Type : Expression profiling by high throughput sequencingOrganism : Nicotiana ben […]
- GSE309509 System biology reveals a mechanism associated with protection by the co-immunization of DNA and protein in the same anatomical site (LN) September 29, 2025Contributors : Slim Fourati ; Michael Gale ; Rafick-Pierre Sekaly ; Barbara B Felber ; George N PavlakisSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaSystem immunology was used to identify the mechanisms linked to the immunogenicity and protective efficacy of an HIV vaccine comprised of Env and Gag DNA and Env prote […]
- GSE309534 Single-cell profiling of the human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia September 29, 2025Contributors : Karin D Prummel ; Kevin Woods ; Maksim Kholmatov ; Eric C Schmitt ; Evi P Vlachou ; Mayssa Labyadh ; Rebekka Wehner ; Gereon Poschmann ; Kai Stühler ; Susann Winter ; Uta Oelschlaegel ; Manja Wobus ; Logan S Schwartz ; Pedro L Moura ; Eva Hellström-Lindberg ; Krishnaraj Rajalingam ; Matthias Theobald ; Jennifer J Trowbridge ; Clémence Carron ; […]
- GSE309536 Single-cell profiling of the human bone marrow stromal cells in clonal hematopoiesis and myelodysplasia September 29, 2025Contributors : Karin D Prummel ; Kevin Woods ; Maksim Kholmatov ; Eric C Schmitt ; Evi P Vlachou ; Mayssa Labyadh ; Rebekka Wehner ; Gereon Poschmann ; Kai Stühler ; Susann Winter ; Uta Oelschlaegel ; Manja Wobus ; Logan S Schwartz ; Pedro L Moura ; Eva Hellström-Lindberg ; Krishnaraj Rajalingam ; Matthias Theobald ; Jennifer J Trowbridge ; Clémence Carron ; […]
- GSE309538 Expression profiling of the human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia [PanCancer] September 29, 2025Contributors : Karin D Prummel ; Kevin Woods ; Maksim Kholmatov ; Eric C Schmitt ; Evi P Vlachou ; Mayssa Labyadh ; Rebekka Wehner ; Gereon Poschmann ; Kai Stühler ; Susann Winter ; Uta Oelschlaegel ; Manja Wobus ; Logan S Schwartz ; Pedro L Moura ; Eva Hellström-Lindberg ; Krishnaraj Rajalingam ; Matthias Theobald ; Jennifer J Trowbridge ; Clémence Carron ; […]
- GSE274891 Effect of temozolomide resistant on gene expression in mouse neuroblastoma tumor [ChIPseq] September 29, 2025Contributors : Tong Liang ; Evon Poon ; Louis Chesler ; Charles LinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAdvances in preclinical models that recapitulate chemorefractory and relapsed disease are needed to better predict the efficacy of an expanding and promising armamentarium of drug candidates b […]
- GSE309379 Nucleophosmin supports WNT-driven hyperproliferation and tumour initiation September 29, 2025Contributors : Georgios Kanellos ; Mark White ; Megan L Mills ; Kathryn L Gilroy ; Andrew D Campbell ; Owen J SansomSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNucleophosmin (NPM1), a nucleolar protein frequently mutated in haematopoietic malignancies, is overexpressed in several solid tumours with poorly understood […]