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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE278244 Collagen XXIII (Col23a1): A novel risk factor for eczema herpeticum September 27, 2025Contributors : Chopra Shruti ; Traidl Stephan ; Döhner Katinka ; Roesner Lennart M. ; Werfel ThomasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Eczema herpeticum (EH) is a potentially life-threatening disseminated skin infection caused by herpes simplex virus (HSV) in a subset of atopic dermatitis (AD) pat […]
- GSE278333 Bulk RNA sequencing SCA1+ fibroblasts from murine skin in the uninjured state and 16 hours, 1.5 days, and 3 days post-wounding September 27, 2025Contributors : Veronica Amuso ; MaryEllen Haas ; Anelia Horvath ; Brett ShookSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFibroblasts are emerging as potent modulators of wound-induced inflammation in the skin. We have observed that fibroblasts expressing the surface marker SCA1 are enriched for expression of proinfl […]
- GSE278251 Gnai1+ stromal cells regulate intestinal goblet and Paneth cell differentiation through c-Jun signaling September 27, 2025Contributors : Ye-guang Chen ; Yalong Wang ; Wanlu SongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCombining single-cell and spatial transcriptomics for mapping different intestinal segments is still relatively absented, and the subtypes of intestinal stromal cells and their downstream signling also remain obscure. […]
- GSE214261 Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice September 27, 2025Contributors : Yongquan Yu ; Yucheng Wang ; Yu Dong ; Shuge ShuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPhthalates are a group of neurotoxicants with cognitive-disrupting potentials. Given the structural diversity of phthalates, the corresponding neurotoxicity is dramatically altered. To identify the potential co […]
- GSE308876 Dorsal Root Ganglion-Mediated Modulation of Neuroinflammation and Neurovasodilation in Rosacea by Gabapentin September 27, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeurogenic rosacea features disproportionate pain and erythema resistant to conventional treatments. While gabapentin shows clinical efficacy, its molecular mechanism remains undefined.Using a murine rosacea model induced by LL37, we performed bulk RNA sequencing and molec […]
- GSE273315 Reprogramming of H3K36me2 guides lineage- and locus-specific post-implantation DNA methylation [methylation] September 27, 2025Contributors : Xukun Lu ; Lijuan Wang ; Yu Zhang ; Wei XieSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusIn mammals, DNA methylation is rapidly re-established after implantation following global erasure in pre-implantation embryos, the regulation of which, however, is not completely understood. Here, by mapping H3K36m […]
- GSE244554 Identification of SLC7A1 as a potential therapeutic target for high-grade meningioma September 27, 2025Contributor : Lairong SongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHigh-grade meningioma remains a therapeutic challenge to medical oncologists. It is urgent to uncover novel molecular targets. Solute carrier family 7 member 1 (SLC7A1) was highly expressed in high-grade meningioma and associated with poor prognos […]
- GSE290649 Microproteins Simba1 and Simba2 Activate Wingless Signaling during the Reactivation of Neural Stem Cells in Drosophila September 27, 2025Contributors : Jiaen Lin ; Hongyan Wang ; Lay-Keng Tan ; Patrick TanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterThe ability of neural stem cells (NSC) to switch between quiescent and proliferative states is fundamental for adult neurogenesis and regeneration. Microproteins or short open read […]
- GSE284714 AMPK signaling downstream of adenosine 2A receptor represses Th17 cell pathogenicity through epigenetic and metabolic reprogramming. September 27, 2025Contributors : Gina Papadopoulou ; Dimitrios Valakos ; Georgina XanthouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMetabolic reprogramming controls protective or pathogenic Th17 cell responses; still, the precise molecular pathways that drive distinct immunometabolic states remain elusive. Here, we dem […]
- GSE303579 Integrin/CD44-Targeted Liposomal Co-Delivery of Nintedanib and Dexamethasone for Acute Exacerbation of Idiopathic Pulmonary Fibrosis September 27, 2025Contributors : Xinmei Huang ; Yingwei Zhang ; Mengshu Cao ; Yonglong XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAcute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) poses a significant clinical challenge due to its high morbidity and mortality, coupled with a lack of effective targeted therapies. Here, […]
- GSE294197 Ultra-mild bisulfite outperforms EM-seq for 5-methylcytosine detection with low inputs DNA September 27, 2025Contributors : Ruitu Lyu ; Qing Dai ; Tanner Baldwin ; Bryan DanielsSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHere we present Ultra-Mild Bisulfite Sequencing (UMBS-seq), which minimizes DNA damage and background noise while detecting 5-methylcytosine (5mC) in DNA. When applied to low-input lambda DNA (5 ng-10 pg) […]
- GSE308783 Bulk RNA sequencing reveals the alterations in gene expression levels of myocardial tissues from mice after myocardial infarction September 27, 2025Contributors : Congyi Cheng ; Chunlin Wang ; Weichun Zhu ; Chungang Zhai ; Lei Qiao ; Wenqiang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGene expression alterations in myocardial tissues following acute myocardial infarction (AMI) are of great significance for studying the pathophysiological mechanisms of this […]
- GSE308797 Bulk RNA-seq of MDA-MB-231 cells under dasatinib treatment September 27, 2025Contributors : Xinyu Guo ; Heng Sun ; Feng Yu ; Rong Zhou ; Chu-xia DengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTriple-negative breast cancer (TNBC) is characterized by high metastatic potential and poor prognosis, underscoring the urgent need for effective therapeutic strategies. Dasatinib emerged as a promisin […]
- GSE308817 Human Pluripotent Stem Cell-Derived Alveolar Organoids for Gene-editing and Lung Adenocarcinomas Modeling September 27, 2025Contributors : Lian Li ; Yuchen Liu ; Zhili Rong ; Ying LinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman pluripotent stem cell (hPSC)-derived alveolar organoids have emerged as valuable tools for studying lung development, modeling pulmonary diseases, and drug discovery, though their application has been hindere […]
- GSE276385 PRMT5/WDR77 moonlights as an RNA-binding complex and shapes T cell function and anti-tumor immunity via post-transcriptional regulation of PDCD1 September 27, 2025Contributors : Yinmin Gu ; Shan GaoSeries Type : OtherOrganism : Homo sapiensTo reveal the potential RNA targets of PRMT5 in jurkat cells, we performed Flag Immunoprecipitation sequencing (RIP-seq) in PRMT5-Flag overexpression (OE) jurkat cells after stimulated with polyhydroxyalkanoates (PHA) for 48 hours.