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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE214155 RNA-sequencing assay to Identify changed gene expression in stomach adenocarcinoma (STAD) cells with SMYD3 knockdown September 25, 2025Contributors : Jingyu Deng ; Yong Liu ; Yi Zeng ; Gang MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: To elucidate how SMYD3 influenced the expression profile in STAD cells, SMYD3 expression was reduced using one shRNA in STAD HGC-27 and SGC-7901 cells. Then, transcriptional profiling of cells with SMYD3 kno […]
- GSE214340 Genomewide analysis of S6K1-depleted human dorsal forebrain organoids [RNA-seq] September 25, 2025Contributors : Ki H Nam ; Sang A Yi ; Lin-Fan Xiao ; Ning-Yi Shao ; Jaecheol Lee ; Jeung-Whan HanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo elucidate the role of S6K1 in human brain development, we performed next-generation sequencing-based genomweide analysis of S6K1 knockout (KO) human embryonic stem cells (ES […]
- GSE214296 miRNA expression profiles of garlic-derived exosomes September 25, 2025Contributors : Yangping Bian ; Li Yin ; Jianhui LiuSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Allium sativumIn this study, we investigated the miRNA profiling of garlic-derived exosomes and screened the miRNAs associated with the expression of 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3), one of the crit […]
- GSE250383 circRNAs expression profile analysis of PK-15 cells response to transmissible gastroenteritis virus infection September 25, 2025Contributor : Xiwang YangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Sus scrofaTo analyze the effect of Transmissible gastroenteritis virus (TGEV) infection on expression profile of circular RNAs (circRNAs) in pig renal epithelial cells (PK-15), we decided to sequence the circRNAs transcriptome of control and TGEV-infected […]
- GSE232448 Genomewide analysis of S6K1-depleted human dorsal forebrain organoids [single-cell RNA-seq] September 25, 2025Contributors : Ki H Nam ; Sang A Yi ; Lin-Fan Xiao ; Ning-Yi Shao ; Jaecheol Lee ; Jeung-Whan HanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo elucidate the role of S6K1 in human brain development, we performed next-generation sequencing-based genomweide analysis of S6K1 knockout (KO) human embryonic stem cells (ES […]
- GSE266030 The chromatin remodeler CHD1L controls human cortical neurogenesis and contributes to distal 1q21.1 deletion/duplication syndrome [RNA-seq] September 25, 2025Contributors : Maria-Nicla Loviglio ; Céline Keime ; Christelle GolzioSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground/objectives: Deletions and duplications of the distal 1q21.1 region are associated with syndromic forms of autism (MIM612474, 612475). Variable phenotypes have been reported, including congenit […]
- GSE253099 CRISPRi Screening of Enhancers in Human Primary Astrocytes Identifies Regulatory Circuitry Disrupted in Alzheimer’s Disease [RNA-seq] September 25, 2025Contributors : Nicole F Green ; Gavin J Sutton ; Samuel Bagot ; Hannah Danon ; Juli Wang ; Akira Gokool ; Samantha Miles ; Charles A Herring ; Hamid Alinejad-Rokny ; Ryan Lister ; Joseph Rosenbluh ; Johann A Gagnon Bartsch ; Irina VoineaguSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used CROP-seq to perform a high […]
- GSE306483 The impact of hsa_circ_0001910 on downstream gene expression changes in breast cancer cells September 25, 2025Contributors : Yang Sang ; Fei LiuSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate the impact of hsa_circ_0001910 on downstream genes in breast cancer cells, we knocked down the expression of hsa_circ_0001910 in MDA-MB-231 cells and observed the changes in downstream gene expression.
- GSE296848 ChIP-Seq of NR1D1 in Hep3B cells September 25, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGenome-wide measurements of transcripton factos binding in Hep3B cells to study NR1D1 regulate the tumorigenic programs
- GSE308701 Fatty acid-activated proton transporter SR4 prevents hepatic steatosis and metabolic alterations in diabetic mice by improving mitochondria function, energy balance and oxidative stress September 25, 2025Contributors : James L Figarola ; Jyotsana Singhal ; Sharad SinghalSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusType 2 diabetes (T2D) is a growing global health crisis, largely driven by rising obesity rates. Untreated T2D leads to severe complications such as cardiovascular disease, nephropathy, retinopathy, neuropa […]
- GSE308700 MIAT-DHX9 spatiotemporal expression drives venous neointimal hyperplasia through nucleolar homeostasis and mitotic progression September 25, 2025Contributors : Yue Lou ; Wen-hao Tian ; Jia-long Cui ; Guo-zhu Sun ; Fan Lv ; Xian-hui Liang ; Kai Huang ; Qing-ping Yao ; Ying-xin QiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusVenous neointimal hyperplasia, characterized by the abnormal proliferation of smooth muscle cells (SMCs), represents a critical contri […]
- GSE308752 Translatome of Dorsal Striatum Parvalbumin interneurons revisited: insights across diverse experimental paradigms [RNA-Seq] September 25, 2025Contributors : Emmanuel Valjent ; Laura CutandoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusParvalbumin (PV) interneurons in the dorsal striatum (DS) are fast-spiking GABAergic cells critical for feedforward inhibition and synaptic integration within basal ganglia circuits. Despite their well-characterized electrophy […]
- GSE308753 Translatome of Dorsal Striatum Parvalbumin interneurons revisited: insights across diverse experimental paradigms [RiboTag] September 25, 2025Contributors : Emmanuel Valjent ; Laura CutandoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusParvalbumin (PV) interneurons in the dorsal striatum (DS) are fast-spiking GABAergic cells critical for feedforward inhibition and synaptic integration within basal ganglia circuits. Despite their well-characterized electrophy […]
- GSE308756 MIAT-DHX9 spatiotemporal expression drives venous neointimal hyperplasia through nucleolar homeostasis and mitotic progression. September 25, 2025Contributors : Yue Lou ; Wenhao Tian ; Jialong Cui ; Guozhu Sun ; Fan Lv ; Xianhui Liang ; Kai Huang ; Qingping Yao ; Yingxin QiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusVenous neointimal hyperplasia, characterized by the abnormal proliferation of smooth muscle cells (SMCs), represents a critical contributor […]
- GSE308802 Promoter competition and Polycomb Response Elements govern transvection efficiency between co-regulated engrailed and invected genes in Drosophila. September 25, 2025Contributors : Yuzhong Cheng ; Adrienne T Perkins ; Fountane W Chan ; Natalie D Gehred ; Jack R Bateman ; Judith A KassisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterTransvection is a phenomenon where gene regulatory elements interact between different chromosomes, adding an additional layer […]