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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE271033 Toss GERALT into chloroplast to make it green: an age-dependent regulator of chloroplast biogenesis and chlorophyll biosynthesis. September 18, 2025Contributors : Agnieszka K Banaś ; Joanna Grzyb ; Piotr Zgłobicki ; Andrzej Pacak ; Beata Myśliwa-Kurdziel ; Katarzyna Leja ; Małgorzata Kozieradzka-Kiszkurno ; Kinga Kłodawska ; Robert Konieczny ; Maria Pilarska ; Ewa Niewiadomska ; Aneta Bażant ; Łukasz Szewc ; Ewa B Kowalska ; Wojciech StrzałkaSeries Type : Expression profiling by high throughput sequenci […]
- GSE253186 Evaluation of PFHpA impact on liver metabolism using human liver spheroids September 18, 2025Contributors : A C Maretti-Mira ; M P Salomon ; L Golden-MasonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAccumulating evidence suggests that poly- and perfluoroalkyl substances (PFAS), a class of persistent organic pollutants, cause changes in hepatic lipid, amino acid, and glucose metabolism. Our study explores th […]
- GSE275705 Extrachromosomal DNA Associates with Nuclear Condensates and Reorganizes Chromatin Structures to Enhance Oncogenic Transcription [RNA-seq II] September 18, 2025Contributors : Harianto Tjong ; Chia-Hao Tung ; Aziz Taghbalout ; Ping Wang ; Chia-Lin WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExtrachromosomal, circular DNA (ecDNA) is a prevalent and significant oncogenic alteration in cancer genomes. Its frequency is associated with aggressive tumor behavior and poor patie […]
- GSE275054 Extrachromosomal DNA Associates with Nuclear Condensates and Reorganizes Chromatin Structures to Enhance Oncogenic Transcription [ChIA-PET] September 18, 2025Contributors : Harianto Tjong ; Chia-Hao Tung ; Aziz Taghbalout ; Ping Wang ; Chia-Lin WeiSeries Type : OtherOrganism : Homo sapiensExtrachromosomal, circular DNA (ecDNA) is a prevalent and significant oncogenic alteration in cancer genomes. Its frequency is associated with aggressive tumor behavior and poor patient outcome. To understand how ecDNA promotes […]
- GSE279780 Integrated miRNA-mRNA Analyses of Triple-Negative Breast Cancer in Black and White Patients with or Without Obesity September 18, 2025Contributors : Fokhrul Hossain ; Martha I Gonzalez-Ramirez ; Jone Garai ; Diana Polania-Villanueva ; Li Li ; Farzeen Nafees ; Md Manirujjaman ; Bolin Bolin ; Samarpan Majumder ; Xiao-Cheng Wu ; Chindo Hicks ; Luis Del Valle ; Denise Danos ; Augusto Ochoa ; Lucio Miele ; Jovanny ZabaletaSeries Type : Non-coding RNA profiling by high throughput sequencingOrgan […]
- GSE277433 Disrupting YAP phase separation attenuates the development of primary liver cancer in animal models September 18, 2025Contributors : Shuang-zhou Peng ; Fu-quan Jiang ; Lijun Cai ; Jia-jia LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn these murine liver cancer samples, we used specific antibody detection to find endogenous YAP formation condensates in the focal area, a phenomenon also observed in human liver cancer tissues. De […]
- GSE307689 Transcriptomic Insights into the Host Response to MPXV Infection in Human Neuronal Cells September 18, 2025Contributors : Qiangming Sun ; Zhengcun Wu ; Haiting Long ; Tingfu DuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Monkeypox virus (MPXV) is a neurotropic zoonotic pathogen, as evidenced by neurological symptoms in patients and its demonstrated neuroinvasive potential in both in vitro and in vivo models. However, […]
- GSE282649 RNA-seq analysis of human iPSC derived hepatocyte and stellate cell surround organoids (iHSOs) September 18, 2025Contributors : Tomohiro Mochida ; Masato Miyoshi ; Sei KakinumaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the interaction between hepatocytes and hepatic stellate cells in iHSOs, we established contact co-culture organoids using iPSC-derived HSCs and hepatocytes; termed iPSC-derived hepatocyte-stella […]
- GSE308027 Engineered Nanobodies Targeting Endogenous Digoxin-like Substances Function as Novel Immune Checkpoints Inhibitors and Enhance Immunotherapy against Cancer Metastasis September 18, 2025Contributors : Yan Chen ; Chenming Xu ; Wu YinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDigoxin is a well-recognized cardiovascular medication; however, epidemiological investigations have associated its clinical application with an elevated risk of malignancy. To elucidate it, we discovered, for the first time, t […]
- GSE307747 RNA sequencing of PDX-AML samples using prime-seq September 18, 2025Contributors : Irmela Jeremias ; Binje Vick ; Tobias Herold ; Wolfgang Enard ; Johannes BagnoliSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe established serially transplantable and robust, genetically engineered patient derived xenograft (PDX) models of acute myeloid leukemia (AML).
- GSE308065 A NEW DYSTROPHIN DEFICIENT RAT MODEL MIRRORING EXON SKIPPING IN PATIENTS WITH DMD EXON 45 DELETIONS September 18, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusMutations in the dystrophin (DMD) gene can cause muscle-wasting disorders ranging from the milder Becker muscular dystrophy (BMD) to the more severe Duchenne muscular dystrophy (DMD). Exon 45 deletion is the most frequently reported single-exon deletion in DMD patient […]
- GSE308267 Aberrant fibro-adipogenic progenitor subpopulations drive volumetric muscle loss-induced fibrosis September 18, 2025Contributors : Lauren A Hymel ; Edward A Botchwey ; Emily Greenwood ; Seul LeeSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusVolumetric muscle loss (VML) injuries result in chronic fibrosis, inflammation, and persistent functional deficits. Fibro-adipogenic progenitor (FAP) cells are a heterogeneous, muscle-res […]
- GSE308360 Lactate promotes cholesterol uptake by facilitating SCARB1 expression through histone H3K18 lactylation September 18, 2025Contributors : Jiamin Chen ; Kengcheng Liu ; Mingyue Zhao ; Shengqi Shen ; Shi-Ting Li ; Jin Cai ; Guanxu Ji ; Linchong Sun ; Ping Gao ; Tong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetabolic reprogramming supports the proliferation of cancer cells under hypoxic stress, including enhanced glycolysis and alt […]
- GSE287908 Totipotent-Like Cell-Based Embryo Model Recapitulating Mouse Embryogenesis from Pre-Implantation to Gastrulation [RNA-Seq] September 18, 2025Contributors : Yixuan Ren ; Xuyang Wang ; Haiyin Liu ; Yaxing Xu ; Ruoqi Cheng ; Cheng Li ; Hongkui Deng ; Jun XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculus The development of stem-cell-derived models of mammalian embryogenesis has provided invaluable tools for investigating embryo development. However, constructin […]
- GSE307040 Cell-extrinsic controls over neocortical neuron fate and diversity [snRNAseq] September 18, 2025Contributors : Natalia Baumann ; Sabine Fièvre ; Ilaria Morassut ; Esther Klingler ; Giorgia Bartolini ; Sergi Roig PuiggrosSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeocortical cellular diversity emerges gradually during development. Cell-extrinsic interactions shape this extended maturation, yet cell-type-specif […]