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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE269396 Targeting RhoA activity rejuvenates aged hematopoietic stem cells [bulk ATAC-seq confinement] August 29, 2025Contributors : Eva M Mejía-Ramírez ; Sara Montserrat-Vazquez ; Maria C FlorianSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Biomechanical alterations contribute to the decreased regenerative capacity of hematopoietic stem cells (HSCs) upon aging. RhoA is a key regulator of mechano-signaling but its role for mechanot […]
- GSE246075 Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity [human ChIP-seq] August 29, 2025Contributors : Luís Henriques-Oliveira ; Abigail Altman ; Ilia Kurochkin ; Carlos-Filipe PereiraSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Transcription factor cooperation is essential for specifying the heterogeneous dendritic cell (DC) lineages that orchestrate adaptive immunity, yet how it drives subset divers […]
- GSE276083 Single cell spatial transcriptome and RNA-seq analysis in human lung tissues with mycobacterial infection: Single cell spatial transcriptome August 29, 2025Contributors : Harutaka Katano ; Yoshihiko HoshinoSeries Type : OtherOrganism : Tuberculosis and non-tuberculous mycobacterial (NTM) diseases are infections caused by Mycobacterium tuberculosis and non-tuberculous mycobacteria, leading to the formation of granulomatous lesions with caseous necrosis in the lungs.We applied spatial transcriptomics at single-ce […]
- GSE275961 Intestinal and mesenteric artery formation by intestine-derived prearterial endothelial cells August 29, 2025Contributors : Esther Bovay ; Kai Kruse ; Emma C Watson ; Vishal Mohanakrishnan ; Mark L Kahn ; Ralf H AdamsSeries Type : Expression profiling by high throughput sequencingOrganism : The cellular and molecular mechanisms mediating arterial development remain little understood for most organs. Here, we show that a small subpopulation of endothelial cells insi […]
- GSE284561 FACT depletion demonstrates a role for nucleosome organization in TAD formation August 29, 2025Series Type : OtherOrganism : This SuperSeries is composed of the SubSeries listed below.
- GSE278026 Platelets induce endothelial cell mitochondrial dysfunction in myocardial infarction August 29, 2025Contributors : Haoyu Sun ; Florencia Schlamp ; Sarah Liberow ; Nathaniel R Smilowitz ; Judith S Hochman ; Harmony R Reynolds ; Tessa J Barrett ; Jeffrey S BergerSeries Type : Expression profiling by high throughput sequencingOrganism : Coronary endothelial dysfunction playsa key role in the pathogenesis of cardiovascular events. In the setting of myocardial […]
- GSE306357 Sclerotic GvHD and Scleroderma Share Dysregulated Gene Expression that is Ameliorated by EREG Therapeutic Antibody August 29, 2025Contributor : Ian D OdellSeries Type : Expression profiling by high throughput sequencingOrganism : Immune driven fibrotic skin diseases including scleroderma/systemic sclerosis (SSc) and chronic graft-versus-host-disease (cGvHD) cause skin stiffening that has major impact on patient quality of life and associated patient mortality. Therapies to improve scle […]
- GSE215130 Gene expression profile at single cell level of tumor infiltrated CD45+ cells in liver tumors August 29, 2025Contributors : Steven X Hou ; Yuetong Wang ; Qiaoming LiSeries Type : Expression profiling by high throughput sequencingOrganism : CD45+ cells are considered as important componants of tumor immuno microenvironment. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of CD45+ cells in liver tumor treated with ARF1 inhibitor.
- GSE306413 Preadipocyte uncoupling protein 1 expression invoked by fibroblast growth factors imprints on post-differentiation white and brown adipocyte function [1] August 29, 2025Contributors : Katharina Kuellmer ; Tobias FrommeSeries Type : Expression profiling by high throughput sequencingOrganism : The presence of uncoupling protein 1 (UCP1) is a hallmark of thermogenic adipocytes and enables heat production by dissipating energy from mitochondrial proton motive force as heat. The purpose of its recently discovered presence in pre […]
- GSE306412 Preadipocyte uncoupling protein 1 expression invoked by fibroblast growth factors imprints on post-differentiation white and brown adipocyte function [2] August 29, 2025Contributors : Katharina Kuellmer ; Tobias FrommeSeries Type : Expression profiling by high throughput sequencingOrganism : The presence of uncoupling protein 1 (UCP1) is a hallmark of thermogenic adipocytes and enables heat production by dissipating energy from mitochondrial proton motive force as heat. The purpose of its recently discovered presence in pre […]
- GSE306745 Eupatilin Ameliorates Spinal Cord Injury by Inhibiting Damage-associated Microglia and Optimizing the Regenerative Microenvironment August 29, 2025Contributors : Weitao Man ; Zide WangSeries Type : Expression profiling by high throughput sequencingOrganism : Microglia represent critical therapeutic targets in spinal cord injury (SCI), with damage associated microglia (DAM) playing key roles in neuroinflammation and tissue repair.Through integrated in-silico analysis of scRNA-seq and microarray datasets […]
- GSE306800 Extracellular matrix-myCAF signatures correlate with resistance to neoadjuvant aPD-L1 immune checkpoint inhibition with durvalumab + metformin in HPV+ HNSCC August 29, 2025Contributors : Pablo Llerena ; Hani Samarah ; Kathryn L Nunes ; Zhao Lin ; Kelly Bridgham ; Sruti Tekumalla ; Amiti Jain ; Larry A Harshyne ; Sanket Shukla ; Ioannis A Vathiotis ; Madalina Tuluc ; Stacey M Gargano ; John R Eisenbrey ; Scott W Keith ; David M Cognetti ; Voichita Bar-Ad ; Adam J Luginbuhl ; Rita S Axelrod ; Rajanikanth Vadigepalli ; Hushan Yan […]
- GSE306842 Physiological and functional characterization for high-throughput optogenetic skeletal muscle exercise assays [30min] August 29, 2025Contributors : Ronald Heisser ; Angel Bu ; Ritu RamanSeries Type : Expression profiling by high throughput sequencingOrganism : Exercise has long been considered an essential part of human health and longevity. Recent physiological studies have expanded muscle’s role beyond simply acting as an actuator, revealing muscle’s exercise-mediated paracrine and endo […]
- GSE242315 Gene expression of hepatocellular carcinoma tissue in China Medical University Hospital (CMUH) cohort of Taiwanese patients August 29, 2025Contributors : Wen-Lung Ma ; Wei-Chung Cheng ; Pei-Yin Liao ; Wen-Jen LinSeries Type : Expression profiling by high throughput sequencingOrganism : It’s unknown what, how, and why lipid metabolites involve in cancer prognosis. This work implementing multi-omics measurement in hepatocellular carcinoma (HCC) patient cohort to associate tumoral lipidome, transc […]
- GSE306223 Effects of Acute and Chronic Type I Interferon Stimulation on Human Cardiomyocytes August 29, 2025Contributors : Arati Naveen Kumar ; Trinitee Oliver ; Caroline JefferiesSeries Type : Expression profiling by high throughput sequencingOrganism : Persistent type I interferon activity is a hallmark of systemic lupus erythematosus (SLE) and contributes to extra-renal organ injury, yet the temporal transcriptomic response of human cardiomyocytes has not been […]