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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE288479 Multiomics analysis of lung adenocarcinoma manifesting as radiological part-solid features in female never-smokers August 27, 2025Contributors : Junsu Choe ; Jinyeong Lim ; Noeul Kang ; Eun Seop Seo ; Mina Hwang ; Se-Hoon Lee ; Myung-ju Ahn ; Yoon-La Choi ; Hong Kwan Kim ; Woong-Yang Park ; Sang-Won UmSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensLung adenocarcinomas (LUADs) with part-solid radiological features exhibit slow progression […]
- GSE285137 A phosphorylation switch within the Mediator subunit MED15 controls cellular senescence and cognitive decline [ChIP-seq] August 27, 2025Contributors : Haozheng Li ; Yuanming Zheng ; Gang WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensA hallmark of aging is chronic systemic inflammation, which is exacerbated by the hypersecretory aging phenotype known as the senescence-associated secretory phenotype (SASP). How the SASP is initiated to […]
- GSE212476 Skin expression data from psoriasis patients treated with IL-17A inhibitor August 27, 2025Contributors : Jie Zheng ; Lihong Chen ; Li ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPsoriasis is a chronic, recurrent, inflammatory systemic disease that affects approximately 2-3% of the population worldwide. IL-17A plays a key pathogenic role in psoriasis, and IL-17A antigen have emerged as first-line age […]
- GSE291163 Testing the contribution of FGL1 to the pathogenesis of metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma August 27, 2025Contributors : Leon Kautz ; Jean PersonnazSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetabolic dysfunction-associated steatotic liver disease (MASLD) begins with simple steatosis, which can progress to hepatocellular carcinoma (HCC). The pathogenesis of MASLD alters the secretion of hepatokines such as fibrinogen-l […]
- GSE272980 BAT and SAT Treg cells and of BAT tissue with or without Treg cells under different experimental conditions [scRNA-seq] August 27, 2025Contributors : Nathan Zammit ; Diane Mathis ; Christophe BenoistSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusProfiling Treg cells from BAT,SAT,VAT,SPLN
- GSE267866 Systemic inflammation–induced adipose tissue remodeling drives psoriasis exacerbation in obesity through epigenetic and immunometabolic dysregulation August 27, 2025Contributors : YunJae Jung ; HeeJoo Kim ; IkSoo Kim ; Mijoo AhnSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Mus musculusObesity is a risk factor for psoriasis and negatively influences the severity, treatment responsiveness, and systemic comorbidities of […]
- GSE306206 Fine Mapping and Functional Characterization of qKRN5.04b Reveals ZmGrx5 as a Domestication-Selected Regulator of Kernel Row Number in Maize August 27, 2025Contributors : Min Zhu ; Fanrui Zeng ; Hu Yang ; Alessandra M York ; Shunyuan Chen ; Ronghao Guo ; Qianyi Huang ; Kanglan Yang ; Haishan Luo ; Fenghai Li ; Wanli Du ; Wei XueSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysKernel row number (KRN) is not only a key agronomic trait influencing maize yield but also a phenotype […]
- GSE279947 BAG2 inhibits the proliferation and migration of cervical cancer by slowing the degradation of STING August 27, 2025Contributors : Shijie Yao ; Hongbing CaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe fourth most prevalent illness in the world among women, cervical cancer has significant negative effects on both health and the economy in addition to high rates of morbidity and death. Understanding its molecular basis to guide […]
- GSE306225 Distinct 5′ and 3′ Coverage Biases Shape Transcriptome Interpretation in Nanopore Direct RNA versus PCR-cDNA Sequencing August 27, 2025Contributor : Cribbs AdamSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLong-read RNA sequencing enables isoform-resolved transcriptomics, but library preparation introduces systematic biases that shape biological interpretation. We benchmarked Oxford Nanopore’s two protocols—PCR-cDNA and direct RNA—using SKMM2 myeloma […]
- GSE306209 Preadipocyte uncoupling protein 1 expression invoked by fibroblast growth factors imprints on post-differentiation white and brown adipocyte function [iBAT] August 27, 2025Contributors : Katharina Kuellmer ; Tobias FrommeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe presence of uncoupling protein 1 (UCP1) is a hallmark of thermogenic adipocytes and enables heat production by dissipating energy from mitochondrial proton motive force as heat. The purpose of its recently discovered pre […]
- GSE306282 RNA-seq Analysis of Drosophila melanogaster Heads Harvested 4-Hours Post-PenetratingTraumatic Brain Injury August 27, 2025Contributors : Khailee Marischuk ; Shawn Ahern-Djamali ; Kassi L Crocker ; Grace Boekhoff-FalkSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterWe are utilizing an adult penetrating traumatic brain injury (PTBI) model in Drosophila to investigate early regenerative mechanisms after damage to the central brain. […]
- GSE306330 RNA-seq of RB1-biallelic inactivation mice and HCC cell lines treated with drug August 27, 2025Contributors : Jihyun An ; Wonkyung Kim ; Jin-Sung Ju ; Bora Oh ; Eun Ju Yang ; Yue Pu ; Li-Jie Chen ; Joong Sup Shim ; Chang Ohk Sung ; Ju Hyun ShimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the effect of RB1 biallelic inactivation on drug response, RNA-seq analysis was conducted on xenograft mouse […]
- GSE306338 The multiscale distribution of radiation-induced DNA damage and its impact on local genome structure August 27, 2025Contributors : Heng Li ; Tianchun Xue ; Rachel P McCordSeries Type : OtherOrganism : Homo sapiensThe three-dimensional genome structure is critical for the regulation of gene expression and repair of DNA damage. While previous work has characterized genome-wide sites of DNA damage caused by etoposide or nucleases, the distribution of double-strand breaks (DS […]
- GSE283398 Next Generation Sequencing of Wild Type and Asxl1; Vav-iCre Heterozygote HSCs August 27, 2025Contributors : Ali Abdelfattah ; Neil Rodrigues ; Peter GilesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusClinical GATA2 deficiency syndromes arise from germline haploinsufficiency inducing mutations in GATA2, resulting in immunodeficiency that evolves to myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML). H […]
- GSE306156 AoSho1 and AoOpy2 are involved in the regulation of mycelial growth, sporulation, osmoregulation, and pathogenicity in Arthrobotrys oligospora August 27, 2025Contributors : Xiaoli Li ; Jinkui Yang ; Lirong ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Orbilia oligosporaArthrobotrys oligospora, a widely distributed nematode-trapping fungus, utilises adhesive mycelial nets (traps) to capture nematodes. As key components of the MAPK cascade, Sho1 and Opy2 are critical in the fungal st […]