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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE262898 Single Cell Profiling in the Sox10Dom Hirschsprung Mouse Implicates Hox Genes in Enteric Neuron Trajectory Allocation August 25, 2025Contributors : Justin A Avila ; Joseph T Benthal ; Michelle Southard-SmithSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEnteric nervous system (ENS) development requires migration, proliferation, and neuronal diversification of progenitors to achieve normal gastrointestinal motility. Sox10 deficits disrupt the ratios […]
- GSE275042 3D genome architecture in MCF10A cells in repsonse to DNA damage and ER stress August 25, 2025Contributors : Baniulyte Gabriele ; Sammons A MorganSeries Type : OtherOrganism : Homo sapiensThe goal of this experiment was to assess changes in 3D chromatin structure in mammary gland epithelial cell line (MCF10A) response to chemical stimuli via etoposide (DNA damage) or tunicamycin (ER stress). Micro-C method with a comprehensive promoter capture panel […]
- GSE264569 Distinct roles for NFκB in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging August 25, 2025Contributors : Jennifer J Chia ; Apeksha Singh ; Alexander HoffmannSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHematopoietic aging is characterized by chronic inflammation associated with myeloid bias, HSC accumulation, and functional HSC impairment. Yet it remains unclear how inflammation promotes agi […]
- GSE276521 RNA sequencing in Saccharomyces cerevisiae with abrogated binding of Nab3 to PIC2 August 25, 2025Contributors : Sofia E Serna ; Sander GrannemanSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeWhole-transcriptome sequencing allowed us to compare transcriptomic differences between a Saccharomyces cerevisiae BY4741 parental strain (PIC2-GFP) and two derived mutants lacking Nab3 RNA-binding sites in PIC2. P […]
- GSE276081 Profiling of Oestrogen Regulated RNA Binding Protein Landscape Identifies a Role for FXR1 in Endocrine Resistance August 25, 2025Contributors : Yinzhong Shang ; Tao ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysregulated oestrogen signaling plays a critical role in the development of endocrine resistance and bone metastasis of ER+ breast cancer. Screening of estrogen-regulated RNA-binding proteins by using iTRAQ technology identified that […]
- GSE280208 A CDK11-dependent RNA polymerase II pause-release checkpoint precedes CDK9-mediated transition to transcriptional elongation [ChIP-Seq] August 25, 2025Contributor : Jennifer R DevlinSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensControlled gene expression is achieved through the intricate regulation of RNA polymerase II (Pol II) progression through transcription-cycle checkpoints. The pausing checkpoint, where Pol II temporarily stalls prior to […]
- GSE278922 Interplay between Genetic Variation and Nutrition Challenge Controls Hepatic Diurnal Rhythms [ChIA-PET] August 25, 2025Contributors : Zhou Dishu ; Chen Ying ; Liu Panpan ; Guan DongyinSeries Type : OtherOrganism : Mus musculusVariation in diurnal rhythms contributes to the risk of multiple diseases, yet the genomic and epigenomic basis remains largely unknown. Here, we show that SNPs in enhancer and promoter regions genome-wide contribute to variations in human diurnal rhyth […]
- GSE305947 Single-cell RNA and DNA methylome profiling reveal liquid helium vitrification enhances porcine parthenogenetically activated blastocyst viability [Bisulfite-Seq] August 25, 2025Contributors : Xueming Zhao ; Hongmei PanSeries Type : Methylation profiling by high throughput sequencingOrganism : Sus scrofaTranscriptome and methylation sequencing technologies were used to reveal the effects of vitrification on gene expression and genomic methylation levels in pig blastocysts.
- GSE305944 Single-cell RNA and DNA methylome profiling reveal liquid helium vitrification enhances porcine parthenogenetically activated blastocyst viability [RNA-Seq] August 25, 2025Contributors : Xueming Zhao ; Hongmei PanSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaTranscriptome and methylation sequencing technologies were used to reveal the effects of vitrification on gene expression and genomic methylation levels in pig blastocysts.
- GSE306006 Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis August 25, 2025Contributors : Endong Zhang ; Hanan Algarni ; Chih-Jia Chao ; Shan He ; Luyu Zhang ; Aditi Upadhye ; Qing Bao ; Dahee Jung ; Shubhi Srivastava ; Edidiong Udofa ; Philana Phan ; Steve Seung-Young Lee ; Jalees Rehman ; Zongmin ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMassive immune cell infiltration and persist […]
- GSE305992 Junction-binding–defective Cdc13 promotes adaptive mutation and transcriptomic rewiring under telomere stress August 25, 2025Contributor : Zhitong FengSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeTelomeres protect chromosome ends from degradation and inappropriate DNA repair. In budding yeast, the telomeric protein Cdc13 binds G-rich overhangs to maintain telomere integrity. Here, we show that Cdc13 also weakly interacts with a […]
- GSE306046 Decoding cellular stress states for toxicology using single-cell transcriptomics [scRNA-Seq] August 25, 2025Contributors : Brian N. Chorley ; Imran Shah ; Dennis J. EastburnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell transcriptomics (SCTr) offers a powerful platform for decoding the complexities of cellular stress responses to chemical exposures, capturing rare and transient subpopulations that can be obscured […]
- GSE306056 Epigenetic control and inheritance of rDNA arrays [1] August 25, 2025Contributors : Tamara Potapova ; Matthew Borchers ; Paxton Kostos ; Sean McKinney ; Jeff Haug ; Andrea Guarracino ; Steven Solar ; Madelaine Gogol ; Graciela Monfort Anez ; Leonardo Gomes de Lima ; Yan Wang ; Kate Hall ; Sophie Hoffman ; Erik Garrison ; Adam M Phillippy ; Jennifer L GertonSeries Type : Methylation profiling by high throughput sequencingOrgan […]
- GSE306059 Epigenetic control and inheritance of rDNA arrays [2] August 25, 2025Contributors : Tamara Potapova ; Matthew Borchers ; Paxton Kostos ; Sean McKinney ; Jeff Haug ; Andrea Guarracino ; Steven Solar ; Madelaine Gogol ; Graciela Monfort Anez ; Leonardo Gomes de Lima ; Yan Wang ; Kate Hall ; Sophie Hoffman ; Erik Garrison ; Adam M Phillippy ; Jennifer L GertonSeries Type : Methylation profiling by high throughput sequencingOrgan […]
- GSE212035 Differential N6-methyladenosine(m6A) modification in hypertrophic scar v.s. normal skin August 25, 2025Contributors : Xiaoxiao Liu ; Chunyan Guo ; Xiandong Lu ; Xiancai Li ; Shangfeng Fu ; Dewu LiuSeries Type : Methylation profiling by arrayOrganism : Homo sapiensN6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotes. Here, m6A-mRNA and lncRNA transcriptomes were profiled for HS and full-thickness normal skin (NS) tissues using hum […]