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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE276524 Mapping of Sen1 RNA-binding sites in Saccharomyces cerevisiae with abrogated binding of Nab3 to PIC2 August 25, 2025Contributors : Sofia E Serna ; Sander GrannemanSeries Type : OtherOrganism : Saccharomyces cerevisiaeUsing CRAC, we compared the transcriptomic occupancy of Sen1 in a Saccharomyces cerevisiae BY4741 parental strain (PIC2-GFP) and two derived mutants lacking Nab3 RNA-binding sites in PIC2. The purpose of the experiment was two-fold: on the one hand, we aimed […]
- GSE276519 Mapping of Nrd1 RNA-binding sites in Saccharomyces cerevisiae with abrogated binding of Nab3 to PIC2 August 25, 2025Contributors : Sofia E Serna ; Sander GrannemanSeries Type : OtherOrganism : Saccharomyces cerevisiaeUsing CRAC, we compared the transcriptomic occupancy of Nrd1 in a Saccharomyces cerevisiae BY4741 parental strain (PIC2-GFP) and two derived mutants lacking Nab3 RNA-binding sites in PIC2. The purpose of the experiment was two-fold: on the one hand, we aimed […]
- GSE280208 A CDK11-dependent RNA polymerase II pause-release checkpoint precedes CDK9-mediated transition to transcriptional elongation [ChIP-Seq] August 25, 2025Contributor : Jennifer R DevlinSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensControlled gene expression is achieved through the intricate regulation of RNA polymerase II (Pol II) progression through transcription-cycle checkpoints. The pausing checkpoint, where Pol II temporarily stalls prior to […]
- GSE280102 A CDK11-dependent RNA polymerase II pause-release checkpoint precedes CDK9-mediated transition to transcriptional elongation [RNA-seq] August 25, 2025Contributor : Jennifer R DevlinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensControlled gene expression is achieved through the intricate regulation of RNA polymerase II (Pol II) progression through transcription-cycle checkpoints. The pausing checkpoint, where Pol II temporarily stalls prior to release into transcrip […]
- GSE262898 Single Cell Profiling in the Sox10Dom Hirschsprung Mouse Implicates Hox Genes in Enteric Neuron Trajectory Allocation August 25, 2025Contributors : Justin A Avila ; Joseph T Benthal ; Michelle Southard-SmithSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEnteric nervous system (ENS) development requires migration, proliferation, and neuronal diversification of progenitors to achieve normal gastrointestinal motility. Sox10 deficits disrupt the ratios […]
- GSE156887 Impaired social cognition caused by perinatal protein malnutrition evokes psychiatric-like disorders and is intergenerationally transmitted. August 25, 2025Contributors : Estefanía A Fesser ; Octavio Gianatiempo ; Bruno G Berardino ; Nadina M Ferroni ; Maite Cambiasso ; Germán Falasco ; Vanina A Fontana ; Leandro Urrutia ; Silvina V Sonzogni ; Eduardo T CánepaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMaternal malnutrition remains one the major early-life adversities […]
- GSE305896 Selective targeting of HIV infected clones by cognate peptide stimulation and antiproliferative drugs August 25, 2025Contributors : Joel N Blankson ; Francesco R Simonetti ; Kellie N SmithSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensClonal expansion of HIV infected CD4+ T cells is a barrier to HIV eradication. We previously described a marked reduction in the frequency of the most clonally expanded infected CD4+ T cells in […]
- GSE275042 3D genome architecture in MCF10A cells in repsonse to DNA damage and ER stress August 25, 2025Contributors : Baniulyte Gabriele ; Sammons A MorganSeries Type : OtherOrganism : Homo sapiensThe goal of this experiment was to assess changes in 3D chromatin structure in mammary gland epithelial cell line (MCF10A) response to chemical stimuli via etoposide (DNA damage) or tunicamycin (ER stress). Micro-C method with a comprehensive promoter capture panel […]
- GSE305947 Single-cell RNA and DNA methylome profiling reveal liquid helium vitrification enhances porcine parthenogenetically activated blastocyst viability [Bisulfite-Seq] August 25, 2025Contributors : Xueming Zhao ; Hongmei PanSeries Type : Methylation profiling by high throughput sequencingOrganism : Sus scrofaTranscriptome and methylation sequencing technologies were used to reveal the effects of vitrification on gene expression and genomic methylation levels in pig blastocysts.
- GSE305944 Single-cell RNA and DNA methylome profiling reveal liquid helium vitrification enhances porcine parthenogenetically activated blastocyst viability [RNA-Seq] August 25, 2025Contributors : Xueming Zhao ; Hongmei PanSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaTranscriptome and methylation sequencing technologies were used to reveal the effects of vitrification on gene expression and genomic methylation levels in pig blastocysts.
- GSE305992 Junction-binding–defective Cdc13 promotes adaptive mutation and transcriptomic rewiring under telomere stress August 25, 2025Contributor : Zhitong FengSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeTelomeres protect chromosome ends from degradation and inappropriate DNA repair. In budding yeast, the telomeric protein Cdc13 binds G-rich overhangs to maintain telomere integrity. Here, we show that Cdc13 also weakly interacts with a […]
- GSE306006 Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis August 25, 2025Contributors : Endong Zhang ; Hanan Algarni ; Chih-Jia Chao ; Shan He ; Luyu Zhang ; Aditi Upadhye ; Qing Bao ; Dahee Jung ; Shubhi Srivastava ; Edidiong Udofa ; Philana Phan ; Steve Seung-Young Lee ; Jalees Rehman ; Zongmin ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMassive immune cell infiltration and persist […]
- GSE306046 Decoding cellular stress states for toxicology using single-cell transcriptomics [scRNA-Seq] August 25, 2025Contributors : Brian N. Chorley ; Imran Shah ; Dennis J. EastburnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell transcriptomics (SCTr) offers a powerful platform for decoding the complexities of cellular stress responses to chemical exposures, capturing rare and transient subpopulations that can be obscured […]
- GSE276254 A dual-mechanism antimicrobial peptide with antimutagenic activity targets the replisome and induces cell envelope stress August 25, 2025Contributors : Amanda Holstad Singleton ; Olaug E Torheim Bergum ; Jana Scheffold ; Synnøve Brandt Ræder ; Lilja Brekke Thorfinnsdottir ; Lisa M Røst ; Caroline Krogh Søgaard ; Per Bruheim ; Marit OtterleiSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliTo combat the growing threat of multidrug-resistant bacteria, we […]
- GSE305551 A Hedgehog-Induced Homeodomain Cascade Couples Progenitor Identity to Neuronal Diversification August 25, 2025Contributors : Chundi Xu ; Peter Newstein ; Chris DoeSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterHow progenitor identity instructs neuronal diversification remains unclear. We uncover a homeodomain transcription factor (HDTF) cascade that links the identity of a single lamina progenitor type to the divers […]