NCBI Insights

NCBI Insights

• Upcoming Changes to GenBank Project Lists and Symlinks August 20, 2025
  The volume of GenBank WGS, TSA, and TLS data sets is large and continues to grow rapidly. To help you identify and retrieve newly released data, we began providing symlinks and project list files in the Index of /genbank/daily-nc area approximately 12 years ago.  What’s new?  As the number of projects and files increases, the … Continue reading Upcoming Chan […]
  NCBI Staff
• PubMed Central (PMC) Beta Search to Replace Current Search August 19, 2025
  Coming the week of September 7th   The new PubMed Central (PMC) Beta search will replace the current PMC search the week of September 7, 2025.   As previously announced, the National Library of Medicine (NLM) National Center for Biotechnology Information (NCBI) is working on an update to PMC full-text search functionality and user experience. To … Continue r […]
  NCBI Staff
• Now Live: Improved Representation of Functional Data in ClinVar! August 18, 2025
  ClinVar is pleased to announce that our improved representation of functional data is live on the website, in file submissions, and in downloadable XML files. The following documentation is provided to facilitate future submissions and downloads: Instructions for submitting functional data in our Excel submission templates Updated submission templates Update […]
  NCBI Staff
• Now Available! NCBI Hidden Markov Models (HMM) Release 18.0 August 14, 2025
  Download release 18.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP). Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package.  What’s new?  Release 18.0 contains:  18,057 HMMs maintained by NCBI  631 new HMMs sinc […]
  NCBI Staff
• Coming Soon: ClinVar Search Enhancements July 22, 2025
  As previously announced, NCBI is improving the ClinVar homepage to serve as a better introduction to data and services within the resource. We are also enhancing your search experience in ClinVar!   Search enhancements  We are introducing a multiple box search interface where you can enter one or more terms. Each box will be labeled … Continue reading Coming […]
  NCBI Staff
• Improved Gene Data Access with Redesigned NCBI Gene Pages July 14, 2025
  We are excited to announce redesigned NCBI Gene pages! The redesigned pages (available through NCBI Datasets) offer a modern, clean interface with an intuitive layout that makes browsing and downloading NCBI Gene data easier. The legacy Gene page will continue to be available during this transition period, and we will continue to communicate updates and … Co […]
  NCBI Staff
• NCBI Website Maintenance — Beginning July 25th July 8, 2025
  On Friday, July 25th, starting at 9:00 PM EDT, we’ll be performing essential maintenance on the NLM data center. This upgrade is critical to ensure the continued reliability and stability of our services. We anticipate this planned outage will last 24 hours or more. During this time, users may experience interrupted access or degraded performance … Continue […]
  NCBI Staff
• Updates to Offerings in Support of the 2024 NIH Public Access Policy July 2, 2025
  The National Center for Biotechnology Information (NCBI) at the National Library of Medicine (NLM) has made initial updates to several offerings to support NIH-funded researchers and institutions to comply with the 2024 NIH Public Access Policy, which went into effect July 1, 2025. NCBI will continue to make ongoing improvements over the coming months.   … C […]
  NCBI Staff
• Compare Nucleotide Differences in the Multiple Comparative Genome Viewer (MCGV)! June 18, 2025
  NCBI’s new Multiple Comparative Genome Viewer (MCGV) is an interactive graphical genome browser that allows you to visualize multiple genome assemblies in a single view. MCGV displays whole genome alignments created by the research community.  What’s new? We made several significant updates to this application since its initial release last winter! Now you c […]
  NCBI Staff
• Genetic Testing Registry (GTR®) Search Improvements June 12, 2025
  We are excited to announce an improved search and navigation experience in the NIH Genetic Testing Registry (GTR®) so you can find the tests you need in a more intuitive and powerful way. Try searching GTR on our new Beta site and let us know how we can improve!   What’s new?  1. One search box for … Continue reading Genetic Testing Registry (GTR®) Search Im […]
  NCBI Staff