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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE273483 Systems approach identifies monocyte imbalance in symptomatic and asymptomatic P. vivax malaria August 20, 2025Contributors : Stephanie I Studniberg ; Diana S Hansen ; Alexandra GarnhamSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlthough asymptomatic malaria was historically perceived as innocuous, emerging evidence revealed an immunosuppressive signature induced by asymptomatic Plasmodium falciparum infections. To examine i […]
- GSE278151 Synergistic Exacerbation of Oral Streptococci-induced pneumonia due to Prevotella intermedia August 20, 2025Contributors : Naoki Iwanaga ; Hiroki AshizawaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAnaerobic bacteria in the oral cavity can cause respiratory infections. However, their precise mechanisms of action remain elusive. Unexpectedly, bacterial flora analysis using 16s rRNA revealed ‘hidden’ mixed infections of ana […]
- GSE275625 Whole transcriptome analysis of control human fibroblasts, TGFβ-induced human fibroblasts, and fibroblasts co-cultured with normal lung decellularized scaffolds and fibroblasts co-cultured with bleomycin-induced lung decellularized scaffolds. August 20, 2025Contributors : Chan Chen ; Zhiyi Wang ; Jingwen Yang ; Peisen ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFibrosis refers to the abnormal proliferation and excessive accumulation of fibrous tissue in an organ or tissue, typically caused by chronic injury or inflammation. Fibroblasts play a crucial role in the in […]
- GSE283992 CFTR gene regulation in pancreatic duct, bile duct and sweat gland August 20, 2025Contributors : Ayushi Umrigar ; Katreya Lovrenert ; Jenny L Kerschner ; Shih-Hsing Leir ; Ann HarrisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe examine cis-regulatory elements controlling expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in ductal eptihelial cells fro […]
- GSE280582 Escalated oxycodone self-administration is associated with activation of specific gene networks in the rat dorsal striatum August 20, 2025Contributors : Ammanuel Y Wabreha ; Atul P Daiwile ; Michael T McCoy ; Jean Lud CadetSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThe number of individuals diagnosed with opioid use disorder (OUD) has risen steeply because of the increased prescribing of opioid drugs like oxycodone for chronic pain relief. OUD i […]
- GSE305789 Activation of OSM-STAT3 Epigenetically Regulates Tumor-Promoting Transcriptional Programs in Cervical Cancer [RNA-Seq] August 20, 2025Contributors : Junho Noh ; Chaelin You ; Keunsoo Kang ; Kyuho KangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite improvements in preventative strategies, such as regular screenings with Pap tests and human papillomavirus (HPV) tests as well as HPV vaccinations, effective treatment for advanced cervical cancer r […]
- GSE288162 SPATIAL TRANSCRIPTOMICS IDENTIFY HOMOLOGOUS MECHANISMS IN THE PATHOPHYSIOLOGY OF HUMAN AND E4FAD MOUSE CEREBRAL MICROBLEEDS August 20, 2025Contributors : Abhinav Srinath ; Diana Vera Cruz ; Dorothy DeBiase ; Akash Bindal ; Ying Li ; Geetha P Yeradoddi ; Mannan Bhola ; Rhonda Lightle ; Justine Lee ; Agnieszka Stadnik ; Kristina Piedad ; Robert Shenkar ; Peter Pytel ; Yuanyuan Zhu ; Sharbel Romanos ; Thomas Moore ; Sean Polster ; Yuan Li ; Xiaoxi Zhuang ; Christopher Gomez ; Sangram Sisodia ; Rom […]
- GSE305592 Transcriptomic Analysis Reveals TME-Mediated Macrophage IFIT1 Upregulation and CX3CR1 Suppression Drive Osteosarcoma Progression August 20, 2025Contributors : Keyi Wang ; Huanyang He ; Jiamin Liang ; Yuangang Su ; Jinmin Zhao ; Qian LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOsteosarcoma (OS) is one of the most common bone tumors which prognosis of patients is unsatisfactory. Due to the stagnancy in conventional treatments, researchers begin to find the […]
- GSE305582 ProCTLA-4 in anti-tumor immunity August 20, 2025Contributors : Weian Cao ; Junfan Chen ; Yutong Fu ; Wenyan Wang ; Yang-Xin FuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe developed a prodrug of the anti-CTLA4 antibody, named ProCTLA-4. ProCTLA-4 elicits anti-tumor immune responses with reduced toxicity compared to current CTLA4 blockade therapies. Moreover, com […]
- GSE305619 Repeats Mimic Pathogen-Associated Patterns Across a Vast Evolutionary Landscape [J2-RIP-Seq] August 20, 2025Contributors : Daniel De Carvalho ; Håvard Lindholm ; Sajid Marhon ; Amir Hosseini ; Raymond Chen ; Benjamin Greenbaum ; Siyu SunSeries Type : OtherOrganism : Homo sapiensAn emerging hallmark of many human diseases is transcription of typically silenced repetitive DNA containing pathogen-associated molecular patterns (PAMPs). These PAMPs engage the innate im […]
- GSE305618 Repeats Mimic Pathogen-Associated Patterns Across a Vast Evolutionary Landscape [RIP-Seq] August 20, 2025Contributors : John LaCava ; Siyu SunSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensAn emerging hallmark of many human diseases is transcription of typically silenced repetitive DNA containing pathogen-associated molecular patterns (PAMPs). These PAMPs engage the innate immune system via pattern recognition rec […]
- GSE305700 Single-Cell RNA-Seq Study Showing the Effect of Healthy and Cencer Cells on HSCs August 20, 2025Contributors : Reza Shahbazi ; Samaneh Maleknia ; Sanam Rezaei BenamSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHematopoietic stem cells (HSCs) are highly sensitive to signals from their surrounding microenvironment, yet the precise effects of healthy versus malignant cells on HSC behavior remain poorly understood. […]
- GSE305760 Exploring the Differential Host Responses to DSS and UC-Derived Microbiota in a Mouse Model of Colitis August 20, 2025Contributors : Maria Rynikova ; Sona Gancarcikova ; Stanislav Lauko ; Dagmar Mudronova ; Petra Adamkova ; Martin Janicko ; Vlasta DemeckovaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUlcerative colitis (UC) is a chronic inflammatory condition of the colon, characterized by recurring mucosal inflammation. Current evi […]
- GSE305788 Activation of OSM-STAT3 Epigenetically Regulates Tumor-Promoting Transcriptional Programs in Cervical Cancer [ATAC-Seq] August 20, 2025Contributors : Junho Noh ; Chaelin You ; Keunsoo Kang ; Kyuho KangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDespite improvements in preventative strategies, such as regular screenings with Pap tests and human papillomavirus (HPV) tests as well as HPV vaccinations, effective treatment for advanced cer […]
- GSE262450 Adenosine Kinase and ADAL Coordinate Detoxification of Modified Adenosines to Safeguard Metabolism August 20, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA contains diverse post-transcriptional modifications, and its catabolic breakdown yields numerous modified nucleosides requiring correct processing, but the mechanisms remain unknown. Here, we demonstrate that three RNA-derived modified adenosines, N6-methyladenosine (m […]