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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE275467 CD45+ Epcam- poluation scRNAseq analysis in control and Goblet-Y/T-Scgb1a1CreERT mouse lung tissues. August 20, 2025Contributors : Nan Cheng ; Xaralabos VarelasSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe gole of this experiment is to get an in depth understanding of the immune population responses in mouse lungs presented with goblet cell metaplasia in the airway upon Yap/Taz deletion in Scgb1a1+ cells.
- GSE275325 FUS controls muscle differentiation and structure through LLPS mediated recruitment of MEF2 and ETV5 [RNA-Seq] August 20, 2025Contributors : Gina Picchiarelli ; Anne Zienand ; Salim Megat ; Amr Aly ; Marije Been ; Saskia Hutten ; Erin Sternburg ; Pierre Cauchy ; Stéphane Dieterle ; Marica Catinozzi ; Valérie Demais ; Laura Tzeplaeff ; Anne M Huebers ; Dagmar Zeuschner ; Albert C Ludoplh ; Anne-Laurence Boutilier ; Tobias Boesckers ; Dorothee Dormann ; Maria Demestre ; Chantal Selli […]
- GSE289448 DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights [CUT&RUN] August 20, 2025Contributors : Huating Wang ; Xiaona Chen ; Feng Yang ; Suyang ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusDNA G-quadruplexes (G4s) are non-canonical secondary structures formed in Guanine-rich DNA sequences and recent studies demonstrate G4s play important roles in modulating multi […]
- GSE289445 DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights [RNA-seq] August 20, 2025Contributors : Huating Wang ; Xiaona Chen ; Feng Yang ; Suyang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusDNA G-quadruplexes (G4s) are non-canonical secondary structures formed in Guanine-rich DNA sequences and recent studies demonstrate G4s play important roles in modulating multiple biological […]
- GSE298910 Pathologic TPO-induced TPOR-CSF2RB signaling mediates Down syndrome abnormal myelopoiesis due to GATA1 mutant-dependent CSF2RB overexpression [CUT&Tag] August 20, 2025Contributor : David Cruz HernandezSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTransient abnormal myelopoiesis (TAM) is a human myeloid leukemia that occurs in newborns with Trisomy 21, who acquire mutations in the transcription factor GATA1. TAM originates in the fetal liver but spontaneously regresses […]
- GSE290534 Integration of CRISPR-Cas9 Screens and Multi-Omics Profiling Reveals CHD7-ANGPT1 as a Novel Multi-Drug Resistance Axis in AML August 20, 2025Contributor : Dandan YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore how the loss of function of CHD7 leads to drug resistance in acute myeloid leukemia (AML) cells, we investigated the transcriptional programs regulated by CHD7 in OCI-AML2 cells under different drug treatment conditions. This study aims […]
- GSE305582 ProCTLA-4 in anti-tumor immunity August 20, 2025Contributors : Weian Cao ; Junfan Chen ; Yutong Fu ; Wenyan Wang ; Yang-Xin FuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe developed a prodrug of the anti-CTLA4 antibody, named ProCTLA-4. ProCTLA-4 elicits anti-tumor immune responses with reduced toxicity compared to current CTLA4 blockade therapies. Moreover, com […]
- GSE254972 JPF promotes repair of early nontraumatic osteonecrosis of the femoral head by inhibiting NAMPT/STK11/HMGCR/ACAT1 signal axis-mediated lipid production August 20, 2025Contributors : Tao Li ; Zhaochen Ma ; Xueting Liu ; Chu ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensJianpi Huogu Formula (JPF) has achieved good curative effects in nontraumatic osteonecrosis of the femoral head (NONFH) in clinical practice. However, its underlying pharmacological mechanisms remain unclear. Her […]
- GSE305618 Repeats Mimic Pathogen-Associated Patterns Across a Vast Evolutionary Landscape [RIP-Seq] August 20, 2025Contributors : John LaCava ; Siyu SunSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensAn emerging hallmark of many human diseases is transcription of typically silenced repetitive DNA containing pathogen-associated molecular patterns (PAMPs). These PAMPs engage the innate immune system via pattern recognition rec […]
- GSE305592 Transcriptomic Analysis Reveals TME-Mediated Macrophage IFIT1 Upregulation and CX3CR1 Suppression Drive Osteosarcoma Progression August 20, 2025Contributors : Keyi Wang ; Huanyang He ; Jiamin Liang ; Yuangang Su ; Jinmin Zhao ; Qian LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOsteosarcoma (OS) is one of the most common bone tumors which prognosis of patients is unsatisfactory. Due to the stagnancy in conventional treatments, researchers begin to find the […]
- GSE305619 Repeats Mimic Pathogen-Associated Patterns Across a Vast Evolutionary Landscape [J2-RIP-Seq] August 20, 2025Contributors : Daniel De Carvalho ; Håvard Lindholm ; Sajid Marhon ; Amir Hosseini ; Raymond Chen ; Benjamin Greenbaum ; Siyu SunSeries Type : OtherOrganism : Homo sapiensAn emerging hallmark of many human diseases is transcription of typically silenced repetitive DNA containing pathogen-associated molecular patterns (PAMPs). These PAMPs engage the innate im […]
- GSE305700 Single-Cell RNA-Seq Study Showing the Effect of Healthy and Cencer Cells on HSCs August 20, 2025Contributors : Reza Shahbazi ; Samaneh Maleknia ; Sanam Rezaei BenamSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHematopoietic stem cells (HSCs) are highly sensitive to signals from their surrounding microenvironment, yet the precise effects of healthy versus malignant cells on HSC behavior remain poorly understood. […]
- GSE305760 Exploring the Differential Host Responses to DSS and UC-Derived Microbiota in a Mouse Model of Colitis August 20, 2025Contributors : Maria Rynikova ; Sona Gancarcikova ; Stanislav Lauko ; Dagmar Mudronova ; Petra Adamkova ; Martin Janicko ; Vlasta DemeckovaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUlcerative colitis (UC) is a chronic inflammatory condition of the colon, characterized by recurring mucosal inflammation. Current evi […]
- GSE274895 An aberrant resurrection of endogenous retrovirus prompts acute myocarditis and heart failure August 20, 2025Contributors : Junhao Xiong ; Bing Zhang ; Zilong GengSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Mus musculusThe abberant resurgence of which have been recently found to link to some critical pathologies. To […]
- GSE305564 Stress-Induced Iron-Sulfur Cluster Damage as a Conserved Trigger of the Stringent Response August 20, 2025Contributors : Eva Michaud ; Lorena Ricci ; Claire Lallement ; Lars Barquist ; Vincent Cattoir ; Charlotte Michaux ; Régis Hallez ; Severin RonneauSeries Type : Expression profiling by high throughput sequencingOrganism : Salmonella enterica subsp. enterica serovar TyphimuriumPathogenic bacteria rely on the stringent response to adapt to hostile environments […]