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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE274685 Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth August 9, 2025Contributors : Victor Fattori ; Michael S RogersSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEndometriosis is a debilitating and painful gynecological inflammatory disease affecting approximately 15% of women. Current treatments are ineffective for a significant fraction of patients, underscoring the need for new med […]
- GSE274886 Characterization of DNA methylation and transcriptomics during early pregnancy in dairy cows [RNA-seq] August 9, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Bos taurusDNA methylation is an essential epigenetic mechanism involved in cell differentiation, proliferation, apoptosis, and metabolism. However, the DNA methylation changes of related genes during early pregnancy in dairy cows remain unclear . The purpose of this study was to study […]
- GSE274885 Characterization of DNA methylation and transcriptomics during early pregnancy in dairy cows August 9, 2025Series Type : Methylation profiling by high throughput sequencingOrganism : Bos taurusDNA methylation is an essential epigenetic mechanism involved in cell differentiation, proliferation, apoptosis, and metabolism. However, the DNA methylation changes of related genes during early pregnancy in dairy cows remain unclear . The purpose of this study was to stud […]
- GSE276001 mRNA Sequencing Analysis of MCM7 Knockdown in Primary Hepatocytes Under IL-6 Stimulation August 9, 2025Contributors : R Zhou ; C WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLiver fibrosis, marked by excessive extracellular matrix deposition, remains a significant challenge due to its complex and not fully understood mechanisms. This study explores the role of Minichromosome Maintenance Complex Component 7 (MCM7) […]
- GSE275059 High-throughput mRNA-sequence of MCM7 and SHCBP1 knock down hepatocytes with IL-1β stimulation August 9, 2025Contributors : R Zhou ; C WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLiver fibrosis, characterized by the excessive deposition of extracellular matrix, remains a formidable challenge due to its complex and poorly understood mechanisms. In this study, we aimed to elucidate the role of Minichromosome Maintenance […]
- GSE305000 Human cytomegalovirus infection impairs axon formation via repressing glycogen synthase kinase-3β activity-mediated adenosine triphosphate synthesis August 9, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman cytomegalovirus (HCMV)has a global distribution and is highly prevalent. HCMV infection has been recognized as a major contributor to neural development abnormalities in embryos and children. However, the underlying mechanisms by which HCMV infection leads to neurolo […]
- GSE277941 Aurora A Regulates the Material Property of Spindle Poles to Orchestrate Nuclear Organization at Mitotic Exit August 9, 2025Contributors : François Charon ; Daan NoordermeerSeries Type : OtherOrganism : Homo sapiensAnimal cells dismantle their nuclear envelope (NE) at the beginning and reconstruct it at the end of mitosis. This process is closely coordinated with spindle pole organization: poles enlarge at mitotic onset and reduce in size as mitosis concludes. The significance of […]
- GSE296358 ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells [bulk RNA-seq] August 9, 2025Contributors : Martina Pigoni ; Roberto Villasenor Solorio ; Lia D'AbateSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransferrin receptor in brain endothelial cells can deliver therapeutic antibodies to the brain via transcytosis across the blood-brain barrier. Whether receptor transport remains intact in Alzhei […]
- GSE286017 RNA and PTBP1-RIP sequencing in BEAS-2B cells with circFCHO2 overexpression and knockdown August 9, 2025Contributors : Yucong Wang ; Yanfei Liu ; Dahai ZhaoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCircular RNAs (circRNAs) have emerged as key regulators in human diseases, yet their mechanisms of action in chronic obstructive pulmonary disease (COPD) remain largely unknown. We report a mammalian conserved cir […]
- GSE303131 Pancreatic cancer-intrinsic HuR regulates the pro-tumorigenic properties of extracellular vesicles August 9, 2025Contributors : Jennifer M Finan ; Matthew Ryer ; Kevin Hawthorne ; Rosalie C Sears ; Jonathan R BrodySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) tumors contain chaotic vasculature that limits immune surveillance and promotes early events in the metastatic cascade. However, cur […]
- GSE298797 Medium-chain triglycerides improve cognition and systemic metabolism in Alzheimer mice August 9, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE304505 CD200R1 loss in CNS-associated macrophages triggers T cell-driven neurodegeneration in Parkinson’s disease August 9, 2025Contributors : Ting Zhang ; Zhen Zhang ; Kun Niu ; Taoying Huang ; Jiali Guo ; Xiaoli Gong ; Yunke Gao ; Qixin Zhu ; Ang Zhao ; Gongbikai Xarbat ; Yuheng Liu ; Jie Shen ; Xiannian Zhang ; Jun Jia ; Ke Wang ; Shuying Liu ; Zhaoyuan Liu ; Florent GinhouxSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune dysregulation […]
- GSE304525 Conserved facultative heterochromatin across cell types identify regulatory sequences underpinning cell identity and disease August 9, 2025Contributors : Enakshi Sinniah ; Dalia Mizikovsky ; Woo Jun Shim ; Chris Chow ; Yassine Souilmi ; Fei-Fei Cheng ; Zhili Zeng ; Jordan Laurie ; Matthew Foster ; Sonia Shah ; Mikael Boden ; Jian Zeng ; Bastien Llamas ; Nathan J PalpantSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCellular diversity is a product of evolu […]
- GSE304623 Spermatogenesis, hormonal fluctuations, and testicular gene expression changes in male blue catfish, Ictalurus furcatus, throughout pubescent and early adult stages of development August 9, 2025Contributors : Ian Butts ; Jason Abernathy ; Kaylan MartinSeries Type : Expression profiling by high throughput sequencingOrganism : Ictalurus furcatusMale blue catfish (Ictalurus furcatus) mature at 4-7 years and cannot be hand-stripped, making sperm collection a lethal procedure. Sperm are also highly variable in quality/quantity. Therefore, establishing l […]
- GSE274520 PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma August 9, 2025Contributors : Voss Dillon ; Krainer AdrianSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPyruvate kinase M isoform 2 (PKM2) is preferentially expressed in nearly all cancers. It primarily functions as the last enzyme in glycolysis, but has other reported non-canonical functions, including recruiting transcription fact […]