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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE250497 One-step generation of modified cattle and sheep from spermatid-like haploid stem cells August 2, 2025Series Type : Methylation profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; OtherOrganism : Bos taurus ; Ovis ariesThis SuperSeries is composed of the SubSeries listed below.
- GSE211924 UCHL5 promotes Tumorigenesis of Bladder Cancer by Activating AKT/mTOR signaling pathway and targeting c-myc, SLC25A19, and ICAM5. August 2, 2025Contributors : Yuanfei Cao ; Hua Yu ; Tao Liu ; Tongzu LIIuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: To investigate the tumor-promoting role of UCHL5 in bladder cancer.Method: We established the UCHL5 knockdown cell line in which the target gene was knocked down by shRNA. RNA was extracted from cells usin […]
- GSE273932 Staphylococcus aureus delays wound repair by harnessing the agr quorum sensing system to target keratinocyte lipid metabolism [scRNA-seq] August 2, 2025Contributor : Michelle D BagoodSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe used single cell sequencing to examine the response of murine dorsal skin and periwound tissue to vehicle, wild type S. aureus, or S. aureus agr mutant.
- GSE273931 Staphylococcus aureus delays wound repair by harnessing the agr quorum sensing system to target keratinocyte lipid metabolism [Spatial Transcriptomics] August 2, 2025Contributor : Michelle D BagoodSeries Type : OtherOrganism : Mus musculusWe performed spatial transcriptomics to characterize wound tissue response to commensal and pathogenic staphylococcus strains. Our analysis has revealed unique epithelial responses to each strain.
- GSE275579 NagA deletion of Mycobacterium tuberculosis leads to a defective cell wall integrity and invokes unique host signatures rendering the pathogen attenuated in guinea pigs. August 2, 2025Contributors : Neha L Nagpal ; Prachi Nangpal ; Madavan Vasudevan ; Garima KhareSeries Type : Expression profiling by high throughput sequencingOrganism : Cavia porcellusMtb N-acetylglucosamine-6-phosphate deacetylase (NagA, Rv3332) belonging to the amido-hydrolase superfamily catalyzes a reaction which generates vital amino-sugars required as precursors for […]
- GSE273933 Staphylococcus aureus delays wound repair by harnessing the agr quorum sensing system to target keratinocyte lipid metabolism [bulkRNA-seq] August 2, 2025Contributor : Michelle D BagoodSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNHEKs wounded by scratch and incubated with CM for 24 hours were evaluated by bulk RNAseq. Principal component analysis of these data revealed wounded NHEKs exposed to S. hominis products clustered close to control keratinocytes, suggesting t […]
- GSE280151 ARD1 facilitates ferroptosis evasion via the induction of glutathione synthesis through catalysis of PABPC1 acetylation in HCC [CRISPR screen] August 2, 2025Contributors : Yingyi Liu ; MInghe Zhang ; Yufeng YuanSeries Type : OtherOrganism : synthetic constructAberrant upregulation of intracellular antioxidant glutathione (GSH) is implicated in promoting tumor proliferation, inducing drug resistance, and inhibiting ferroptosis across various malignancies, including hepatocellular carcinoma (HCC). However, the mec […]
- GSE279888 ARD1 facilitates ferroptosis evasion via the induction of glutathione synthesis through catalysis of PABPC1 acetylation in HCC August 2, 2025Contributors : Yingyi Liu ; MInghe Zhang ; Yufeng YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAberrant upregulation of intracellular antioxidant glutathione (GSH) is implicated in promoting tumor proliferation, inducing drug resistance, and inhibiting ferroptosis across various malignancies, including hepatocell […]
- GSE291066 Transcriptional profiling of brown preadipocytes with Low or High adipogenic potential August 2, 2025Contributors : Mathieu Laplante ; Charles Colas ; Blandine Secco ; Mathilde Mouchiroud ; Romain Villot ; Laurence Belley ; Alona Kolnohuz ; Bochra Chadel ; Yves Gélinas ; Mathieu C Morissette ; Nolwenn Samson ; Audrey Poirier ; Laura Tribouillard ; Alyson Dufour ; Manal Al DowSeries Type : Expression profiling by arrayOrganism : Mus musculusBrown adipose tis […]
- GSE288059 CFP1 promotes germinal center affinity maturation and restrains and memory B cell differentiation through H3K4me3 modulation August 2, 2025Contributors : Yanan Zhao ; Shuoxu Gong ; Yaling Yang ; Jingning Bai ; Yimiao Lu ; Meiling Liu ; Wanyu Bai ; Junchao DongSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusAffinity maturation and differentiation of B cells in the germinal center (GC) are ti […]
- GSE301304 The Acetyltransferase ARD1 Induces Glutathione Synthesis to Facilitate Ferroptosis Evasion in Hepatocellular Carcinoma August 2, 2025Contributors : Yingyi Liu ; Yufeng YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAberrant upregulation of the intracellular antioxidant glutathione (GSH) is implicated in promoting tumor proliferation, inducing drug resistance, and inhibiting ferroptosis across various malignancies, including hepatocellular carcin […]
- GSE303873 Differential gene expression in human keratinocytes cultured on different substrate topographies (S1 and S2) for 1h, 4h and 12h. August 2, 2025Contributors : Sebastiaan Zijl ; Toru Hiratsuka ; Atefeh Mobasseri ; Mirsana Ebrahimkutty ; Mandy Börmel ; Sergi Garcia-Manyes ; Fiona M. WattSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSubstrate topography has emerged as a novel regulator of cell fate behaviour in keratinocytes (Zijl, Acta Biomater, 2019). Specific […]
- GSE304329 RNA sequencing of 4N intestinal and non-intestinal C. elegans cells in L1 August 2, 2025Contributors : Ramon Barrull-Mascaró ; Sonia Veltkamp ; Samia Boutaibi ; Lotte M van Rijnberk ; Rebecca Lippmann ; Matilde GalliSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansEndomitosis is a non-canonical cell cycle in which cells undergo all four phases of a canonical cell cycle (G1, S, G2 and M), but do no […]
- GSE304344 ChICseq analysis of active and repressive histone modifications in intestinal and non-intestinal C. elegans cells [ChIC-seq] August 2, 2025Contributors : Ramon Barrull-Mascaró ; Sonia Veltkamp ; Samia Boutaibi ; Lotte M van Rijnberk ; Rebecca Lippmann ; Matilde GalliSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Caenorhabditis elegansEndomitosis is a non-canonical cell cycle in which cells undergo all four phases of a canonical cell cycle (G1, S, G2 and […]
- GSE304347 Disruption of the Placenta-Brain Axis in Transgenic Mice Lacking Serotonin Transporter (SERT) in Trophoblast Cell August 2, 2025Contributors : David T Ellenberger ; Zhen Lyu ; Rosalind Herrington ; Jessica A Kinkade ; Gustavo W Leone ; Ji Ying Sze ; Nathan J Bivens ; Robert F Baker ; Michael R Roberts ; Trupti Joshi ; Cheryl S RosenfeldSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSelective serotonin reuptake inhibitors (SSRIs) are commonly pr […]