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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE209719 H9c2 cells with or without lactate July 25, 2025Contributors : Ahmad A Cluntun ; Jordan A Berg ; Zsanett Buko ; Jared RutterSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusH9c2 cardiomyoblast cells grown in DMEM or HPLM in the presence and absence of lactate. 4 unique conditions.
- GSE303685 Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity July 25, 2025Contributors : Tyler R Colson ; James J Cameron ; Hayley I Muendlein ; Mei-An Nolan ; Jamie L Leiriao ; James H Kim ; Alexander N Poltorak ; Xudong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusReprogramming autoreactive CD4⁺ effector T (Teff) cells into immunosuppressive regulatory T (Treg) cells represents a promi […]
- GSE272376 A dual TGF-β-driven immunosuppressive mechanism controls T cell recruitment and expansion in metastatic colorectal cancer July 25, 2025Contributors : Ana Henriques ; Maria Salvany ; Paula Nieto ; Sergio Palomo-Ponce ; Marta Sevillano ; Xavier Hernando-Momblona ; Emily Middendorp-Guerra ; Sebastien Tosi ; Theresa Suckert ; Adria Caballé ; Lidia Mateo ; Daniele Tauriello ; Elena Sancho ; Camille Stephan-Otto Attolini ; Alejandro Prados ; Holger Heyn ; Eduard BatlleSeries Type : Expression pro […]
- GSE262675 Enhanced Media Optimize Bovine Myogenesis in 2D and 3D Models for Cultivated Meat Applications [RNA-Seq] July 25, 2025Contributors : Christine L Li Trautmann ; Adhideb Ghosh ; Falko Noé ; Ori Bar-NurSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusLivestock farming and conventional meat production pose significant environmental, health, and animal welfare challenges. In seeking sustainable alternative solutions, cultivated meat technology […]
- GSE273690 Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s disease July 25, 2025Contributors : Beika Zhu ; Andi Wangzhou ; Diankun Yu ; Tao Li ; Rachael Schmidt ; Stacy L De Florencio ; Lauren Chao ; Yonatan Perez ; Lea T Grinberg ; Salvatore Spina ; Arnold R Kriegstein ; William W Seeley ; Richard M Ransohoff ; Tomasz Nowakowski ; Xianhua PiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicrogl […]
- GSE273123 Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling (Bulk RNA-Seq) July 25, 2025Contributors : Evan T Hoffman ; Willy Roque Barboza ; Luis R Rodriguez ; Rachna Dherwani ; Kasey Minakin ; Yaniv Tomer ; Dakota Jones ; Aditi Murthy ; Adam Bennett ; Ana Nottingham ; Pushpinder S Bawa ; Feiya Wang ; Apoorva Babu ; Katrina Chavez ; Charlotte H Cooper ; Maria C Basil ; Micha S Brickman Raredon ; Darrell N Kotton ; Konstantinos-Dionysios Alysan […]
- GSE303458 Downregulation of NF-κB and NLRP3 in aging wildtype and amyloid β transgenic mice July 25, 2025Contributors : Cali M McEntee ; Devin Wahl ; Thomas J LaRoccaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuroinflammation is a key component of Alzheimer's disease (AD), and it may be driven by the activation of NFκB and NLRP3 signaling pathways. AD pathology, like amyloid-β, may exacerbate the activation of t […]
- GSE277861 Enalapril mitigates senescence and aging-related phenotypes by targeting antioxidative genes via phosphorylated Smad1/5/9 [RNA-seq] July 25, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusAging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study, we […]
- GSE303616 cGAS-STING activation promotes innate and adaptive immunity crosstalk and enhances anti-tumor response July 25, 2025Contributor : Zhichao(Eric) AiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe cancer-immunity cycle is regulated by a series of stimulatory and inhibitory factors. The Stimulator of Interferon Genes (STING) pathway, a key stimulator of type I interferon production, bridges innate and adaptive immunity to promote ant […]
- GSE303539 Immune Landscape of RA from Synovial Biopsy Before and After DMARD Treatment July 25, 2025Contributors : Deborah R Winter ; Harris PerlmanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensSynovial biopsy was performed on RA patients with active synovitis prior to starting a new DMARD treatment and 6 weeks following.
- GSE303619 mRNA sequencing of human AC16 cells expressing PCBP1, PCBP2, or both July 25, 2025Contributors : Maggie P Lam ; Shaonil Binti ; Edward LauSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore potential functional implications of isoform usage shifts, we examined the effect of PCBP1/PCBP2 expression in human AC16 cardiac cells. PCBP1/PCBP2 are KH-domain-containing RNA-binding proteins (RBP) that […]
- GSE303622 Expression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth July 25, 2025Contributors : Surajit Sinha ; Vishal Koparde ; Jonathan HernandezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo form overt metastases, disseminated tumor cells must simultaneously acquire nutrients, circumvent oxidative stress, and evade organ-specific innate immune surveillance upon arrival. Given the propensity o […]
- GSE303645 IFNG production by self-reactive CD4 T cells drives the adrenal autoimmune pathology in the mouse model of Addison’s disease July 25, 2025Contributors : Arina Andreyeva ; Juraj Michalik ; Veronika Cimermanova ; Veronika Niederlova ; Ondrej Stepanek ; Ales NeuwirthSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusAutoimmune Addison’s disease (AD) is a rare, life-threatening endocrine disorder caused by immune-mediated destruction of the adrenal corte […]
- GSE282308 Gene expression profiles of brain injury at single cell level from aged mice treated with or without microglial replacement July 25, 2025Contributors : Xiao-Yi Xiong ; Peng-Fei WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe used single cell RNA sequencing (scRNA-seq) to analysis the gene expression profile of myeloid cells of brain injury influenced by microglial replacement in aged mice.
- GSE303455 Identification of double-stranded RNAs modulated by ADAR1 July 25, 2025Contributors : Cali M McEntee ; Thomas J LaRoccaSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensEndogenous double-stranded RNA (dsRNA) triggers pro-inflammatory signaling and has been shown to accumulate in Alzheimer’s disease (AD), but the origins of this dsRNA are incompletely understood. Transposable elements […]