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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE266188 Profiling of gene expression, histone marks, chromatin accessibility, and DNA methylation in myeloid progenitors expressing H3WT, H3K4M, H3K27M, or H3K4M/K27M for 2 weeks [CUT&Tag] July 17, 2025Contributors : Masaki Yagi ; Gracia Bonilla ; Ruslan Sadreyev ; Konrad HochedlingerSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDevelopmental gene expression is tightly regulated by the dynamic interplay of H3K4 and H3K27 methylation associated with active and repressed genes, respectively. Howe […]
- GSE274146 Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation July 17, 2025Contributors : Ana L Dian ; Lucilla Fabbri ; Antoine Moya-Plana ; Giuseppina Claps ; Juliana C Ferreira ; Céline M Labbé ; Virginie Quidville ; Sylvain Martineau ; Dorothée Baille ; Laetitia Besse ; Cédric Messaoudi ; Séverine Roy ; Virginie Raynal ; Sylvain Baulande ; Wael M Rabeh ; Caroline Robert ; Stéphan VagnerSeries Type : Expression profiling by high […]
- GSE272928 Distinct NK Cell Function and Gene Expression in Children with Acute Lymphoblastic Leukemia in Remission Before and After Acute Exercise July 17, 2025Contributors : Abel Plaza-Florido ; Martin Perlsteyn ; Leonard Sender ; Fadia Haddad ; Dan Cooper ; Ronen Bar-Yoseph ; Alejandro Lucia ; Shlomit Radom-AizikSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChildren and adolescents who have acute lymphoblastic leukemia (ALL), often display an impaired natural killer cell ( […]
- GSE281217 Effect of diurnal oxygen variation on gene expression in Pacific white shrimp reared in green water system tanks July 17, 2025Contributors : Jason W Abernathy ; Cristhian San Andres ; Julio C García ; Nithin Sankappa ; Adela Araujo ; Trenton Corby ; Khanh Nguyen ; Melanie Rhodes ; Luke A Roy ; Donald A DavisSeries Type : Expression profiling by high throughput sequencingOrganism : Penaeus vannameiWorld aquaculture production of the Pacific white shrimp (Litopenaeus vannamei) is est […]
- GSE277607 NanoString BC360 gene signatures in luminal breast cancer July 17, 2025Contributors : Guokun Zhang ; Clarissa Gerhäuser ; Hans H Kreipe ; Nadia HarbeckSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe analyzed a cohort of 220 early breast cancer patients with ER-positive and/or progesterone receptor (PR)-positive, HER2-negative tumors.
- GSE249858 Unveiling the Molecular Legacy of Transient Insulin Resistance: Implications for Hepatic Metabolic Adaptability [RNA-Seq] July 17, 2025Contributors : Alexandre Berthier ; Loïc Guille ; Philippe LefebvreSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetabolic flexibility (MetF) refers to an organism's capacity to adapt to changes in metabolic supplies and energy demands. MetF involves various organs, such as skeletal muscle, white adipose tissues, […]
- GSE283760 OTTR-seq of FXTAS brain reveals tRNA ligase dysfunction July 17, 2025Contributors : Jason Yang ; Raghu R ChivukulaSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensProtein aggregates are a hallmark of neurodegenerative disease proposed to promote neurotoxicity through a diverse and growing set of mechanisms. Aggregation of polyglycine is specifically implicated in the pathogenesis of a […]
- GSE302678 Polycomb repression works without Siesta [ChIP] July 17, 2025Contributors : Tatyana G Kahn ; Andres Garrido ; Anastasiya Yushkova ; Maria Kim ; Alexander Glotov ; Sweda Sreekumar ; Jan Larsson ; Yuri B SchwartzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterPolycomb group proteins are essential for epigenetic repression of developmental genes. They act as […]
- GSE302472 Semaglutide in the treatment of MOSH alter the methylation pattern of genes related to glycolipid metabolism July 17, 2025Series Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensSecondary hypogonadism related to male obesity (MOSH) is a common disease among male patients with severe obesity. Semaglutide has a remarkable effect in weight loss treatment. To explore the epigenetic change mechanism of Semaglutide in the treatment of MOSH, this stu […]
- GSE302788 Effect of Arginine Supplementation on Liver and Pectoral Muscle: Tissue-Specific Lipid Metabolism in Broilers July 17, 2025Contributors : Awais Ali ; Xuan Liu ; Mebratu Melaku ; Waqar Iqbal ; Bao Yi ; Ruqing Zhong ; Liang Chen ; Teng Ma ; Hongfu ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusAbdominal fat (AF) and intramuscular fat (IMF) are key carcass traits in broilers but managing both is challenging due to their contrasting effe […]
- GSE302747 KLF2 may suppress chicken adipogenesis by enhancing the GATA2 transcription July 17, 2025Contributors : Tingting Zhang ; Qin Gao ; Yuechan Chen ; Zhiwei ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusKruppel-like factor 2 (KLF2) acts as an essential modulator of adipogenesis; nevertheless, the exact molecular pathways governing its role remain uncharacterized. This investigation characterized the exp […]
- GSE302873 Polycomb repression works without Siesta [TRIP] July 17, 2025Contributors : Tatyana G Kahn ; Andres Garrido ; Anastasiya Yushkova ; Maria Kim ; Alexander Glotov ; Sweda Sreekumar ; Jan Larsson ; Yuri B SchwartzSeries Type : OtherOrganism : Drosophila melanogasterPolycomb group proteins are essential for epigenetic repression of developmental genes. They act as multi-subunit complexes whose biochemical functions are ye […]
- GSE302881 Local metabolism and signaling of classic and 11-oxyandrogens reveal a prognostic axis in high-grade serous ovarian cancer July 17, 2025Contributors : Marija Gjorgoska ; Klemen Pečnik ; Nika Marolt ; Janez Plavec ; Tea L. RižnerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: High-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological malignancy, exhibiting marked heterogeneity that complicates treatment. The implications of in […]
- GSE302882 Exosomal miR-2137 from cadmium-treated hepatocytes drives renal ferroptosis via GPX4 suppression and is alleviated by selenium July 17, 2025Contributors : Qian Wen ; Lixing ZhanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCadmium (Cd) is a toxic heavy metal that has a significant impact on the liver and kidneys, rendering them highly susceptible to its toxic effects. However, the precise mechanism remains uncertain. Mice were exposed to Cd resulting seve […]
- GSE255926 Gene expression dynamics before and after zygotic genome activation in Drosophila early embryogenesis July 17, 2025Contributors : Yongwoo Na ; Yeon Choi ; Thi T Nguyen ; Hoang-Anh Pham-Bui ; Jeesoo Kim ; V N Kim ; Mihye Lee ; Jong-Seo KimSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterPost-transcriptional gene regulatory mechanisms are fundamental for the determination of gene expression dynamics and especially crucial fo […]