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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE300612 PANAD/C7orf25 interacts with NXF1 to promote CDK6 mRNA nuclear export and G1/S transition June 27, 2025Contributors : Jin-Yu Liu ; Huan-Hui Feng ; Shi-Mei ZhuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNuclear export factor 1 (NXF1) exerts mRNA transporter activity via binding to adaptors. We aimed to identify new NXF1 adaptors, and found that the R122/E125/G133/D139 amino acid residues of C7orf25 interacted with […]
- GSE270866 KIL transcription factors facilitate embryo growth in maize by promoting endosperm elimination via lytic cell death June 27, 2025Contributors : Nicolas M Doll ; Yannick Fierlej ; Thomas Eekhout ; Lisa Elias ; Clément Bellot ; Geng Sun ; Carolin Grones ; Stijn Aesaert ; Griet Coussens ; Riet De Rycke ; Maria Šimášková ; Emilie Montes ; Chloé Plagnard ; Peter M Rogowsky ; Yemisrach M Abebaw ; Mohammed Bendahmane ; Bert De Rybel ; Laurens Pauwels ; Thomas Widiez ; Moritz K NowackSeries T […]
- GSE235999 Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases [RNA-seq] June 27, 2025Contributors : Walid Fakhouri ; Lisha Zhu ; Jim ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMost DNA variants associated with common complex diseases fall outside the protein-coding regions of the genome, making them hard to detect and relate to a function. Although many computational tools are available for pr […]
- GSE207220 Claudin2 Upregulation: IBD and collitis-associated colon cancer [overexpression] June 27, 2025Contributor : Singh AmarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the role of claudin-2 in IBD and collitis-associated colon cancer
- GSE252599 Transcriptomic analysis of ApoE-KO/APOL1 mouse choroid plexus June 27, 2025Contributors : Teruhiko Yoshida ; Shashi Shrivastav ; Jeffrey B KoppSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe analyzed transcriptomic profiles of mouse choroid plexus by single-nuclear RNA-seq.
- GSE236241 Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases June 27, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE289633 Transcriptome profiling and co-expression network analysis of 96 Haematococcus pluvialis samples June 27, 2025Contributors : Bin Hu ; Kai Liu ; Feichao Du ; Hailiang Xing ; Xiaoyuan Su ; Tao Hu ; Feng Chen ; Yujie Qin ; Zhaozhen Dong ; Xue Sun ; Liuquan Zhang ; Jagroop Pandhal ; Nianjun Xu ; Chaoyang HuSeries Type : Expression profiling by high throughput sequencingOrganism : Haematococcus lacustrisHaematococcus pluvialis is a microalga known for producing the red c […]
- GSE267233 Single-cell transcriptome profiling reveals blast cell heterogeneity and identifies novel therapeutic target IKZF2 in t(8;21) acute myeloid leukemia (RNA-seq) June 27, 2025Contributors : Jianxiang Wang ; Shaowei Qiu ; Yu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo clarify the role of AML1-ETO in aberrant hematopoiesis, we generated conditional AML1-ETO knock-in mice. Our research indicated AML1-ETO induction impaired bone marrow hematopoietic reconstitution and resulted in aberr […]
- GSE299835 Fundamental mechanisms causing pituitary stem cell aging in mice and humans June 27, 2025Contributor : Leonard CheungSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe pituitary gland produces hormones that are required to maintain proper endocrine function throughout adult life, but organ function declines with age. In particular, pituitary stem cells lose their ability to regenerate hormone-producing cel […]
- GSE299076 Melanoma cell lines: generated from pre vs generated post anti-PD-1 therapy June 27, 2025Contributors : Takashi Inozume ; Kazuhiro AoyamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensMEL02-1 and MEL02-2 are melanoma cell lines derived from a melanoma patient. MEL02-1 was established from a pre-treatment metastatic lesion. MEL02-2 was established from post-treatment regressing lesion.
- GSE299985 Lurasidone Induces Developmental Toxicity and Behavioral Impairments in Zebrafish Embryos June 27, 2025Contributors : Wentian Li ; Fang Wang ; Zhe Feng ; Qianqian Cheng ; Yuqing Huang ; Han Xiao ; Hongjian GongSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioLurasidone, a second-generation antipsychotic, is widely used for treating schizophrenia and bipolar disorder due to its favorable metabolic profile. However, its pote […]
- GSE300381 High-avidity Cathepsin G specific CAR-T cells for the treatment of Acute Myeloid Leukemia June 27, 2025Contributors : Tara Walhart ; Feifei Song ; Marta Biondi ; Simone Stucchi ; Guangming Li ; Patrick Peishun ; Kyogo Suzuki ; Elizabeth G Hunt ; Andrew Kennedy ; Jessica E Thaxton ; Tracy Withers ; Laura E Herring ; Courtney G Elliott ; Sally A Hunsucker ; Rania Tsahouridis ; Marta Serafini ; Leah Flick ; Eben I Lichtman ; Mark Woodcock ; Lishan Su ; Zhiyuan Y […]
- GSE300384 Comparative transcriptome analysis of JAZ4 knock-out plants (jaz4-1) and Col-0 Arabidopsis thaliana plants. June 27, 2025Contributors : Maeli Melotto ; Zachariah JaramilloSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaTime point RNAseq analysis of jaz4-1 mutant vs Col-0 reveals dynamic JAZ4 mediated regulatory pathways.
- GSE270517 Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis June 27, 2025Contributors : Tousif Azmain ; Hai DoanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCardiac fibrosis is the hallmark underlying variosus forms of heart disease including aortic stenosis, contributing significantly to disease progression and mortality. However, the molecular mechanistic details remain largely unknown. […]
- GSE284454 Gut commensal Parabacteroides goldsteinii mitigates LRRK2 Parkinsonism by reducing neuroinflammation and enhancing gut homeostasis June 27, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEvidence suggests that Lewy body pathology in Parkinson's disease (PD) may originate in the gut, with intestinal inflammation serving as an early mediator via the gut-brain axis. Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common genetic risk factor for bo […]