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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE289044 Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression June 25, 2025Contributors : Lisa Schweizer ; Hilary A Kenny ; Rahul Krishnan ; Lucy Kelliher ; Agnes Bilecz ; Aasa Shimizu ; Andreas Metousis ; Rachelle Mendoza ; Thierry M Nordmann ; Sarah Rauch ; Janna Heide ; Sabrina Richter ; Yan Li ; Florian A Rosenberger ; Maximillian T Strauss ; Katherine C Kurnit ; Marvin Thielert ; Edwin Rodriguez ; Johannes B Müller-Reif ; Seik […]
- GSE253897 Gene expression data comparing HIV exposed and HIV unexposed freshly isolated umbilical cord blood derived CD34+ haematopoietic stem/progenitor cells June 25, 2025Contributors : Candice Hendricks ; Michael Pepper ; Melvin Ambele ; Juanita MelletSeries Type : Expression profiling by arrayOrganism : Homo sapiensUmbilical cord blood (UCB) is a donor source for haematopoietic stem cell transplantation but only HIV unexposed and uninfected cord blood has been used to date. HIV exposed and uninfected cord blood could potent […]
- GSE300564 Blockade of VCAM1 or VLA4 preserves cerebrovasculature and prevents cognitive decline late after stroke June 25, 2025Contributors : Kristy Zera ; Karen Bradshaw ; Li Zhu ; Oliver Hahn ; Aulden Foltz ; Todd Peterson ; Hanadie Yousef ; Davis Lee ; Elizabeth Mayne ; Nima Aghaeepour ; Tony Wyss-Coray ; Marion BuckwalterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInfarct-induced neurodegeneration increases dementia risk for at least a […]
- GSE271520 Obese individuals exhibit distinct temporal gene expression dynamics in response to influenza vaccination June 25, 2025Contributors : Megan Hockman ; Julia Matthews ; Michael Carlock ; Ted Ross ; David Gresham ; Elodie GhedinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe effectiveness of the seasonal influenza vaccine varies between individuals. Specific risk groups with comorbidities, such as the obese, have an increased risk of i […]
- GSE269714 Erianin inhibits the progression of pancreatic cancer by directly targeting AKT and ASK1 June 25, 2025Contributors : Minghan Qiu ; Ruxue Liu ; Zhen Yang ; Huaqing WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensErianin, a natural product extracted from Dendrobium, possesses multiple pharmacological properties, including antioxidative and antitumor activities. The objective of this study was: to evaluate the anti-pan […]
- GSE283287 Changes of gene expression in DRG tissue after pathologic pain June 25, 2025Contributors : ManXiu Xie ; RenChun Lai ; YiBin Xiao ; ShiYu Zuo ; XiaoLong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo identify common mechanisms and targets regulating different types of pathological pain, we established models for neuropathic pain induced by spinal nerve ligation (SNL), inflammatory pain […]
- GSE277090 VGF-derived TLQP21 peptide ameliorates tumor progression, pain and depression-like behaviors in an orthotopic mouse model of pancreatic ductal adenocarcinoma June 25, 2025Contributors : Shuying Huang ; Pei Xia ; Yixiu Zeng ; Qiuyi Chen ; Wenbao Cai ; Yuying Yang ; Yangyang Ou ; Jun Chen ; Wei-Jye Lin ; Xiaojing YeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn summary, we report that the VGF-derived TLQP21 is a promising target for pharmaceutical interventions in pancreatic ductal ade […]
- GSE300189 Life long effects of radiation and high fat dieat on the mouse right ventricular tissue June 25, 2025Contributors : Siras Hakobyan ; Roksana Zakharyan ; Ani Stepanyan ; Arsen Arakelyan ; David A GoukassianSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe studied the long-term effects of single whole-body gamma and simulated GCR irradiation (IR) and consumption of a Western Diet (WD) on the heart's right ventricle […]
- GSE297863 Immune-related cutaneous adverse events display distinct clinical and molecular characteristics, depending on immune checkpoints targeted June 25, 2025Contributors : Lukas Kraehenbuehl ; Nicola Winkelbeiner ; Adhideb Ghosh ; Reinhard Dummer ; Barbara Meier-SchiesserSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground/Objectives: Immune-related cutaneous adverse events (ircAE) are common complications of cancer immunotherapy and provide insight into immune-relate […]
- GSE300409 PAF1 N-terminal extension-generated PAF1c-SKIP-CDKB module regulates plant-specific cell cycle in the plant kingdom June 25, 2025Contributors : Yan Li ; Renshen YuanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Chlamydomonas reinhardtiiThrough systematic biochemical analyses, we identified a novel protein-protein interaction between PAF1 and SKIP in Chlamydomonas reinhardtii. To investigate the functional significance of this interaction, we […]
- GSE300290 RRM2-targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling June 25, 2025Contributors : Weiliang Hou ; Weifeng Hong ; Songhua Cai ; Dandan Guo ; Zhiping Yan ; Jinyu Zhu ; Yang Shen ; Juncheng Wan ; Xudong Qu ; Wen Zhang ; Runkang Zhao ; Zhao Xie ; Zhongji Chen ; Tong Jiang ; Yaling Lin ; Wenlong Jia ; Ling Wang ; Zhao Huang ; Xuexin Li ; Bufu TangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapi […]
- GSE300435 Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [TCR-Seq] June 25, 2025Contributors : Min-Min Chen ; Qinhang Gao ; Huiheng Ning ; Kang Chen ; Yang Gao ; Chaoqun Liu ; Linnan Zhu ; Wei Zhou ; Jieying Pan ; Lusheng Wei ; Dingwen Zhang ; Min Yu ; Qingling Zhang ; Rufu Chen ; Zemin ZhangSeries Type : OtherOrganism : Homo sapiensThis study aims to explore the role of nerves in tumor biology, particularly focusing on their function a […]
- GSE300543 The Integrator complex is required for optimal lytic lifecycle of Kaposi’s Sarcoma-Associated Herpesvirus [RNA-seq] June 25, 2025Contributors : Amy Nguen ; Tianqi Li ; Conner M Traugot ; Kimberly Paulson ; Mingyi Xie ; Zhe MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Integrator complex (INT) is an essential regulator of RNA biogenesis across evolution. Most current findings describe INT’s function in states of equilibrium, presenting a r […]
- GSE300544 The Integrator complex is required for optimal lytic lifecycle of Kaposi’s Sarcoma-Associated Herpesvirus [ChIP-seq] June 25, 2025Contributors : Amy Nguen ; Tianqi Li ; Conner M Traugot ; Kimberly Paulson ; Mingyi Xie ; Zhe MaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe Integrator complex (INT) is an essential regulator of RNA biogenesis across evolution. Most current findings describe INT’s function in states of equilibrium, […]
- GSE285387 Identifying downstream targets of ankrd1a in heart regeneration after cryoinjury in adult zebrafish June 25, 2025Contributors : Mirjana Novkovic ; Emilija Milosevic ; Jovana Jasnic ; Andjela Milicevic ; Snezana KojicSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioIn contrast to humans, zebrafish have a remarkable ability to regenerate injured heart through a complex and highly orchestrated process involving all cardiac structures. […]