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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE235617 Downregulation of miR-182-5p by NFIB promotes NAD+ salvage synthesis in colorectal cancer by targeting NAMPT [ChIP-Seq] June 22, 2025Contributors : Li Zhou ; Song He ; Zhihang Zhou ; Shu ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNuclear factor IB (NFIB) plays an important role in tumors. Our previous study found that NFIB can promote colorectal cancer (CRC) cell proliferation in acidic environments. However, its biological fun […]
- GSE236757 Downregulation of miR-182-5p by NFIB promotes NAD+ salvage synthesis in colorectal cancer by targeting NAMPT June 22, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE236756 Downregulation of miR-182-5p by NFIB promotes NAD+ salvage synthesis in colorectal cancer by targeting NAMPT [miRNA-seq] June 22, 2025Contributors : Li Zhou ; Song He ; Zhihang Zhou ; Shu ChenSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensNuclear factor IB (NFIB) plays an important role in tumors. Our previous study found that NFIB can promote colorectal cancer (CRC) cell proliferation in acidic environments. However, its biological functions and […]
- GSE263222 Expanding the diversity of bacterial DNA partitioning: A CTP-independent ParABS system for plasmid partitioning in Streptomyces June 22, 2025Contributors : Kirill V Sukhoverkov ; Tung B LeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Streptomyces coelicolor A3(2)The ATP- and CTP-dependent ParA-ParB-parS segrosome is a macromolecular complex that segregates chromosomes/plasmids in most bacterial species. CTP binding and hydrolysis enable ParB to slide alo […]
- GSE244946 NOTCH1 reverses immune suppression in small cell lung cancer through reactivation of STING [scRNA-seq] June 22, 2025Contributors : Nitin Roper ; Yoo S Kim ; Xinyu WenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDownregulation of antigen presentation and lack of immune infiltration are defining features of small cell lung cancer (SCLC) limiting response to immune checkpoint blockade (ICB), While a high MHC Class I, immune-inflamed […]
- GSE270755 Single-cell sequencing of plasma cell mastitis June 22, 2025Contributors : Chi Pan ; Qingtao NiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell sequencing of plasma cell mastitis
- GSE270612 Overexpression of SLC2A1, ALDOC and PFKFB4 in the glycolysis pathway drives strong drug resistance in 3D HeLa tumor cell spheroids. June 22, 2025Contributors : Tong Wang ; Xueting Wang ; Xuli Zheng ; Zhongfang Guo ; Ali Mohsin ; Yingping Zhuang ; Guan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe three-dimensional (3D) tumor spheroid model exhibits enhanced fidelity in replicating the tumor microenvironment and demonstrates exceptional resistance to cl […]
- GSE296923 The RNA-Binding Protein DDX39B Promotes Colorectal Adenocarcinoma Progression by Stabilizing DCLK1 June 22, 2025Contributors : Shichao Liu ; Shoucai Zhang ; Hongxi Zhao ; Yingjie Liu ; Zeyu Zhang ; Xueyan Geng ; Maopeng Yin ; Yongyuan Liang ; Guixi ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs an RNA-binding protein (RBP), DDX39B increased the stability of DCLK1-B mRNA, a variant highly expressed in colorectal cancer kn […]
- GSE297822 Coupling chromosome organization to genome segregation in Archaea June 22, 2025Contributors : Parul Pal ; BK Tung Le ; Daniela BarillàSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Sulfolobus acidocaldarius DSM 639Chromosome segregation is a fundamental process in all life forms and requires coordination with genome organization, replication and cell division. The mechanism that mediates chromo […]
- GSE300049 LARP-1 maintains the structure and function of mitochondria by regulating mitochondrial crista-related proteins June 22, 2025Contributors : Yan Bai ; Tengfei Ma ; Jingyang Li ; Shunkai Chen ; Chonglin YangSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansMitochondria are the metabolic center and powerhouses of cells by coordinating the tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS) and electron transport to generat […]
- GSE300052 The keratin-associated protein epiplakin is down-regulated in psoriasis June 22, 2025Contributors : Hannes Kühtreiber ; Michael Mildner ; Peter FuchsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEpiplakin (EPPK1) is a protein that specifically interacts with keratin filaments in the epidermis. It helps to stabilize this filament network when the cells are under stress. In the present study we investig […]
- GSE300223 N6-methyladenosine and the NEXT complex direct Xist RNA turnover and X inactivation dynamics [ChrRNA-seq_XistDelm6A] June 22, 2025Contributors : Guifeng Wei ; Neil BrockdorffSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusX chromosome inactivation (XCI) in mammals is orchestrated by the non-coding RNA Xist which together with specific interacting proteins, functions in cis to silence an entire X chromosome. Defined sites on Xist RNA carry the N6-m […]