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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE206105 Neocortical temporal patterning by a two-layered regulatory structure June 14, 2025Contributors : Guohua Yuan ; Zhe Zhao ; Yinqing LiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIn the developing neocortex, diverse neurons of defined types and numbers are orderly produced by a limited population of radial glial progenitors (RGPs) as […]
- GSE233348 Transcriptome sequencing of Ilex x 'Nellie R. Stevens' and its yellow leaf mutant June 14, 2025Contributors : Yiping Zou ; Yajian Huang ; Donglin Zhang ; Mingzhuo Hao ; Yunlong Yin ; Youwang LiangSeries Type : Expression profiling by high throughput sequencingOrganism : IlexIlex x ‘Whoa Nellie’ is a yellow leaf (YT) mutant of I. x ‘Nellie R. Stevens’ (WT), an important ornamental woody species. However, the molecular mechanism of the YT mutant remains […]
- GSE206127 Machine Learning-based Exceptional Response Prediction of Nivolumab Monotherapy with Circulating MicroRNAs in Non-Small Cell Lung Cancer June 14, 2025Contributors : Yifan Zhang ; Yasushi Goto ; Shigehiro Yagishita ; Yuki Shinno ; Kazue Mizuno ; Naoaki Watanabe ; Yusuke Yamamoto ; Nobuyuki Ota ; Takahiro Ochiya ; Yu FujitaSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensDetecting cancer patients with exceptional response to immune check-point inhibition therapy is […]
- GSE248959 PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation June 14, 2025Contributors : Magdalena Madej ; Phuong Cao Thi Ngoc ; Sowndarya Muthukumar ; Anna Konturek-Cieśla ; Silvia Tucciarone ; Alexandre Germanos ; Christian Ashworth ; Knut Kotarsky ; Sudip Ghosh ; Zhimeng Fan ; Helena Fritz ; Izei Pascual-Gonzalez ; Alain Huerta ; Nicola Guzzi ; Anita Colazzo ; Giulia Beneventi ; Hang-Mao Lee ; Maciej Cieśla ; Christopher Douse […]
- GSE234948 NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression June 14, 2025Contributors : Ken Takashima ; Sabine Dietmann ; Eric GreerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPost-translational modifications of histone tails alter chromatin accessibility to regulate gene expression. Some viruses exploit the importance of histone modifications by expressing histone mimetic proteins that […]
- GSE299337 Nano-flower-stick S-scheme Au/MoS2/Bi2S3 heterojunction with multiple enzyme-like activity for efficient tumor photothermal and photodynamic combination therapy June 14, 2025Contributors : Boyin Jia ; Wei Liu ; Xinrui Yan ; Xintong HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNano-catalytic therapy mediated by reactive oxygen species (ROS) is a highly promising tumor treatment strategy. However, the unique physiological and biochemical characteristics of tumor microenvironment, such a […]
- GSE249315 The human microglia response a resource to better understand microglia states in health and disease June 14, 2025Contributors : Gijsje J Snijders ; Katia de Paiva Lopes ; Marjolein M Sneeboer ; Benjamin Z MullerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMicroglia, the immune cells of the brain, are increasingly implicated in neurodegenerative disorders through genetic studies. However, how genetic risk factors for these disea […]
- GSE270031 Heterogeneous macrophage activation in injured skeletal muscle June 14, 2025Contributors : Xingyu Wang ; Justin Moy ; Yinhang Wang ; Gregory R Smith ; Frederique Ruf-Zamojski ; Pawel Przytycki ; Stuart C Sealfon ; Lan ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMacrophages are the predominant inflammatory cells during skeletal muscle injury repair. They are required for the complete rep […]
- GSE269938 Loss of Activating transcription factor 3 restricts KRASG12D’s ability to promote PanIN progression through epithelial specific transcriptional regulation June 14, 2025Contributors : Martin Martin ; Fatemeh Mousavi ; Liena Zhao ; Christopher PinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer-related deaths in North America with ~12% survival 5 years after diagnosis. Risk factors for PDAC, including smoking and […]
- GSE280576 RNF5-DNAJA1 Axis Dictates Selinexor Sensitivity of Multiple Myeloma by Regulating Mitochondrial Function June 14, 2025Contributors : Mengqi Wang ; Linchuang Jia ; Danchen SuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed RNA-seq to analyse the different expression genes of RNF5-KD LP-1 cells and non-target control.
- GSE278156 The high-throughput shRNA cleavage assays on 46,000 variants June 14, 2025Contributors : Tuan Anh Nguyen ; Trung Duc Nguyen ; Thi Nhu Y LeSeries Type : OtherOrganism : synthetic constructDICER-LIKE1 (DCL1), a plant-specific RNase III enzyme, is fundamental to post-transcriptional gene regulation mediated by microRNAs (miRNAs). DCL1 processes precursor miRNAs into mature miRNAs, typically 20–22 nucleotides in length. Despite its cr […]
- GSE297902 TBK1 enhances antifungal immunity by forming a SRC-TBK1 positive feedback loop in phagosomes of macrophages June 14, 2025Contributors : Yiting Feng ; Xiaochen Cheng ; Tian Chen ; Chengjiang GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTBK1 is a serine/threonine kinase known for its role in antiviral immunity. Here, we identify TBK1 as a key amplifier of antifungal immune responses. Using a mouse model of Candida albicans infection, […]
- GSE299205 RNA sequencing analysis of the genes regulated by CueR in Vibrio parahaemolyticus. June 14, 2025Contributors : Chengkun Zheng ; Yimeng ZhaiSeries Type : Expression profiling by high throughput sequencingOrganism : Vibrio parahaemolyticusThe transcriptome of the wild type strain and ΔcueR of Vibrio parahaemolyticus was compared by RNA sequencing analysis.
- GSE299292 Expression profiling data derived from mouse atrial tissues treated with myocardial infarction (MI) for 0, 1, 3, and 7 days. June 14, 2025Contributor : Yun-Long ZhangSeries Type : Expression profiling by arrayOrganism : Mus musculusAtrial fibrillation (AF) following myocardial infarction (MI) represents a significant clinical challenge due to the lack of effective therapeutic options. However, the precise mechanisms underlying AF development remain poorly understood. This study systematically […]
- GSE206090 Gonadal gap junctions activate Notch signaling to suppress intestinal innate immunity via p38/PMK-1 and lysosome pathway June 14, 2025Contributors : Haijun Tu ; Xiumei Zhang ; Yirong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansWe showed that the innexin genes encoding gap junction subunits positively regulated GLP-1/Notch signaling to suppress the innate immunity of C. elegans via PMK-1/p38 pathway. The unc-17 acts in the dowmstream […]