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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE277855 Systems-level analysis provides insights on methanol-based production of l-glutamate and its decarboxylation product γ-aminobutyric acid by Bacillus methanolicus June 12, 2025Contributors : Marta Irla ; Nærdal Ingemar ; Virant David ; Brautaset Trygve ; Busche Tobias ; Goranovič Dušan ; Haupka Carsten ; Heux Stephanie ; Kosec Gregor ; Rückert Christian ; Wendisch Volker F ; Brito Luciana F ; Vicente Cláudia MSeries Type : Expression profiling by high throughput sequencingOrganism : Bacillus methanolicusBacillus methanolicus is th […]
- GSE281267 BAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A-HDAC1 June 12, 2025Contributors : Alan Monziani ; Igor UlitskySeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusChromatin modifications play a key role in the regulation of gene expression during development and adult physiology. Histone acetylation, and in particular H3K27a […]
- GSE278533 Gene expression profile at single cell level of articular cartilage superficial cells from sham and dmm surgery mice and long bone periosteum cells from steady state mice. June 12, 2025Contributors : Rui Yue ; Qiaoling Zhu ; Dandan Cao ; Wanyu ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCharacteristics of the chondroprogenitors cells remain unidentified. Here we identify a chondroprogenitor population, which specifically expresses Procr,and used single cell RNA sequencing (scRNA-seq) and bulk R […]
- GSE249902 CELSR3 deficiency leads to tic-related behaviors and dopaminergic alterations in the striatum June 12, 2025Contributors : Philip Moos ; Marco BortolatoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe gene CELSR3 (cadherin EGF LAG seven‐pass-G‐type receptor 3) has been recently recognized as a high-confidence risk factor for tic disorders (TD). Celsr3 mutant mice displayed tic-like grooming stereotypies and jerks, as well […]
- GSE299635 Metastatic site influences driver gene function in pancreatic cancer [[InVitro ATAC-Seq]] June 12, 2025Contributors : Kaloyan M Tsanov ; Yu-Jui Ho ; Scott W LoweSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDriver gene mutations can increase the metastatic potential of the primary tumor, but their role in sustaining tumor growth at metastatic sites is poorly understood. A paradigm of such mutations is ina […]
- GSE272406 Pan-viral ORFs discovery using massively parallel ribosome profiling June 12, 2025Contributors : Shira Weingarten-Gabbay ; Pardis C SabetiSeries Type : OtherOrganism : Homo sapiens ; synthetic constructDefining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively parallel ribosome profiling (MPRP) to determ […]
- GSE269356 Gene Signature-guided Drug Screening Identified Narciclasine as a Potential Therapeutic Drug for Renal Interstitial Fibrosis June 12, 2025Contributors : An Xiao ; Xiaomei ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculus ; Rattus norvegicusChronic Kidney Disease (CKD) is characterized by progressive tubulointerstitial fibrosis (TIF), a condition not adequately addressed by existing therapies. To identify potential compounds that could slow or halt the […]
- GSE299161 MALNC: A new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response June 12, 2025Contributors : Anne Neddermeyer ; Xiangfu Zhong ; Elisabetta Cozzi ; Sören LehmannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs the non-coding genome remains poorly defined in acute myeloid leukemia (AML), we aimed to discover and characterize novel long non-coding RNAs (lncRNAs) relevant for AML biology and treatm […]
- GSE299104 Nephron segmentation and patterning in kidney organoids can be modulated by distinct FGF subfamily members June 12, 2025Contributors : Allara K Zylberberg ; Emma I Scully ; Pei Xuan Er ; Hannah Baric ; Michelle Scurr ; Mian Xie ; Thanushi Peiris ; Sara E Howden ; Kynan T Lawlor ; Melissa H LittleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman pluripotent stem cell-derived kidney organoids replicate embryonic nephrogenesis in a 3D-c […]
- GSE299503 LncRNA RP11-284N8.3 regulates the expression and alternative splicing of genes associated with sepsis-induced acute lung injury June 12, 2025Contributors : Yanwei Cheng ; Xue Cao ; Ning DingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSepsis-induced acute lung injury (ALI) poses a significant threat to human health, necessitating further investigation into its underlying mechanisms. Long noncoding RNAs (lncRNAs) have emerged as key regulators in various d […]
- GSE299293 Social isolation primes anxiety via a hippocampal iron-α-synuclein cascade June 12, 2025Contributors : Zhuo Wang ; Sifan Yang ; Yuhan Zhang ; Jinhui ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study reveals a novel mechanism linking social isolation to anxiety through a glucocorticoid (GC)-driven, ventral hippocampal (vHip)-specific iron-α-synuclein (α-Syn) axis. Social isolation activates glu […]
- GSE299530 EPITHELIAL REMODELING AND MICROBIAL DYSBIOSIS IN THE LOWER RESPIRATORY TRACT OF VITAMIN A-DEFICIENT MOUSE LUNGS June 12, 2025Contributors : Kiloni Quiles ; Feng-Zhi Shao ; W. Evan Johnson ; Felicia ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculus ; lung metagenomeThe World Health Organization identified vitamin A deficiency (VAD) as a major public health issue in low-income communities and developing countries, while additional studies ha […]
- GSE299541 MALNC: A new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response [ChIRP-seq] June 12, 2025Contributors : Anne Neddermeyer ; Xiangfu Zhong ; Elisabetta Cozzi ; Sören LehmannSeries Type : OtherOrganism : Homo sapiensAs the non-coding genome remains poorly defined in acute myeloid leukemia (AML), we aimed to discover and characterize novel long non-coding RNAs (lncRNAs) relevant for AML biology and treatment. We first identified over-expressed lncRN […]
- GSE299633 Metastatic site influences driver gene function in pancreatic cancer [InVitro RNA-Seq] June 12, 2025Contributors : Kaloyan M Tsanov ; Yu-Jui Ho ; Scott W LoweSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDriver gene mutations can increase the metastatic potential of the primary tumor, but their role in sustaining tumor growth at metastatic sites is poorly understood. A paradigm of such mutations is inactivation of S […]
- GSE276077 The PARP1-EXD2 Axis Orchestrates R-Loop Resolution to Safeguard Genome Stability June 12, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensR-loops represent three-stranded nucleic acid structures comprising an RNA-DNA hybrid and a displaced single-stranded DNA. Deregulation of R-loop dynamics can obstruct DNA transcription and replication processes, compromising genome integrity and contributing […]