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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE273604 Effect of depletion of FAM129B on gene expression during skeletal muscle differentiation of C2C12 cells June 1, 2025Contributors : Wang Yan ; Yushen Lu ; Jinhui HouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMuscle atrophy, a decline in muscle mass and quantity caused by a variety of factors such as cancer, aging, and long-term use of glucocorticoids, manifested at the molecular level as excessive protein catabolism. Muscle atrop […]
- GSE270525 CD8(+) T cells cell-in-cell mediates colorectal cancer progression via P38 activation June 1, 2025Contributors : Yisheng Wei ; Xikai Luo ; Fang Su ; Yufei ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCell-in-cell(CIC) refers to the active internalization of one or more living cells into another. However, the biological significance and clinical implications of CIC between immune cells and cancer remain unclea […]
- GSE93046 Expression data from BJ-hTERT cells expressing shRNA control vector or shRNA against p53. June 1, 2025Contributors : Batsheva Kerem ; Maayan RonigerSeries Type : Expression profiling by arrayOrganism : Homo sapiensp53 is a major tumor suppressor gene that is frequently inactivated in human cancers. One prominent suppressive function of p53 is executing cell cycle arrest, senescence and apoptosis upon stress. Importantly, p53 loss is a prerequisite for cancer […]
- GSE274624 Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation [ATAC-seq] June 1, 2025Contributors : Audrey J Marsh ; Sergei Pirogov ; Abby J Ruffridge ; Suresh Sajwan ; Tyler J Gibson ; George Hunt ; Melissa M Harrison ; Mattias MannervikSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterImmediately after fertilization the genome is transcriptionally quiescent. Maternally encoded p […]
- GSE255379 Interleukin-6 Trans Signaling and STAT-3 Activation Promote Neutrophilic Inflammation in Alcohol-Associated Hepatitis June 1, 2025Contributors : Gaurav Sarode ; Vikrant RachakondaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlcohol associated hepatitis (AH) is characterized by neutrophilic inflammation leading to liver injury. Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates hepatic regeneration and hepatic acute phase responses. I […]
- GSE236604 Chromatin Reprogramming of In Vitro Fertilized and Somatic Cell Nuclear Transfer Bovine Embryos During Embryonic Genome Activation [ATAC-Seq] June 1, 2025Contributor : Grow EdwardSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Bos taurusReprogramming of the gamete into a developmentally competent embryo identity is a fundamental aspect of preimplantation development. One of the most important processes of this reprogramming is the transcriptional awakening during embry […]
- GSE297814 Reproducible single cell annotation of programs underlying T cell subsets, activation states, and functions June 1, 2025Contributors : Dylan Kotliar ; Michelle Curtis ; Soumya RaychaudhuriSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCITE-sequencing and TCR-sequencing of sorted activated, unactivated, and mock T cells derived from blood. T cells from five healthy human donors were stimulated with a peptide pool (CEFX, JPT) and […]
- GSE268505 Physical exercise improves the neuronal function in ischemic stroke via microglial CB2R/P2Y12 signaling June 1, 2025Contributors : Xiao-fei He ; Xiao-feng Yan ; Ge Li ; Yun Zhao ; Jing Luo ; Jing-hui Xu ; Hai-qing Zheng ; Li-ying ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPhysical exercise (PE) may be the single most important and accessible lifestyle habit throughout life, it inhibits the neuroinflammatory response and pro […]
- GSE297985 TMEM259 alleles modulate respiratory syncytial virus infection and ER-stress-triggered apoptosis June 1, 2025Contributors : Sibylle Haid ; Martin Wetzke ; Isra Nurhassen ; Vanessa Milke ; Daniel Todt ; Melle Holwerda ; Ronald Dijkman ; Thomas Zillinger ; Danny Jonigk ; Matthias Lange ; Christina Grethe ; Jessica Wenzl ; Bianca Klee ; Cornelia Gottschick ; Rafael Mikolajczyk ; Lars Kaderali ; Robert Geffers ; Yeremia G Adhisantoso ; Jan Voges ; Jörn Ostermann ; Gesi […]
- GSE297918 Transcriptome analysis to study expression under desiccation stress of Salmonella enterica subsp. enterica serovar Agona str. 460004 2-1 on low moisture food (cereal) June 1, 2025Contributors : Sultana Solaiman ; Ellie Meeks ; Ian Hines ; Jie Zheng ; Maria HoffmannSeries Type : Expression profiling by high throughput sequencingOrganism : Salmonella enterica subsp. enterica serovar AgonaSalmonella enterica serovar Agona (S. Agona) is a foodborne pathogen that caused recurrent multistate outbreaks associated with cereal between 1998 an […]
- GSE298059 Single-Cell RNA-Seq Analysis of Rat Cavernous Tissue Reveals Cellular Heterogeneity and Molecular Alterations in Cavernous Nerve Injury-Induced Erectile Dysfunction June 1, 2025Contributor : Biao LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusErectile dysfunction (ED) secondary to cavernous nerve injury (CNI) is a common complication of pelvic surgeries, yet its cellular pathophysiology remains incompletely characterized. Here, we generated a high-resolution single-cell transcriptomic […]
- GSE298195 Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging [Quantseq_cell] June 1, 2025Contributors : Gabriele Civiletto ; Dario Brunetti ; Giulia Lizzo ; Alix Zollinger ; Sylviane Metairon ; Jerome N Feige ; Philipp GutSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSmall molecular food components contribute to health benefits of diets rich in fruits, vegetables, herbs, and spices. The cellular mechanism […]
- GSE298196 Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging [Quantseq_muscle] June 1, 2025Contributors : Gabriele Civiletto ; Dario Brunetti ; Giulia Lizzo ; Alix Zollinger ; Sylviane Metairon ; Jerome N Feige ; Philipp GutSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSmall molecular food components contribute to health benefits of diets rich in fruits, vegetables, herbs, and spices. The cellular mechanism […]
- GSE269422 Single-Cell Sequencing Analysis of KLF5-Induced Multilineage Reprogramming in EpiSCs June 1, 2025Contributors : Xinyu Wu ; Yinhua HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring early embryogenesis, Kruuppel-like factor KLF5 is expressed in inner cell mass (ICM), trophectoderm (TE), and primordial germ cell (PGC). It is wellknow to be essential for specifying the TE fate, as well as redundantly with KLF […]
- GSE297774 Alterations of Epigenetic Modifications and 3D Genomic Architecture Drive Gene Expression Shifts in Primary Trastuzumab Resistance of HER2 Positive Breast Cancer [RNA-seq] June 1, 2025Contributors : Duan Ningjun ; Hua Yijia ; Zhou Zhengxing ; Li Wei ; Yin YongmeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrimary trastuzumab resistance poses a significant challenge in the treatment of HER2-positive breast cancer. Despite various proposed mechanisms and responses to address this resistance, curren […]