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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE268705 Silencing of long noncoding RNA P53RRA suppressed ferroptosis in prostate cancer by activating the AKT signaling pathway May 30, 2025Contributors : Junhao Liao ; Gaohuang Chen ; Lilin Zhou ; Jinpeng Gu ; Sihua Zhu ; Chunling Li ; Tengyu Yang ; Chonghe JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Investigations regarding the function of ferroptosis in prostate cancer (PCa) progression are still rare. Therefore, this study revealed […]
- GSE267692 Comprehensive serum metabolic snapshots enable diagnosis, prognosis, and monitoring for brainstem gliomas [I] May 30, 2025Contributors : Keke Li ; Ruimin Wang ; Zhengying GuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBrainstem gliomas (BSG) is a highly malignant central nervous system childhood tumors with a poor prognosis of a 5-year survival rate of < 10%. Metabolism during radiotherapy is a dynamic and precisely programmed proces […]
- GSE144626 JC virus propagation is potentiated by glial replication and accelerated by demyelination-associated glial proliferation [scRNA-seq] May 30, 2025Contributors : Cui Li ; Nguyen P Huynh ; Steven J Schanz ; Martha S Windrem ; Steven A GoldmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProgressive multifocal leukoencephalopathy (PML) is a demyelinating infection of the brain of immunosuppressed individuals, mediated by the gliotropic polyomavirus JCV. JCV replic […]
- GSE269479 Effect of non-structural protein 1 (NS1) of H5N1 on CK2 expression, p53 signaling pathway and cell proliferation May 30, 2025Contributors : Junfeng Zhu ; Man Zhang ; Yingyue ZengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNS1 (Non-structuralprotein1) is a non-structural protein of avian influenza viruses that can interact with a variety of host proteins. Our previous studies have demonstrated the interaction between NS1 and NOLC1 (nucleol […]
- GSE146584 Examining changes in the chromosomal interaction network in replicative senescent, rapamycin treatment, and p65 inhibition May 30, 2025Contributor : Tom SuterSeries Type : OtherOrganism : Homo sapiensAnalysis of HiC genome wide chromosomal interaction data in the context of replicative senescence, rapamycin treatment, the withdrawal of rapamycin, and with p65 inhibition in rapamycin withdrawal. This was done in order to determine what changes in chromosomal architecture occur during replica […]
- GSE146572 Genome wide mapping of open chromatin in senescence cells upon knockdown of senescence associated transcription factors May 30, 2025Contributor : Tom SuterSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensATAC-seq was performed upon senescent BJ fibroblasts upon controls shRNA or knockdown of p65, SMAD2 or SMAD3, or NFI family members, in order to determine the role of each factor upon senescence associated enhancers.
- GSE297514 Therapeutic Potential of Human Amniotic Membrane-derived Mesenchymal Stem Cell Conditioned Medium in Combating Oxidative Stress and Age-Related Female Infertility May 30, 2025Contributor : Kihae RaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOxidative stress is a crucial factor accelerating age-related functional deterioration of reproductive organ and fertility. Recently, human amniotic membrane-derived mesenchymal stem cells (AMSCs) have emerged as a promising source with notable potent […]
- GSE247300 PSPC1 selectively controls tumorigenesis and oncogenic transcription in acute myeloid leukemia [ChIP-seq] May 30, 2025Contributors : Mingjiang Xu ; Juyeong Hong ; Pinpin SuiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) is an aggressive hematopoietic malignancy characterized by the blockage of myeloid cell differentiation and uncontrolled proliferation of immature myeloid cells. Here, we show […]
- GSE298117 RNA Sequencing Analysis of Osteoclast Precursor Cells under Dexamethasone Stimulation May 30, 2025Contributor : Tao YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGlucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a refractory joint disease caused by prolonged and excessive use of glucocorticoids (GCs). Excessive osteoclast activation has been implicated in the pathological bone erosion of GIO […]
- GSE297609 NK cells in the female reproductive tract (FRT) acquire an effector transcriptional program during menstruation May 30, 2025Contributors : Christopher D Scharer ; Mark E Williams ; Alison Swaims-KohlmeierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo evaluate the impact of the menstrual cycle on the transcriptional programs of NK cells in the female reproductive tract (FRT), we compared NK cells (Live lymphocytes, CD45.2+, DX5+, NK1.1+, […]
- GSE298138 RNA-seq analysis of MLO-Y4 cells under hypoxic conditions May 30, 2025Contributors : Kohei Narita ; Fumitoshi Ohori ; Aseel Marahleh ; Jinghan Ma ; Jiayi Ren ; Angyi Lin ; Ziqiu Fan ; Kou Murakami ; Hideki KitauraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the effects of hypoxia on osteocytes, we cultured MLO-Y4 osteocytic cells under normoxic (20% O₂) and hypoxic (2% O […]
- GSE298159 Contrasting functions of CD73 and adenosine in CD8+ T cell exhaustion May 30, 2025Contributors : Juan Saavedra-Almarza ; Solange Gouët ; Felipe Malgue ; Catalina Bascuñan ; Camilo Villaman ; Moira García-Gómez ; Andrés Hernández-Oliveras ; Javiera Reyes-Alvarez ; José Corrales-Bermúdez ; Joaquín De la Rosa ; Alberto Martin ; Álvaro Lladser ; Mario Rosemblatt ; María Rosa Bono ; Daniela SaumaSeries Type : Expression profiling by high throu […]
- GSE298192 COMMD4, a novel driver for skin cutaneous melanoma progression via targeting p85 to activate PI3K/Akt signaling May 30, 2025Contributor : Xiaoqiang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSkin cutaneous melanoma (SKCM), the most aggressive form of cutaneous malignancy globally, remains poorly understood in terms of its molecular drivers. Although the copper metabolism MURR1 domain (COMMD) protein family has been associated with on […]
- GSE266643 Babaco Mosaic Virus (BabMV) induces genome-wide transcriptomic reprogramming in Carica papaya. May 30, 2025Contributors : Maria G Mariduena ; Hamada AbdElgawad ; Mohammad K Okla ; Juan M Cevallos ; Gerrit M Beemster ; Carlos NocedaSeries Type : Expression profiling by high throughput sequencingOrganism : Carica papayaThe Babaco Mosaic Virus (BabMV) is a Potexvirus that affects babaco (Vasconcellea heilbornii) and papaya (Carica papaya) plants. To understand the i […]
- GSE297016 Distinct Characteristics of Brain Metastasis in Lung Adenocarcinoma: Development of High-Confidence Cell Lines May 30, 2025Contributors : Jintao He ; Zen-ichi Tanei ; Shinya TanakaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLung cancer is a leading cause of cancer-related deaths worldwide, with brain metastasis occurring in approximately 30-55% of patients, particularly in lung adenocarcinoma. Due to the challenges in obtaining genuine […]