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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE280611 Loss of ALK3 ameliorates acute, but aggravates chronic lung inflammation in vivo May 29, 2025Contributors : Mathias Hochgerner ; Yamei Jiang ; Shenfei Sun ; Fujing Huang ; Leigh Marsh ; Xinhua Lin ; Xiaofang TangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusALK3 (BMPR1a) is a type-1-receptor of the TGF-β-receptor superfamily, which translates mostly bone morphogenetic proteins, but also TGF-β1. Previously, we […]
- GSE278972 Irx3 controls a sumoylation-dependent epigenetic switch between adipogenesis and osteogenesis May 29, 2025Contributors : Pierre Chymkowitch ; Bjune Jan-Inge ; Dankel Simon ; Mellgren GunnarSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusBackground IRX3 is implicated in genetic predisposition to obesity via the FTO variant locus. IRX3 shows FTO risk allele-dependent upregulation specifically during early adipog […]
- GSE205328 Small RNA of sugar beet in response to drought stress May 29, 2025Contributor : Chunlei ZouSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Beta vulgarisWe analyzed Small RNAs from sugar beet leaves under water control treatment using high-throughput sequencing technology and bioinformatic approaches to explore the genome-wide quantity of Small RNAs and their potential function in the regulati […]
- GSE298184 A Mechanistic basis of fast myofiber vulnerability in neuromuscular diseases [Multiome] May 29, 2025Contributors : Matthieu Dos Santos ; Svetlana Bezprozvannaya ; John R. McAnally ; Chunyu Cai ; Ning Liu ; Eric N. OlsonSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusSkeletal muscle denervation is a characteristic feature of neuromuscular diseases such […]
- GSE237645 Transcriptional analysis of TDC in a fluorescent reporter model May 29, 2025Contributors : Alessandra Fiore ; Michela Riba ; Paolo Provero ; Mirela KukaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTDC are hematopoietic cells that combine dendritic cell (DC) and conventional T cell markers and functional properties. To investigate the gene expression profile of TDC, we performed a bulk RNA se […]
- GSE234275 Hepatic Dyrk1b regulates whole body glucose homeostasis by modulating Wbp2 expression May 29, 2025Contributors : Lianju Li ; Ruixin Liu ; Jiqiu Wang ; Guang NingSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIlluminating the mechanisms controlling glucose homeostasis may deepen our understanding of the pathogenesis of T2DM and provide new therapeutic strategies for T2DM in future. As reported, Dyrk1b […]
- GSE290921 CD4+ tissue resident memory Th17 cells drive IL-17A-mediated joint pathology in Spondyloarthritis May 29, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInterleukin (IL)-17A plays a central role in driving joint pathology in Spondyloarthritis (SpA). In this study, synovial tissues from patients with Axial SpA and Psoriatic arthritis were analyzed using single-cell RNA sequencing and spatial RNA profiling to pinpoint the ce […]
- GSE268703 Human post-mortem skin samples from slow death and fast death May 29, 2025Contributors : Ahmed S Abouhashem ; Kanhaiya Singh ; Chandan K SenSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensHuman death marks the end of organismal life under conditions such that the components of the human body continue to be alive. Such postmortem cellular survival depends on the nature (Hardy scale) of human death. […]
- GSE292938 Targeting the CD40 Co-stimulatory receptor to improve virotherapy efficacy in diffuse midline gliomas May 29, 2025Contributors : Sara Labiano ; Iker Ausejo-Mauleón ; Virginia Laspidea ; Javier Marco-Sanz ; Reyes Hernández-Osuna ; Marc García Moure ; Daniel de la Nava ; Marisol Gonzalez-Huarriz ; Timothy N Phoenix ; Ibon Tamayo ; Marta Zalacain ; Andrea Lacalle ; Lucía Marrodán ; Montserrat Puigdelloses ; Irati Hervás-Corpión ; Maria C Ochoa ; Noelia Casares ; Oren B Bec […]
- GSE291451 Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity May 29, 2025Contributors : Singh Shilpa ; Oser MatthewSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer cell proliferation requires precise control of E2F1 activity; excess activity promotes apoptosis. We developed cell-permeable and bioavailable macrocycles that selectively kill small cell lung cancer (SCLC) cells with inhere […]
- GSE298092 The genomic instability mechanism of histone oncogenic mutation H2BE112K in Schizosaccharomyces pombe genetic analysis May 29, 2025Contributor : Gang FengSeries Type : Expression profiling by high throughput sequencingOrganism : Schizosaccharomyces pombeTo investigate the different of gene expression between E112K、E112K clr6-1 and wild strain, and then, we performed the gene expression analysis from the RNA-Seq data.
- GSE298096 ISG15-Mediated Suppression of Type I Interferon Signaling Leads to Susceptibility to Epstein-Barr Virus Infection (Early_Infection_day7_BulkRNAseq) May 29, 2025Contributors : Nicolas M Reinoso-Vizcaino ; Micah A LuftigSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpstein-Barr Virus (EBV), the first identified human oncogenic virus, is linked to numerous malignancies, including gastric cancer, nasopharyngeal cancer and multiple B-cell Lymphomas. However, the host-virus intera […]
- GSE298155 Splenic accumulation of PD-1+ TIGIT+ CD4+ T cells and elevated of IL1R2 expression suppress antibody production during aging May 29, 2025Contributors : Fang Wu ; Ming Zhang ; Bing FangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging populations and infectious diseases are posing increasingly significant global challenges. The the immune system’s changes, particularly in the spleen, are crucial for elderly individuals to combat infections. However, t […]
- GSE274783 The role of the DRW1 overexpression on the gene expression levels and RNA m5C levels in rice grains. May 29, 2025Contributors : Liwen Yang ; Xiaofeng GuSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Oryza sativaDRW1 controls gene expression contributed to hormone pathway, photosynthesis, carbon metabolism as well as cell division and proliferation .DRW1 controls RNA m5C levels of transcripts contributed to hormone pathway, photosynth […]
- GSE290517 Epigenetic priming of embryonic enhancer elements coordinates developmental gene networks [CUT&TAG] May 29, 2025Contributors : Christopher D Todd ; Jannat Ijaz ; Fereshteh Torabi ; Oleksandr Dovgusha ; Stephen Bevan ; Olivia Cracknell ; Tim Lohoff ; Stephen Clark ; Ricard Argelaguet ; Juliette Pearce ; Ioannis Kafetzopoulos ; Alice Santambrogio ; Jennifer Nichols ; Ferdinand von Meyenn ; Ufuk Guenesdogan ; Stefan Schoenfelder ; Wolf ReikSeries Type : Genome binding/oc […]