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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE233822 Transcriptional profiles of mouse retinal ganglion cells after optic nerve crush [RGC_injury_2019-9205_He] May 16, 2025Contributors : Aboozar Monavarfeshani ; Feng Tian ; Songlin Zhou ; Zhigang HeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe removal of the Structure Specific Recognition Protein 1 (Ssrp1) gene from retinal ganglion cells has been shown to improve their survival after acute optic nerve injury in mice. To investigate […]
- GSE267434 Investigation of common genes and regulatory mechanisms of hyperlipidemia and aortic dissection May 16, 2025Contributors : Meng Wang ; Qingliang Chen ; Chao ChangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to elucidate the common genes and regulatory mechanisms underlying hyperlipidemia and aortic dissection.
- GSE233824 Sciatic nerve crush regulation of RNA alternative poly-adenylation [DRGinjury_2019-QuantSeq_Rev_24h] May 16, 2025Contributors : Michael Fainzilber ; Indrek KoppelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPoly-adenylation regulates post-transcriptional processing and localization of mRNA. To study the effect of nerve injury on poly-adenylation across the transcriptome, 3'-end RNAseq was carried on DRG neurons following s […]
- GSE273989 Recurrent FGFR-alterations are frequent oncogenic drivers and therapeutic targets in pediatric low-grade gliomas [RNA-seq] May 16, 2025Contributors : April Apfelbaum ; Pratiti BandopadhayaySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlterations in Fibroblast growth factor receptor proteins frequently occur as oncogenes in many cancers. FGFR alterations have been reported in a subset of pediatric gliomas, representing a therapeutic target for precis […]
- GSE267704 Single cell gene expression profile of corneal endothelial cells from 2-month-old and 11-month-old murine cornea May 16, 2025Contributors : Raneesh Ramarapu ; Sangwan Park ; Brian C Leonard ; Nayeli Echeverria ; Vijaykrishna Raghunathan ; Panteleimon Rompolas ; Sara M ThomasySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCorneal endothelial cells are highly metabolically active and generally non-proliferative cells required for their corneal […]
- GSE230719 AP-1 inhibition in DRG neurons by A-Fos dominant negative construct May 16, 2025Contributors : Michael Fainzilber ; Eitan ZahaviSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrior analysis suggsted that that AP-1 TFs play a role in expression of specific B2-SINE following in-vivo nerve injury. We thus sought to experimnetally test the role of AP-1 transcription factors in upregulation of B2-SINE […]
- GSE203635 Transcriptomics provides novel insights into the regulatory mechanism of Panax notoginseng exosome-like nanoparticles in HSF May 16, 2025Contributor : Zhaowei TengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn current study, we observed that Panax notoginseng exosome-like nanoparticles successfully inhibited apoptosis and promoted proliferation in HSF. Moreover, transcriptomics was implemented to uncover its underlying mechanism. A total of 7924 diff […]
- GSE296469 Inhibition of TGF-beta signalling during zebrafish larval tail regeneration. May 16, 2025Contributor : Henry H RoehlSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThis study investigates the role of TGF-beta signalling during tail regeneration in 72-96 hour old zebrafish. The inhibitor SB431542 was used to inhibit TGF-beta signalling with and without larval tail excision. Control larvae were treated with DM […]
- GSE296459 Transcriptional regulation of albumen biosynthesis in the magnum of broiler breeder hens May 16, 2025Contributors : Prem L Mahato ; Vedbar Khadka ; Ken Macklin ; Rajesh Jha ; Birendra MishraSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusBroiler chicken production is crucial to meet the increasing global food demand. Hyperphagic and obese broiler breeder hens have a short production cycle, which is challenged by age-a […]
- GSE296707 Neuromuscular junction transcriptome analysis of spinal and bulbar muscular atrophy mice implicates sarcomere gene expression and calcium flux dysregulation in disease pathogenesis May 16, 2025Contributors : Anastasia Gromova ; Albert R La SpadaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusX-linked Spinal and Bulbar Muscular Atrophy (SBMA) is a rare, late-onset neuromuscular disease caused by a CAG repeat expansion mutation in the androgen receptor (AR) gene. SBMA is characterized by progressive muscle atro […]
- GSE296512 Effect of DRP1 mutations on synaptic development during iPSC-derived cortical neuron maturation May 16, 2025Contributors : Baum Tierney ; Gama VivianSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWith the advent of exome sequencing, a growing number of children are being identified with de novo loss of function mutations in the large GTPase essential for mitochondrial fission - Dynamin Related Protein 1 (DRP1); these mutatio […]
- GSE296807 Age-associated dysregulation of post-synaptic mitochondria perturbs re-innervation kinetics May 16, 2025Contributors : Steve D Guzman ; Paula M Fraczek ; Klimentini itsani ; Esraa K Furati ; Grace Kenney ; Joe V Chakkalakal ; Carlos A AguilarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAge-associated degeneration of neuromuscular junctions (NMJs) contributes to sarcopenia and motor decline, yet the mechanisms linking m […]
- GSE296943 Deciphering HAND Pathogenesis Using Single-Nucleotide Omics Approaches May 16, 2025Contributors : Michael Bukrinsky ; Dmitri Sviridov ; Tatiana Pushkarsky ; Anelia Horvath ; Siera MartinezSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAlthough antiretroviral therapy (ART) effectively suppresses HIV-1 replication to undetectable levels […]
- GSE297254 Multiplexed Self-Adaptable Janus Hydrogels Rescue Epithelial Malfunction to Shine Complete Trachea Repair May 16, 2025Contributors : Yi Chen ; Hai Tang ; Yan Zhang ; Lei Wang ; Jun Zhu ; Lele Wang ; Anqi Li ; Xiang Zeng ; Binyu Yin ; Yu Liang ; Xiulin Dong ; Ziyin Pan ; Qingfeng Bai ; Long Wang ; Lei Zhang ; Minglei Yang ; Yunlang She ; Weiyan Sun ; Kun Zhang ; Chang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate th […]
- GSE231596 GI-SINE Analyses May 16, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.